User:Elizabeth Cook/Sandbox 1

From Proteopedia

Cat Eye Syndrome Chromosome Region Candidate 2

spinqualitylabelsall models PDB ID: 5V84. CECR2 in complex with Cpd6 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Jmol [1] Contents 1 Function 2 Domain Organization 3 Sequential and Structural Conservation 4 Bromodomains 5 CECR2 Bromodomain 6 Disease and Therapeutics Function Domain Organization Sequential and Structural Conservation Bromodomains CECR2 Bromodomain Disease and Therapeutics These contacts in CECR2. [2]

References

1. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
2. ↑ Crawford TD, Audia JE, Bellon S, Burdick DJ, Bommi-Reddy A, Cote A, Cummings RT, Duplessis M, Flynn EM, Hewitt M, Huang HR, Jayaram H, Jiang Y, Joshi S, Kiefer JR, Murray J, Nasveschuk CG, Neiss A, Pardo E, Romero FA, Sandy P, Sims RJ 3rd, Tang Y, Taylor AM, Tsui V, Wang J, Wang S, Wang Y, Xu Z, Zawadzke L, Zhu X, Albrecht BK, Magnuson SR, Cochran AG. GNE-886: A Potent and Selective Inhibitor of the Cat Eye Syndrome Chromosome Region Candidate 2 Bromodomain (CECR2). ACS Med Chem Lett. 2017 Jun 1;8(7):737-741. doi: 10.1021/acsmedchemlett.7b00132. , eCollection 2017 Jul 13. PMID:28740608 doi:http://dx.doi.org/10.1021/acsmedchemlett.7b00132