Main Page

by Eric Martz
Black spots are mutations of concern in SARS-CoV-2 spike protein reported by UK scientists in December, 2020. RNA viruses mutate quickly so mutations are expected. These mutations may speed up contagion, but are unlikely to cause more severe COVID-19 and unlikely to reduce vaccine effectiveness. ACE2 binding residues. Animation shows priming via cleavage by furin.
>>> Visit this page >>>

G Atilla-Gocumen, L Di Costanzo, E Meggers. J Biol Inorg Chem. 2010 doi: 10.1007/s00775-010-0699-x
A crystal structure of an organometallic half-sandwich ruthenium complex bound to glycogen synthase kinase 3ß (GSK-3ß) reveals that the inhibitor binds to the ATP binding site via an induced fit mechanism utilizing several hydrogen bonds and hydrophobic interactions. Importantly, the metal is not involved in any direct interaction with the protein kinase but fulfills a purely structural role.

>>> Visit this I3DC complement >>>

J Prilusky, E Hodis doi: 10.14576/431679.1869588
This tutorial is designed for high school and beginning college students. When we breathe oxygen from the air is taken up by blood in our lungs and soon delivered to each of the cells in our body through our circulatory system. Among other uses, our cells use oxygen as the final electron acceptor in a process called aerobic respiration – a process that converts the energy in food and nutrients into a form of energy that the cell can readily use (molecules of ATP, adenosine triphosphate).

>>> Visit this tutorial >>>