2vab
From Proteopedia
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MHC CLASS I H-2KB HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND SENDAI VIRUS NUCLEOPROTEIN
Overview
The x-ray structures of a murine MHC class I molecule (H-2Kb) were, determined in complex with two different viral peptides, derived from the, vesicular stomatitis virus nucleoprotein (52-59), VSV-8, and the Sendai, virus nucleoprotein (324-332), SEV-9. The H-2Kb complexes were refined at, 2.3 A for VSV-8 and 2.5 A for SEV-9. The structure of H-2Kb exhibits a, high degree of similarity with human HLA class I, although the individual, domains can have slightly altered dispositions. Both peptides bind in, extended conformations with most of their surfaces buried in the H-2Kb, binding groove. The nonamer peptide maintains the same amino- and, carboxyl-terminal interactions as the octamer primarily by the insertion, of a bulge in the center of an otherwise beta conformation. Most of the, specific interactions are between side-chain atoms of H-2Kb and main-chain, atoms of peptide. This binding scheme accounts in large part for the, enormous diversity of peptide sequences that bind with high affinity to, class I molecules. Small but significant conformational changes in H-2Kb, are associated with peptide binding, and these synergistic movements may, be an integral part of the T cell receptor recognition process.
About this Structure
2VAB is a Protein complex structure of sequences from Mus musculus and Sendai virus. This structure superseeds the now removed PDB entry 1VAB. The following page contains interesting information on the relation of 2VAB with [Major Histocompatibility Complex]. Full crystallographic information is available from OCA.
Reference
Crystal structures of two viral peptides in complex with murine MHC class I H-2Kb., Fremont DH, Matsumura M, Stura EA, Peterson PA, Wilson IA, Science. 1992 Aug 14;257(5072):919-27. PMID:1323877
Page seeded by OCA on Sun Nov 18 09:09:49 2007
