User:Wayne Chang
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Assignment 12: IVC: Ammonium Binding Site
Mapping the Ammonium binding site and explaining how it contributes to catalysis.
Chang, Wayne and Kaushal, Pankaj.
University of Maryland, Baltimore County (UMBC).
Script Exercises
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Outline
Glutamine synthetase catalyzes the condensation of glutamate and ammonia, using ATP, to form glutamine, ADP, and an inorganic phosphate group.
Glutamate + ATP + NH3 → Glutamine + ADP + phosphate
References
1. Liaw, S-H, et.al.,Discovery of the ammonium substrate site on glutamine synthetase, a third cation binding site Protein Sci. 1995 4: 2358-2365[1]
