User:Karl E. Zahn/Sandbox RB69 1/palm-domain

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The two-metal ion mechanism employed during the DNA pol catalytic cycle relies on coordination of divalent cations by conserved motifs in the palm domain[1][2]. The palm domain of RB69 DNA pol (residues 383-468, 573-729) contains such (DTD) that are particularly conserved in family B DNA pols. Interestingly, the residue T622 in this sequence must obtain a high energy conformation in order to correctly orient the Asp residues. This property is evident in Ramachandran plots of RB69 DNA pol where T622 is an obvious out-layer.

Palm and Active Site of RB69 polymerase: 2ozs

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Karl E. Zahn

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