Induced fit

From Proteopedia

Morph of hexokinase in the open 3o80 and glucose-bound closed 3o8m conformation. For reference, glucose (purple) is shown throughout the morph. Two views are shown, an overview as spacefill and a detail of the binding site in wireframe.

Induced fit describes a conformational change in a protein when it binds a ligand, in contrast to a lock-and-key model of ligand binding. A classic example of induced fit is binding of glucose to hexokinase, depicted in a morph between 3o8m and 3o80 in the picture at right.

1 History of the concept
2 Interactive examples
3 See Also
4 References

History of the concept

Induced fit was suggested by Koshland in 1958 ^[1], providing an alternative to the lock-and-key binding model that Emil Fischer proposed in 1899 ^[2].

Interactive examples

This is a morph of the closed and open form of hexokinase (be patient when loading this). The first and the last frame of the animation are models based on crystallographic data while the intermediate states are somewhat arbitrary, but chosen to show a smooth transition between conformations.

Open Closed Animated