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Article title matches
- Category:Gcgr (35 bytes)
1: List of pages with the keyword Gcgr - Category:Anti-gcgr (40 bytes)
1: List of pages with the keyword Anti-gcgr - Category:Human gcgr receptor (50 bytes)
1: List of pages with the keyword Human gcgr receptor
Page text matches
- 4l6r (4,403 bytes)
14: .... Beyond the shared seven transmembrane fold, the GCGR transmembrane domain deviates from class A G-prot... - 4lex (3,090 bytes)
11: ... present a model for the allosteric inhibition of GCGR by a monoclonal antibody that may form the basis ... - 4lf3 (3,676 bytes)
13: ... present a model for the allosteric inhibition of GCGR by a monoclonal antibody that may form the basis ... - Category:Gcgr (35 bytes)
1: List of pages with the keyword Gcgr - Category:Anti-gcgr (40 bytes)
1: List of pages with the keyword Anti-gcgr - 5ee7 (5,666 bytes)
2: ...Crystal structure of the human glucagon receptor (GCGR) in complex with the antagonist MK-0893==
14: ...r MK-0893, which is structurally similar to other GCGR antagonists, suggests that glucagon activation of... - Sandbox Reserved 1165 (16,340 bytes)
5: ...od_sugar_regulation glucose homeostasis]. Class B GCGRs are composed of a [https://en.wikipedia.org/wiki...
9: ...536/Final_helix_1/2'>helix one</scene> in class B GCGR, located in the 7TM, is longer than any known cla...
21: ...he open conformation is when glucagon can bind to GCGR; in the closed conformation binding does not occu...
24: .../ref> This image depicts the open conformation of GCGR.]]
29: ...gon'''The primary sequence of glucagon, ligand to GCGR, is 29 amino acids.]] - Sandbox Reserved 1166 (3,031 bytes)
30: ...scene> which serves to stabilize the structure of GCGR. - Sandbox Reserved 1167 (10,291 bytes)
6: The '''human glucagon receptor''' ('''GCGR''') is one of 15 secretin-like, or Class B, [http...
11: ...into the blood stream. Overall, activation of the GCGR elevates blood sugar levels.
18: ...opic_glutamate_receptor metabotropic glutamate]), GCGR has a 7tm domain. While class B receptors do shar...
28: === GCGR-Specific Traits ===
34: The GCGR also contains an intracellular Helix VIII that is... - Sandbox Reserved 1180 (11,530 bytes)
10: ==Glucagon Receptor (GCGR)==
11: ...ref name= "Ahren 2009">DOI 10.1038/nrd2782</ref> GCGR can regulate additional signal pathways, includin...
13: ... of adipose tissue in the organism. Activation of GCGR by glucagon initiates triacylglycerol breakdown a...
17: ...u 2013"/> Structural integrity of this domain in GCGR is <scene name='72/721552/The_right_one/3'>essent...
19: ...changes that transduce cell signals endogenously. GCGR is known to regulate additional signal pathways t... - Sandbox Reserved 1181 (2,592 bytes)
21: ...75 px|left|thumb|Fig. 14: Distance measurement of GCGR 7TMD Y138-D362 of 19-20 angstroms and labeled wit...
22: ...of 22-24 angstroms and labeled with complimentary GCGR 7TMD residue interactions.]] - User:Dean Williams/Sandbox 1180 (14,329 bytes)
6: The glucagon class B GPCR (GCGR) is involved in glucose homeostasis through the b...
13: ...en 2009">DOI 10.1038/nrd2782</ref> Additionally, GCGR can regulate additional signal pathways including...
19: ...membrane. Structural integrity of this domain in GCGR is essential to ligand binding affinity. (Fig's 1...
51: ...s, and is the focus of much current research into GCGR signal regulation. <ref name= "Hollenstein 2014"/...
76: ===Structurally Significant GCGR 7TDM Residues=== - User:R. Jeremy Johnson/Glucagon Receptor (22,605 bytes)
5: ... |250 px|left|thumb|'''Figure 1''': Snake Plot of GCGR TMD. Residues of particular importance in glucago...
10: ...536/Final_helix_1/2'>helix one</scene> in class B GCGR is longer than any known class A GPCR structure a...
14: ...he open conformation is when glucagon can bind to GCGR; in the closed conformation binding does not occu...
16: ==Glucagon Receptor (GCGR)==
17: ...ref name= "Ahren 2009">DOI 10.1038/nrd2782</ref> GCGR can regulate additional signal pathways, includin... - Glucagon receptor (23,797 bytes)
10: ... |250 px|left|thumb|'''Figure 1''': Snake Plot of GCGR TMD. Residues of particular importance in glucago...
15: ...536/Final_helix_1/2'>helix one</scene> in class B GCGR is longer than any known class A GPCR structure a...
19: ...he open conformation is when glucagon can bind to GCGR; in the closed conformation binding does not occu...
21: ==Glucagon Receptor (GCGR)==
22: ...ref name= "Ahren 2009">DOI 10.1038/nrd2782</ref> GCGR can regulate additional signal pathways, includin... - 8jit (6,531 bytes)
2: ...the GLP-1R/GCGR dual agonist MEDI0382-bound human GCGR-Gs complex==
16: ...-TM2 cleft, in line with its increased potency at GCGR than SAR425899. Together, the results provide ins...
18: ...ctural analysis of the dual agonism at GLP-1R and GCGR.,Li Y, Zhou Q, Dai A, Zhao F, Chang R, Ying T, Wu... - 8jiu (4,279 bytes)
2: ...he GLP-1R/GCGR dual agonist SAR425899-bound human GCGR-Gs complex== - 8jip (4,748 bytes)
2: ==Cryo-EM structure of the GLP-1R/GCGR dual agonist MEDI0382-bound human GLP-1R-Gs compl...
14: ...-TM2 cleft, in line with its increased potency at GCGR than SAR425899. Together, the results provide ins...
16: ...ctural analysis of the dual agonism at GLP-1R and GCGR.,Li Y, Zhou Q, Dai A, Zhao F, Chang R, Ying T, Wu... - 8jiq (4,042 bytes)
2: ...e GLP-1R/GCGR dual agonist Peptide 15-bound human GCGR-Gs complex== - 8jir (4,876 bytes)
2: ==Cryo-EM structure of the GLP-1R/GCGR dual agonist SAR425899-bound human GLP-1R-Gs comp...
14: ...-TM2 cleft, in line with its increased potency at GCGR than SAR425899. Together, the results provide ins...
16: ...ctural analysis of the dual agonism at GLP-1R and GCGR.,Li Y, Zhou Q, Dai A, Zhao F, Chang R, Ying T, Wu... - 8jis (4,689 bytes)
2: ==Cryo-EM structure of the GLP-1R/GCGR dual agonist peptide15-bound human GLP-1R-Gs comp...
13: ...-TM2 cleft, in line with its increased potency at GCGR than SAR425899. Together, the results provide ins...
15: ...ctural analysis of the dual agonism at GLP-1R and GCGR.,Li Y, Zhou Q, Dai A, Zhao F, Chang R, Ying T, Wu...
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