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- Image:LCB1 RBD.png (0 bytes)
- Image:LCB1.pdb (0 bytes)
- Image:LCB1 Methodology.png (0 bytes)
- Image:LCB1 new side 1.png (0 bytes)
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- Engineered Protein Inhibitors of SARS-CoV-2 Entry (10,254 bytes)
19: ...e use of the De Novo protein design to create the LCB1 and LCB3 inhibitors (7JZL).]]
23: ...s how the <scene name='10/1078124/Lcb1_general/2'>LCB1</scene> and <scene name='10/1078124/Lcb3_general/...
26: ...78124/Lcb1_internal_stability/1'>nonpolar core of LCB1</scene> and <scene name='10/1078124/Lcb3_internal...
35: ...e 4: The sequence differences between ACE2, AHB2, LCB1 and LCB3.]]
36: ...on LCB1 and LCB3. <scene name='10/1078124/Lcb1/1'>LCB1 binding</scene> reveals hydrogen bonding between ... - New Test (8,065 bytes)
23: ...e use of the De Novo protein design to create the LCB1 and LCB3 inhibitors.]]
25: ...n as the de novo protein design and it is how the LCB1 and LCB3 mini-binders were created. Figure 3 show...
32: ...78118/Lcb1_internal_stability/1'>Nonpolar core of LCB1</scene>
42: ...on LCB1 and LCB3. <scene name='10/1075219/Lcb1/4'>LCB1 binding</scene> reveals hydrogen bonding between ...
48: ...e 4: The sequence differences between ACE2, AHB2, LCB1 and LCB3.]] - Image:D30lcb.png (42 bytes)
1: D30 residue of LCB1 on Covid spike protein - Image:D30image.png (28 bytes)
1: D30 of LCB1 on spike protein - Engineered Protein Inhibitors for SARS-CoV-2 Entry (8,053 bytes)
23: ...e use of the De Novo protein design to create the LCB1 and LCB3 inhibitors.]]
25: ...n as the de novo protein design and it is how the LCB1 and LCB3 mini-binders were created. Figure 3 show...
32: ...78118/Lcb1_internal_stability/1'>Nonpolar core of LCB1</scene>
42: ...on LCB1 and LCB3. <scene name='10/1075219/Lcb1/4'>LCB1 binding</scene> reveals hydrogen bonding between ...
48: ...e 4: The sequence differences between ACE2, AHB2, LCB1 and LCB3.]] - User:Matthew Pereira/Sandbox Experimental (5,791 bytes)
1: ...n='SARS-CoV-2 Spike Protein Bound to Minibinders (PDB 7jzl)' scene='10/1075220/Monomerwithminibinder/4'...
23: ...e use of the De Novo protein design to create the LCB1 and LCB3 inhibitors.]]
25: ...n as the de novo protein design and it is how the LCB1 and LCB3 mini-binders were created.
29: ...77473/Lcb1_internal_stability/1'>Nonpolar core of LCB1</scene>,
37: <scene name='10/1075219/Lcb1/1'>LCB1 binding site</scene> - User:Elizabeth Yowell/ SandboxFinal (5,599 bytes)
3: ...n='SARS-CoV-2 Spike Protein Bound to Minibinders (PDB 7jzl)' scene='10/1075220/Monomerwithminibinder/4'...
35: ...e use of the De Novo protein design to create the LCB1 and LCB3 inhibitors.]]
37: ...n as the de novo protein design and it is how the LCB1 and LCB3 mini-binders were created.
51: <scene name='10/1075219/Lcb1/1'>LCB1 binding site</scene>
61: ...humb|The sequence differences between ACE2, AHB2, LCB1and LCB3.]] - Image:Spikeblockedbyminibinder.pdb (65 bytes)
1: ACE-2 receptor bound to spike RBD overlayed with LCB1 minibinder. - Image:LCB1minibinder.pdb (17 bytes)
1: LCB1 in isolation - User:Elizabeth Yowell/SandboxGiavanna (2,341 bytes)
1: ...d</scene>=SARS CoV-2 Protein Inhibitors (AHB2 and LCB1/LCB3)=
38: ===PDB Files=== - User:Rachael Vavul/Sandbox 1 (3,448 bytes)
26: ...='right' caption='LCB1-Spike Protein Interaction (PDB entry [[7JZL]])' scene='7'>
31: === LCB1 ===
34: <scene name='10/1076042/Overall_lcb1_spike/3'>LCB1-Single Spike Chain Interaction</scene>
36: <scene name='10/1076042/Correct_colors_lcb1_spike_res/1'>TextToBeDisplayed</scene>
39: LCB1 is a spike protein competitive inhibitor. It was ... - User:Carson Powers/Sandbox 1 (9,198 bytes)
2: ...ace. PDB file: 7jzl' scene='10/1076041/Spike_with_lcb1/3'>
23: ... have been optimized. Its <scene name='10/1076041/Lcb1_interactions/5'>binding interactions</scene> show...
25: ...o show a large number of hydrogen bonds. However, LCB1 has more surface area and fits more precisely wit...
28: ...y than the ACE2 receptor. The final structures of LCB1 and LCB3 differed by around had very low deviatio...
31: ...rotein structure. But overall, the development of LCB1 and LCB3 validates the reliability, efficiency, a... - User:Lucas Davis/Sandbox 1 (1,421 bytes)
1: =LCB1 Minibinder Test Page=
2: ...ike protein (PDB: 7JZU)' scene=’10/1076039/Only_lcb1/1’>
8: <scene name='10/1076039/Only_lcb1/1'>LCB1</scene> - User:Mark Macbeth/SandboxGiavanna (987 bytes)
1: =SARS CoV-2 Protein Inhibitors (AHB2 and LCB1/LCB3)=
27: ===PDB Files=== - User:Shea Bailey/Sandbox 1 (7,861 bytes)
23: ...e use of the De Novo protein design to create the LCB1 and LCB3 inhibitors (7JZL).]]
25: ...n as the de novo protein design and it is how the LCB1 and LCB3 mini-binders were created. Figure 3 show...
28: ...78124/Lcb1_internal_stability/1'>nonpolar core of LCB1</scene> and <scene name='10/1078124/Lcb3_internal...
36: ...on LCB1 and LCB3. <scene name='10/1075219/Lcb1/4'>LCB1 binding</scene> reveals hydrogen bonding between ...
42: ...e 4: The sequence differences between ACE2, AHB2, LCB1 and LCB3.]] - User:Matthew Pereira/Sandbox 1 (8,019 bytes)
22: ...e use of the De Novo protein design to create the LCB1 and LCB3 inhibitors (7JZL).]]
24: ...n as the de novo protein design and it is how the LCB1 and LCB3 mini-binders were created. Figure 3 show...
27: ...78124/Lcb1_internal_stability/1'>nonpolar core of LCB1</scene> and <scene name='10/1078124/Lcb3_internal...
35: ...on LCB1 and LCB3. <scene name='10/1075219/Lcb1/4'>LCB1 binding</scene> reveals hydrogen bonding between ...
41: ...e 4: The sequence differences between ACE2, AHB2, LCB1 and LCB3.]] - 8c81 (3,777 bytes)
7: ...lpha-D-glucopyranoside'>Q7G</scene>, <scene name='pdbligand=Z8A:N-[(2S,3S,4R)-1,3,4-trihydroxyoctadecan...
8: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8c81 ProSAT]</span></td></tr>
11: ... Acts by inhibiting serine palmitoyltransferases (LCB1 and LCB2) activity.<ref>PMID:20182505</ref>
20: <div class="pdbe-citations 8c81" style="background-color:#fffaf0;... - 7jzl (4,825 bytes)
2: ==SARS-CoV-2 spike in complex with LCB1 (2RBDs open)==
7: ...<td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td...
8: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jzl ProSAT]</span></td></tr>
20: <div class="pdbe-citations 7jzl" style="background-color:#fffaf0;... - 7jzu (4,907 bytes)
2: ...omplex with LCB1 (local refinement of the RBD and LCB1)==
7: ...and=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td...
8: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jzu ProSAT]</span></td></tr>
20: <div class="pdbe-citations 7jzu" style="background-color:#fffaf0;... - Sandbox Reserved 1848 (7,801 bytes)
3: ...t' frame='true' caption='LCB1 with spike protein, PDB code:7jzu' scene=''>
10: ... however it ended up having a lower affinity than LCB1 with a higher IC<sub>50</sub> value of 40.1 pM<re...
12: ...ue. However, these interactions are not required. LCB1 forms no interactions with the Gln493 residue of ...
14: ...ion, further contributing to the high affinity of LCB1 to the spike protein.
27: Image of D30 on LCB1 attached to spike
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