Microtubule-associated protein
From Proteopedia
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<StructureSection load='2zjd' size='340' side='right' caption='Human microtubule-associated protein light chain 3B (grey and pink) complex with sequestosome peptide (green and yellow) (PDB code [[2zjd]])' scene=''> | <StructureSection load='2zjd' size='340' side='right' caption='Human microtubule-associated protein light chain 3B (grey and pink) complex with sequestosome peptide (green and yellow) (PDB code [[2zjd]])' scene=''> | ||
| - | '''Microtubule-associated protein light chain 3''' (LC3) is recruited to autophagosomal membranes during autophagy. The human LC3B is cleaved after synthesis to expose a C-terminal glycine which binds via a phospholipid anchor to autophagosomal vescicle membranes during autophagy. Thus detection of LC3 is a reliable method for monitoring autophagy. | + | '''Microtubule-associated protein light chain 3''' (LC3) is recruited to autophagosomal membranes during autophagy. The human LC3B is cleaved after synthesis to expose a C-terminal glycine which binds via a phospholipid anchor to autophagosomal vescicle membranes during autophagy. Thus detection of LC3 is a reliable method for monitoring autophagy. The microtubule-associated proteins are classsified as 2 types. Type 1 includes MAP1 and type 2 includes MAP2, MAP4 and tau protein [[Tau protein]]. |
== Function == | == Function == | ||
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== Disease == | == Disease == | ||
| - | '''Microtubule-associated protein Tau''' is associated with Alzheimer Disease. Tau forms abnormal aggregates in patients' tissues. | + | '''Microtubule-associated protein Tau''' is associated with Alzheimer Disease. Tau forms abnormal aggregates in patients' tissues. |
== Relevance == | == Relevance == | ||
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**[[2mz7]] – hTau residues 584-629 - NMR<br /> | **[[2mz7]] – hTau residues 584-629 - NMR<br /> | ||
| + | **[[1i8h]] – hTau peptide + PIN1 WW domain - NMR<br /> | ||
| + | **[[2on9]], [[4e0n]], [[4e0o]], [[4e0m]], [[4np8]] – hTau peptide <br /> | ||
| + | **[[3ovl]] – hTau peptide + Orange G<br /> | ||
| + | **[[4glr]], [[4tqe]], [[5dmg]] – hTau peptide + antibody<br /> | ||
| + | **[[4fl5]], [[4y32]], [[4y3b]], [[4y5i]] – hTau peptide + 14-3-3 protein sigma<br /> | ||
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 09:28, 22 February 2016
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3D Structures of microtubule-associated protein
Updated on 22-February-2016
References
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky
