Microtubule-associated protein
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
<StructureSection load='2zjd' size='340' side='right' caption='Human microtubule-associated protein light chain 3B (grey and pink) complex with sequestosome peptide (green and yellow) (PDB code [[2zjd]])' scene=''> | <StructureSection load='2zjd' size='340' side='right' caption='Human microtubule-associated protein light chain 3B (grey and pink) complex with sequestosome peptide (green and yellow) (PDB code [[2zjd]])' scene=''> | ||
| - | '''Microtubule-associated protein light chain 3''' (LC3) is recruited to autophagosomal membranes during autophagy. The human LC3B is cleaved after synthesis to expose a C-terminal glycine which binds via a phospholipid anchor to autophagosomal vescicle membranes during autophagy. Thus detection of LC3 is a reliable method for monitoring autophagy. The microtubule-associated proteins are classsified as 2 types. Type 1 includes MAP1 and type 2 includes MAP2, MAP4 and | + | '''Microtubule-associated protein light chain 3''' (LC3) is recruited to autophagosomal membranes during autophagy. The human LC3B is cleaved after synthesis to expose a C-terminal glycine which binds via a phospholipid anchor to autophagosomal vescicle membranes during autophagy. Thus detection of LC3 is a reliable method for monitoring autophagy. The microtubule-associated proteins are classsified as 2 types. Type 1 includes MAP1 and type 2 includes MAP2, MAP4 and [[Tau protein]]. |
== Function == | == Function == | ||
| Line 46: | Line 46: | ||
**[[3ovl]] – hTau peptide + Orange G<br /> | **[[3ovl]] – hTau peptide + Orange G<br /> | ||
**[[4glr]], [[4tqe]], [[5dmg]] – hTau peptide + antibody<br /> | **[[4glr]], [[4tqe]], [[5dmg]] – hTau peptide + antibody<br /> | ||
| - | **[[4fl5]], [[4y32]], [[4y3b]], [[4y5i]] – hTau peptide + 14-3-3 protein | + | **[[4fl5]], [[4y32]], [[4y3b]], [[4y5i]] – hTau peptide + 14-3-3 protein σ<br /> |
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 09:30, 22 February 2016
| |||||||||||
3D Structures of microtubule-associated protein
Updated on 22-February-2016
References
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky
