Main Page 20190127

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<applet load="1eve" size="400" color="white" frame="true" align="right" spinBox="true" script="1eve/E2020_in_ache/6" caption="PDB: 1eve, resolution 2.50&Aring;. DRAG TO ROTATE." />
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<span style="font-size:2.0em; border:none; margin:0; padding:0.3em; color:#000;">Welcome to Proteopedia</span>
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<span style="top:+0.2em; font-size:1.2em; padding-left:5px;">The free, collaborative 3D-encyclopedia of proteins & other molecules</span>
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<span style="top:+0.2em; font-size:1.2em; padding-right:5px;">'''''ISSN 2310-6301'''''</span>
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<span style="font-size:1.5em; border:none; margin:0; padding:0.3em;font-weight:bold;"> [[Proteopedia:Table of Contents|Table of Contents]] * [[Proteopedia:Structure Index|Structure Index]] * [[Krebs_cycle_overview|Function to Structure]] * [[Proteopedia:About|About]] * [[Proteopedia:Video_Guide|Video Guide]] * [[Help:Contents|Help]]</span>
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<big>Welcome to Proteopedia,</big>
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The collaborative, 3D encyclopedia of proteins and other molecules.
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<big>''Here's an excerpt from one of our pages:''</big>
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The anti-Alzheimer's drug E2020 (marketed as Aricept&reg;) is an inhibitor that binds acetylcholinesterase (AChE) with high affinity. The X-ray structure of the E2020-AChE (AChE from ''Torpedo california'') complex shows that E2020 has a '''<scene name='1eve/E2020_close_up_with_84_279/7'>unique orientation</scene>''' along the active-site gorge, extending from the anionic subsite (<scene name='1eve/E2020_close_up_with_84lbld/3'>W84</scene>) of the active site, at the bottom, to the peripheral anionic site (<scene name='1eve/E2020_close_up_with_84_279lbld/2'>near W279</scene>), at the top, via aromatic stacking interactions with conserved aromatic acid residues. E2020 does not, however, interact directly with either the catalytic triad or the 'oxyanion hole' but only <scene name='1eve/E20_interactionshown/3'>indirectly via solvent molecules</scene>.
 
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===See more!===
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====Favorites====
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Here are several of our favorite pages. Visit them to get a feeling for Proteopedia:
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* [[Hemoglobin]]
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* [[1eve | Acetylcholinesterase with the anti-Alzheimer's drug Aricept bound]]
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* [[1v04 | Serum Paraoxonase-1 created by directed evolution]].
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====Browse!====
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<table border="0"><tr><td>
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* [[Special:Popularpages | Most-popular pages]]
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We encourage you to '''edit pages freely''' (you need a user account to edit at the moment, so ask us for one).
 
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These resources may help you familiarize yourself with the editing process. Trust us, the editing process is very simple: All text is edited the same way that Wikipedia is edited, so it must be easy! And all scenes are created using our user-friendly ''Scene authoring tools''. Of course it helps to familiarize yourself with the site and how to go about editing, so check out these resources:
 
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===Proteopedia Mission Statement===
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To collect and disseminate structural biological and biological knowledge about proteins, RNA, DNA, and their assemblies and interacting small molecules in a manner that is relevant and accessible to scientists of all the biological and chemical fields.
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Current revision


Proteopedia Page Contributors and Editors (what is this?)

Eran Hodis, Eric Martz, Joel L. Sussman, Jaime Prilusky, David Canner

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