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Troponin

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{{STRUCTURE_1yv0| PDB=1yv0 | SIZE=400| SCENE=Troponin/Cv/1 |right|CAPTION=Chicken troponin: subunit T (dark green), subunit I (wheat), subunit C (pink) complex with Mg+2 ion (green) [[1yv0]] }}
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<StructureSection load='1yv0' size='350' side='right' caption='Chicken troponin: subunit T (dark green), subunit I (wheat), subunit C (pink) complex with Mg+2 ion (green) [[1yv0]]' scene=''>
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__TOC__
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== Function ==
[[Troponin]] (Tn) is a regulatory protein in muscle contraction. It contains 3 subunits:<br />
[[Troponin]] (Tn) is a regulatory protein in muscle contraction. It contains 3 subunits:<br />
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* '''TnC''' causes conformational change in TnI when it binds to calcium ions. For more details on TnC see [[ Role of Troponin C in decreased muscle sensitivity to calcium]].<br />
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* '''TnC''' causes conformational change in TnI when it binds to calcium ions<ref>PMID:26232335</ref>. For more details on TnC see<br />
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[[ Role of Troponin C in decreased muscle sensitivity to calcium]]<br />
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[[Human Cardiac Troponin C]]<br />
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[[Human Cardiac Troponin C in complex with the Green Tea Polyphenol]]<br />
* '''TnT''' binds to [[Tropomyosin|tropomyosin]].<br />
* '''TnT''' binds to [[Tropomyosin|tropomyosin]].<br />
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* '''TnI''' binds to actin which is found in thin muscle filaments.<br />
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* '''TnI''' binds to actin which is found in thin muscle filaments. See [[Human Cardiac Troponin I]]<br />
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See additional details in [[Human Cardiac Troponin C]].
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== Disease ==
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Mutations in TnI<ref>PMID:9241277</ref> and TnT <ref>PMID:11606294</ref>are associated with hypertrophic cardiomyopathy.
== 3D Structures of Troponin ==
== 3D Structures of Troponin ==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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[[Troponin 3D structures]]
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{{#tree:id=OrganizedByTopic|openlevels=0|
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* Troponin C+Troponin I+Troponin T
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**[[2w49]], [[2w4u]] – cTnC+cTnI+cTnT+tropomyosin+actin – chicken<br />
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**[[1ytz]] - cTnC+cTnI+cTnT+Ca<br />
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**[[1yv0]] - cTnC+cTnI+cTnT<br />
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**[[1j1d]], [[1j1e]] – hTnC (mutant)+hTnI (mutant) fragment+hTnT fragment+Ca - human
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* Troponin C+Troponin I
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**[[2krd]], [[2mkp]] – hTnC+hTnI – NMR<br />
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**[[1ozs]] - hTnC C-terminal+hTnI N-terminal – NMR<br />
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**[[2l1r]] - hTnC C-terminal+hTnI switch region - NMR<br />
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**[[1lxf]], [[1mxl]] - hTnC N-terminal+hTnI fragment<br />
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**[[2kgb]] – hTnC (mutant) regulatory domain+TnI<br />
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**[[1sbj]] – cTnC C-terminal+cTnI N-terminal+Mg++ - NMR<br />
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**[[1scv]], [[1fi5]], [[1blq]] - cTnC C-terminal+cTnI N-terminal – NMR<br />
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**[[1npq]] - cTnC (mutant) N-terminal+cTnI fragment+rhodamine<br />
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**[[1jc2]] - cTnC C-terminal+cTnI N-terminal<br />
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**[[1a2x]] - rTnC +rTnI fragment – rabbit<br />
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**[[3tz1]] - TnC C terminal +TnI fragment – akazara scallop<br />
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* Troponin C
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**[[2kdh]] – hTnC+green tea polyphenol – NMR<br />
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**[[2kfx]] – hTnC (mutant) N-terminal+Ca+naphthalene derivative<br />
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**[[2jt0]], [[2jtz]], [[2jt8]], [[2jt3]] – hTnC (mutant) – NMR<br />
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**[[2jxl]] - hTnC (mutant) N-terminal – NMR<br />
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**[[3rv5]], [[3sd6]], [[3swb]] - hTnC N-terminal<br />
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**[[4gjg]] - hTnC N-terminal (mutant)<br />
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**[[4gjf]] - hTnC N-terminal (mutant) + Cd<br />
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**[[4gje]] - hTnC N-terminal + Cd<br />
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**[[1wrk]], [[1wrl]] - hTnC (mutant) N-terminal+trifluoperazine<br />
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**[[1spy]] - hTnC N-terminal – NMR<br />
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**[[2mle]] - hTnC C-terminal – NMR<br />
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**[[2mlf]] - hTnC C-terminal (mutant) – NMR<br />
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**[[1ih0]] - hTnC C-terminal+EMD 57033 – NMR<br />
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**[[1ap4]] - hTnC N-terminal+Ca – NMR<br />
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**[[2l98]] – hTnC EF-hand domains 3,4 + resveratrol<br />
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**[[1la0]], [[4tnc]] – cTnC+Ca<br />
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**[[1dtl]] – cTnC (mutant)+Ca +bepridil<br />
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**[[1skt]], [[1zac]], [[2ctn]] - cTnC N-terminal – NMR<br />
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**[[1aj4]] - cTnC (mutant) +Ca – NMR<br />
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**[[3ctn]] - cTnC C-terminal – NMR<br />
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**[[1avs]] - cTnC N-terminal+Ca<br />
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**[[1smg]], [[1tnq]] - cTnC N-terminal+Ca - NMR<br />
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**[[1ncy]] – cTnC+Mn<br />
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**[[1ncx]], [[1ncz]], [[1top]] – cTnC<br />
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**[[1pon]], [[1cta]], [[1ctd]] – cTnC fragment – NMR<br />
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**[[1tnp]] - cTnC N-terminal – NMR<br />
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**[[1tnw]], [[1tnx]] - cTnC +Ca - NMR<br />
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**[[1trf]] - tTnC N-terminal+Ca - turkey – NMR<br />
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**[[5tnc]] - tTnC<br />
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**[[2k2a]] - TnC C-terminal – ''Lethocerus indicus'' – NMR<br />
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**[[2jnf]] – TnC – fly – NMR<br />
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**[[1r2u]], [[1r6p]] - TnC N-terminal – trout – NMR<br />
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**[[1tcf]] – rTnC+Ca<br />
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**[[1tn4]], [[2tn4]] – rTnC (mutant)+Ca
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* Troponin I
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**[[2jpw]] – TnI biphosphorylated – mouse – NMR<br />
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**[[1vdi]] – cTnI – NMR<br />
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**[[1vdj]] – cTnI+Ca - NMR
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* Troponin T
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</StructureSection>
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**[[2z5h]] – yTnT fragment+tropomyosin – yeast
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== References ==
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}}
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Chicken troponin: subunit T (dark green), subunit I (wheat), subunit C (pink) complex with Mg+2 ion (green) 1yv0

Drag the structure with the mouse to rotate

References

  1. ↑ Li MX, Hwang PM. Structure and function of cardiac troponin C (TNNC1): Implications for heart failure, cardiomyopathies, and troponin modulating drugs. Gene. 2015 Oct 25;571(2):153-66. doi: 10.1016/j.gene.2015.07.074. Epub 2015 Jul, 29. PMID:26232335 doi:http://dx.doi.org/10.1016/j.gene.2015.07.074
  2. ↑ Kimura A, Harada H, Park JE, Nishi H, Satoh M, Takahashi M, Hiroi S, Sasaoka T, Ohbuchi N, Nakamura T, Koyanagi T, Hwang TH, Choo JA, Chung KS, Hasegawa A, Nagai R, Okazaki O, Nakamura H, Matsuzaki M, Sakamoto T, Toshima H, Koga Y, Imaizumi T, Sasazuki T. Mutations in the cardiac troponin I gene associated with hypertrophic cardiomyopathy. Nat Genet. 1997 Aug;16(4):379-82. PMID:9241277 doi:10.1038/ng0897-379
  3. ↑ Palm T, Graboski S, Hitchcock-DeGregori SE, Greenfield NJ. Disease-causing mutations in cardiac troponin T: identification of a critical tropomyosin-binding region. Biophys J. 2001 Nov;81(5):2827-37. PMID:11606294 doi:http://dx.doi.org/10.1016/S0006-3495(01)75924-3

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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