Troponin
From Proteopedia
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[[Human Cardiac Troponin C in complex with the Green Tea Polyphenol]]<br /> | [[Human Cardiac Troponin C in complex with the Green Tea Polyphenol]]<br /> | ||
* '''TnT''' binds to [[Tropomyosin|tropomyosin]].<br /> | * '''TnT''' binds to [[Tropomyosin|tropomyosin]].<br /> | ||
| - | * '''TnI''' binds to actin which is found in thin muscle filaments.<br /> | + | * '''TnI''' binds to actin which is found in thin muscle filaments. See [[Human Cardiac Troponin I]]<br /> |
== Disease == | == Disease == | ||
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</StructureSection> | </StructureSection> | ||
| - | == 3D Structures of Troponin == | ||
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| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | * Troponin C+Troponin I+Troponin T | ||
| - | |||
| - | **[[1j1d]], [[1j1e]], [[4y99]] – hTnC (mutant)+hTnI (mutant) fragment+hTnT fragment+Ca - human<br /> | ||
| - | **[[6kn8]], [[6kn7]] - hTnC + hTnI + hTnT + actin + tropomyosin – Cryo EM<br /> | ||
| - | **[[7ko4]], [[7ko5]], [[7ko7]], [[7kon]], [[7kor]] - pTnC + pTnI + pTnT + actin + tropomyosin – pig - Cryo EM<br /> | ||
| - | **[[6klu]], [[6klt]] - mTnC + TnI + TnT – mouse - Cryo EM<br /> | ||
| - | **[[2w49]], [[2w4u]] – cTnC+cTnI+cTnT+tropomyosin+actin – chicken<br /> | ||
| - | **[[1ytz]] - cTnC+cTnI+cTnT+Ca<br /> | ||
| - | **[[1yv0]] - cTnC+cTnI+cTnT<br /> | ||
| - | |||
| - | * Troponin C+Troponin I | ||
| - | |||
| - | **[[2krd]], [[2mkp]] – hTnC+hTnI + Ca – NMR<br /> | ||
| - | **[[6mv3]], [[7jgi]] – hTnC/hTnI (mutant) – NMR<br /> | ||
| - | **[[7sc2]], [[7sc3]], [[7sxd]] – hTnC N-domain/hTnI switch region<br /> | ||
| - | **[[5vln]], [[5wcl]], [[5w88]], [[7sxc]] – hTnC N-domain (mutant)/hTnI swich region – NMR<br /> | ||
| - | **[[7kaa]] – hTnC N-domain/hTnI switch region + drug – NMR<br /> | ||
| - | **[[7jgi]], [[7sup]], [[7svc]], [[7swg]], [[7swi]] – hTnC N-domain/hTnI switch region + inhibitor – NMR<br /> | ||
| - | **[[1ozs]] - hTnC C-terminal+hTnI N-terminal – NMR<br /> | ||
| - | **[[2l1r]] - hTnC C-terminal+hTnI switch region - NMR<br /> | ||
| - | **[[1lxf]], [[1mxl]] - hTnC N-terminal+hTnI fragment - NMR<br /> | ||
| - | **[[2n7l]] - hTnC N-terminal/hTnC switch + drug analog – NMR<br /> | ||
| - | **[[2kgb]] – hTnC (mutant) regulatory domain+TnI - NMR<br /> | ||
| - | **[[2mzp]] - hTnC regulatory domain+TnI switch region (mutant) - NMR<br /> | ||
| - | **[[1a2x]] - rTnC +rTnI fragment – rabbit<br /> | ||
| - | **[[1sbj]] – cTnC C-terminal+cTnI N-terminal+Mg - NMR<br /> | ||
| - | **[[1scv]], [[1fi5]], [[1blq]] - cTnC C-terminal+cTnI N-terminal – NMR<br /> | ||
| - | **[[1npq]] - cTnC (mutant) N-terminal+cTnI fragment+rhodamine<br /> | ||
| - | **[[1jc2]] - cTnC C-terminal+cTnI N-terminal<br /> | ||
| - | **[[3tz1]] - TnC C terminal +TnI fragment – akazara scallop<br /> | ||
| - | |||
| - | * Troponin C | ||
| - | |||
| - | **[[2kdh]] – hTnC+green tea polyphenol – NMR<br /> | ||
| - | **[[2jt0]], [[2jtz]], [[2jt8]], [[2jt3]] – hTnC (mutant) – NMR<br /> | ||
| - | **[[3rv5]], [[3sd6]], [[3swb]], [[4gje]], [[1spy]] - hTnC N-terminal<br /> | ||
| - | **[[4gjg]], [[5vln]] - hTnC N-terminal (mutant)<br /> | ||
| - | **[[1ap4]] - hTnC N-terminal+Ca – NMR<br /> | ||
| - | **[[2jxl]], [[2n79]] - hTnC N-terminal (mutant) + Ca – NMR<br /> | ||
| - | **[[4gjf]] - hTnC N-terminal (mutant) + Cd<br /> | ||
| - | **[[1wrk]], [[1wrl]] - hTnC N-terminal (mutant) +trifluoperazine<br /> | ||
| - | **[[5w88]], [[5wcl]] - hTnC N-terminal (mutant) + methyldiphenylamine - NMR<br /> | ||
| - | **[[2kfx]] – hTnC (mutant) N-terminal+Ca+naphthalene derivative<br /> | ||
| - | **[[2mle]] - hTnC C-terminal – NMR<br /> | ||
| - | **[[2mlf]] - hTnC C-terminal (mutant) – NMR<br /> | ||
| - | **[[1ih0]] - hTnC C-terminal+EMD 57033 – NMR<br /> | ||
| - | **[[2l98]] – hTnC EF-hand domains 3,4 + resveratrol<br /> | ||
| - | **[[1tcf]] – rTnC+Ca<br /> | ||
| - | **[[1tn4]], [[2tn4]] – rTnC (mutant)+Ca<br /> | ||
| - | **[[1la0]], [[4tnc]] – cTnC+Ca<br /> | ||
| - | **[[1dtl]] – cTnC (mutant)+Ca +bepridil<br /> | ||
| - | **[[1skt]], [[1zac]], [[2ctn]] - cTnC N-terminal – NMR<br /> | ||
| - | **[[1aj4]] - cTnC (mutant) +Ca – NMR<br /> | ||
| - | **[[3ctn]] - cTnC C-terminal – NMR<br /> | ||
| - | **[[1avs]] - cTnC N-terminal+Ca<br /> | ||
| - | **[[1smg]], [[1tnq]] - cTnC N-terminal+Ca - NMR<br /> | ||
| - | **[[1ncy]] – cTnC+Mn<br /> | ||
| - | **[[1ncx]], [[1ncz]], [[1top]] – cTnC<br /> | ||
| - | **[[1pon]], [[1cta]], [[1ctd]] – cTnC fragment – NMR<br /> | ||
| - | **[[1tnp]] - cTnC N-terminal – NMR<br /> | ||
| - | **[[1tnw]], [[1tnx]] - cTnC +Ca - NMR<br /> | ||
| - | **[[1trf]] - tTnC N-terminal+Ca - turkey – NMR<br /> | ||
| - | **[[5tnc]] - tTnC<br /> | ||
| - | **[[2k2a]] - TnC C-terminal – ''Lethocerus indicus'' – NMR<br /> | ||
| - | **[[2jnf]] – TnC – fly – NMR<br /> | ||
| - | **[[1r2u]], [[1r6p]] - TnC N-terminal – trout – NMR<br /> | ||
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| - | * Troponin I | ||
| - | |||
| - | **[[2jpw]] – mTnI biphosphorylated – NMR<br /> | ||
| - | **[[1vdi]] – cTnI – NMR<br /> | ||
| - | **[[1vdj]] – cTnI+Ca - NMR | ||
| - | |||
| - | * Troponin T | ||
| - | |||
| - | **[[2z5h]] – yTnT fragment+tropomyosin – yeast | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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References
- ↑ Li MX, Hwang PM. Structure and function of cardiac troponin C (TNNC1): Implications for heart failure, cardiomyopathies, and troponin modulating drugs. Gene. 2015 Oct 25;571(2):153-66. doi: 10.1016/j.gene.2015.07.074. Epub 2015 Jul, 29. PMID:26232335 doi:http://dx.doi.org/10.1016/j.gene.2015.07.074
- ↑ Kimura A, Harada H, Park JE, Nishi H, Satoh M, Takahashi M, Hiroi S, Sasaoka T, Ohbuchi N, Nakamura T, Koyanagi T, Hwang TH, Choo JA, Chung KS, Hasegawa A, Nagai R, Okazaki O, Nakamura H, Matsuzaki M, Sakamoto T, Toshima H, Koga Y, Imaizumi T, Sasazuki T. Mutations in the cardiac troponin I gene associated with hypertrophic cardiomyopathy. Nat Genet. 1997 Aug;16(4):379-82. PMID:9241277 doi:10.1038/ng0897-379
- ↑ Palm T, Graboski S, Hitchcock-DeGregori SE, Greenfield NJ. Disease-causing mutations in cardiac troponin T: identification of a critical tropomyosin-binding region. Biophys J. 2001 Nov;81(5):2827-37. PMID:11606294 doi:http://dx.doi.org/10.1016/S0006-3495(01)75924-3
