Citric Acid Cycle
From Proteopedia
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*[[Krebs cycle overview]] | *[[Krebs cycle overview]] | ||
*[[Krebs cycle reactions]] | *[[Krebs cycle reactions]] | ||
| + | *[[Major metabolic pathways converging on the citric acid cycle]] | ||
| + | *[[Citric acid cycle intermediates serve as substrates for biosynthetic processes]] | ||
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The [[Citric Acid Cycle]] (tricarboxylic acid cycle) is a series of enzyme catalyzed reactions which are critical in cellular respiration. Under oxidative conditions, pyruvate continues to be metabolized through the tricarboxylic acid cycle. In this cycle, Acetyl-CoA, a byproduct of [[glycolysis]], along with various cofactors, are broken down into carbon dioxide, water, and energy in the form of GTP and NADH. | The [[Citric Acid Cycle]] (tricarboxylic acid cycle) is a series of enzyme catalyzed reactions which are critical in cellular respiration. Under oxidative conditions, pyruvate continues to be metabolized through the tricarboxylic acid cycle. In this cycle, Acetyl-CoA, a byproduct of [[glycolysis]], along with various cofactors, are broken down into carbon dioxide, water, and energy in the form of GTP and NADH. | ||
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*2nd step of [[Krebs cycle step 3]] | *2nd step of [[Krebs cycle step 3]] | ||
6C Oxalosuccinate => 5C <scene name='43/430893/Cv/8'>α-Ketoglutarate</scene> | 6C Oxalosuccinate => 5C <scene name='43/430893/Cv/8'>α-Ketoglutarate</scene> | ||
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| + | The α-ketoglutarate family of amino acid synthesis (synthesis of glutamate, glutamine, proline and arginine) begins with α-ketoglutarate, an intermediate in the Citric Acid Cycle. See [[Alpha-Ketoglutarates: glutamate, glutamine, proline, arginine]] | ||
'''Step 5 - Oxidative decarboxylation - α-Ketoglutarate dehydrogenase (2-Oxoglutarate Dehydrogenase)''' | '''Step 5 - Oxidative decarboxylation - α-Ketoglutarate dehydrogenase (2-Oxoglutarate Dehydrogenase)''' | ||
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*[[Succinyl-CoA synthetase]] | *[[Succinyl-CoA synthetase]] | ||
*Step 6 = [[Krebs cycle step 5]] | *Step 6 = [[Krebs cycle step 5]] | ||
| + | Succinyl-CoA => <scene name='43/430893/Cv/10'>Succinate</scene> | ||
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| + | The succinyl-CoA formed during [[Beta oxidation]] can also enter the Citric Acid Cycle in this step. | ||
'''Step 7 - Oxidation - Succinate dehydrogenase''' | '''Step 7 - Oxidation - Succinate dehydrogenase''' | ||
*[[Succinate Dehydrogenase]] | *[[Succinate Dehydrogenase]] | ||
*Step 7 = [[Krebs cycle step 6]] | *Step 7 = [[Krebs cycle step 6]] | ||
| + | Succinate => <scene name='43/430893/Cv/11'>Fumarate</scene> | ||
'''Step 8 - Hydration - Fumarase''' | '''Step 8 - Hydration - Fumarase''' | ||
*[[Fumarase]] | *[[Fumarase]] | ||
*Step 8 = [[Krebs cycle step 7]] | *Step 8 = [[Krebs cycle step 7]] | ||
| + | Fumarate => <scene name='43/430893/Cv/12'>L-Malate</scene> | ||
'''Step 9 - Oxidation - Malate dehydrogenase''' | '''Step 9 - Oxidation - Malate dehydrogenase''' | ||
*[[Malate dehydrogenase]] | *[[Malate dehydrogenase]] | ||
*Step 9 = [[Krebs cycle step 8]] | *Step 9 = [[Krebs cycle step 8]] | ||
| + | L-Malate => <scene name='43/430893/Cv/3'>oxaloacetate</scene> | ||
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| + | Oxaloacetate takes part in [[gluconeogenesis]], the urea cycle, the glyoxylate cycle, amino acid synthesis ([[Oxaloacetate/aspartate: lysine, asparagine, methionine, threonine, and isoleucine]]), [[fatty acid synthesis]]. | ||
'''Step 10 / 0 - Aldol condensation - Citrate synthase''' | '''Step 10 / 0 - Aldol condensation - Citrate synthase''' | ||
*[[Citrate Synthase]] | *[[Citrate Synthase]] | ||
*Step 10 / 0 = [[Krebs cycle step 1]] | *Step 10 / 0 = [[Krebs cycle step 1]] | ||
| - | + | 4C <scene name='43/430893/Cv/3'>oxaloacetate</scene> to a 6C molecule <scene name='43/430893/Cv/4'>citrate</scene> | |
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To view automatically seeded indices concerning [[Citric Acid Cycle]] See: | To view automatically seeded indices concerning [[Citric Acid Cycle]] See: | ||
Current revision
Proteopedia Page Contributors and Editors (what is this?)
Alexander Berchansky, David Canner, Ann Taylor, Wayne Decatur, Jaime Prilusky
