This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Citric Acid Cycle
From Proteopedia
(Difference between revisions)
| (6 intermediate revisions not shown.) | |||
| Line 6: | Line 6: | ||
*[[Krebs cycle overview]] | *[[Krebs cycle overview]] | ||
*[[Krebs cycle reactions]] | *[[Krebs cycle reactions]] | ||
| + | *[[Major metabolic pathways converging on the citric acid cycle]] | ||
| + | *[[Citric acid cycle intermediates serve as substrates for biosynthetic processes]] | ||
| + | |||
The [[Citric Acid Cycle]] (tricarboxylic acid cycle) is a series of enzyme catalyzed reactions which are critical in cellular respiration. Under oxidative conditions, pyruvate continues to be metabolized through the tricarboxylic acid cycle. In this cycle, Acetyl-CoA, a byproduct of [[glycolysis]], along with various cofactors, are broken down into carbon dioxide, water, and energy in the form of GTP and NADH. | The [[Citric Acid Cycle]] (tricarboxylic acid cycle) is a series of enzyme catalyzed reactions which are critical in cellular respiration. Under oxidative conditions, pyruvate continues to be metabolized through the tricarboxylic acid cycle. In this cycle, Acetyl-CoA, a byproduct of [[glycolysis]], along with various cofactors, are broken down into carbon dioxide, water, and energy in the form of GTP and NADH. | ||
| Line 55: | Line 58: | ||
*Step 6 = [[Krebs cycle step 5]] | *Step 6 = [[Krebs cycle step 5]] | ||
Succinyl-CoA => <scene name='43/430893/Cv/10'>Succinate</scene> | Succinyl-CoA => <scene name='43/430893/Cv/10'>Succinate</scene> | ||
| + | |||
| + | The succinyl-CoA formed during [[Beta oxidation]] can also enter the Citric Acid Cycle in this step. | ||
'''Step 7 - Oxidation - Succinate dehydrogenase''' | '''Step 7 - Oxidation - Succinate dehydrogenase''' | ||
| Line 70: | Line 75: | ||
*Step 9 = [[Krebs cycle step 8]] | *Step 9 = [[Krebs cycle step 8]] | ||
L-Malate => <scene name='43/430893/Cv/3'>oxaloacetate</scene> | L-Malate => <scene name='43/430893/Cv/3'>oxaloacetate</scene> | ||
| - | + | ||
| + | Oxaloacetate takes part in [[gluconeogenesis]], the urea cycle, the glyoxylate cycle, amino acid synthesis ([[Oxaloacetate/aspartate: lysine, asparagine, methionine, threonine, and isoleucine]]), [[fatty acid synthesis]]. | ||
'''Step 10 / 0 - Aldol condensation - Citrate synthase''' | '''Step 10 / 0 - Aldol condensation - Citrate synthase''' | ||
| Line 76: | Line 82: | ||
*Step 10 / 0 = [[Krebs cycle step 1]] | *Step 10 / 0 = [[Krebs cycle step 1]] | ||
4C <scene name='43/430893/Cv/3'>oxaloacetate</scene> to a 6C molecule <scene name='43/430893/Cv/4'>citrate</scene> | 4C <scene name='43/430893/Cv/3'>oxaloacetate</scene> to a 6C molecule <scene name='43/430893/Cv/4'>citrate</scene> | ||
| - | |||
| - | [[Major metabolic pathways converging on the citric acid cycle]] | ||
| - | |||
| - | [[Citric acid cycle intermediates serve as substrates for biosynthetic processes]] | ||
To view automatically seeded indices concerning [[Citric Acid Cycle]] See: | To view automatically seeded indices concerning [[Citric Acid Cycle]] See: | ||
Current revision
Proteopedia Page Contributors and Editors (what is this?)
Alexander Berchansky, David Canner, Ann Taylor, Wayne Decatur, Jaime Prilusky
