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Main Page 20190127

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<big>Welcome to Proteopedia,</big>
 
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<div style="font-size:1.5em;border:1px solid #ddd;background-color:yellow;padding:10px;"><b>READ-ONLY Mode Mar 18-21 2017</b><br>Proteopedia will be in a READ-ONLY mode for Mar 18-21, 2017, in order to move Proteopedia to a better server. While Proteopedia is in READ-ONLY, it will be possible to search and browse the current pages, but creation or editing of pages will be disabled, and it will not be possible to create new userIDs during this period.
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{{STRUCTURE_1eve | PDB= 1eve | SCENE=Main_Page/E2020_in_ache_spinning/1 }}
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The collaborative, 3D encyclopedia of proteins and other molecules.
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<big>''Here's an excerpt from one of our pages ([[1eve]]):''</big>
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<span style="font-size:2.0em; border:none; margin:0; padding:0.3em; color:#000;">Welcome to Proteopedia</span>
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<span style="top:+0.2em; font-size:1.2em; padding-left:5px;">The free, collaborative 3D-encyclopedia of proteins & other molecules</span>
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<span style="font-size:1.5em; border:none; margin:0; padding:0.3em;font-weight:bold;"> [[Proteopedia:Table of Contents|Table of Contents]] * [[Proteopedia:Structure Index|Structure Index]] * [[Krebs_cycle_overview|Function to Structure]] * [[Proteopedia:About|About]] * [[Proteopedia:Video_Guide|Video Guide]] * [[Help:Contents|Help]]</span>
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The anti-Alzheimer's drug E2020 (marketed as Aricept&reg;) is an inhibitor that binds acetylcholinesterase (AChE) with high affinity. The X-ray structure of the E2020-AChE (AChE from ''Torpedo california'') complex shows that E2020 has a '''<scene name='1eve/E2020_close_up_with_84_279/10'>unique orientation</scene>''' along the active-site gorge, extending from the anionic subsite ('''<scene name='1eve/E2020_close_up_with_84lbld/5'>W84</scene>''') of the active site, at the bottom, to the peripheral anionic site ('''<scene name='1eve/E2020_close_up_with_84_279lbld/4'>near W279</scene>'''), at the top, via aromatic stacking interactions with conserved aromatic acid residues. E2020 does not, however, interact directly with either the catalytic triad or the 'oxyanion hole' but only '''<scene name='1eve/E20_interactionshown/7'>indirectly via solvent molecules</scene>'''.
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* [[1v04 | Serum Paraoxonase-1 created by directed evolution]].
 
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On the page '''[[Proteopedia:About | About Proteopedia]]''' you will find information about the contents, implementation, policies and credits.
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Proudly show your love for Proteopedia and help spread Proteopedia's wonders with mugs and t-shirts from [http://www.cafepress.com/molviz4 cafepress.com].
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Graphics by [[User:Eric_Martz|Eric Martz]], based on the original Proteopedia logo by Tali Wiesel. Cafepress is a website that prints images on mugs and t-shirts, and is unaffiliated with Proteopedia. We've used the website to design high quality Proteopedia mugs and t-shirts, and all articles are sold at the standard price set by Cafepress. Proteopedia collects no money from your purchase.
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Current revision


Proteopedia Page Contributors and Editors (what is this?)

Eran Hodis, Eric Martz, Joel L. Sussman, Jaime Prilusky, David Canner

Retrieved from "http://52.214.119.220/wiki/index.php/Main_Page_20190127"
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