Amyloid beta

(Difference between revisions)

Revision as of 03:21, 26 November 2011

@@ Line 1: / Line 1: @@
 <StructureSection load=1iyt size='500' side='right' caption='amyloid-beta(1-42)', ([[1dm0]])' scene=''>
 ==Introduction==
-'''Alzheimer's disease''' is characterized by extracellular proteic plaques and intracellular neurofibrillary tangles.<ref name="structure">PMID: 12423364</ref> These plaques are collections of fibrils consisting mostly of beta-amyloid <scene name='Amyloid_beta/Fibrils/1'>fibrils</scene>. These fibril are aggregates of beta-sheets though amyloid betam can also form alpha helices that create pores in the membrane that trigger cell death.<ref name="structure" />
+'''Alzheimer's disease''' is characterized by extracellular proteic plaques and intracellular neurofibrillary tangles.<ref name="structure">PMID: 12423364</ref> These plaques are collections of fibrils consisting mostly of beta-amyloid <scene name='Amyloid_beta/Fibrils/1'>fibrils</scene>. These fibrils are aggregates of beta-sheets. The oxidative stress that an affected brain is under is further proof of the toxicity of amyloid beta. When amyloid beta is in contact with metal ions and oxygen reactive oxygen species (especially hydrogen peroxide) are created. <ref name="alz">PMID:18305836</ref>
 '''Amyloids''' are insoluble fibrous proteins