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Troponin
From Proteopedia
(Difference between revisions)
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{{STRUCTURE_1yv0| PDB=1yv0 | SIZE=400| SCENE=Troponin/Cv/1 |right|CAPTION=Chicken troponin: subunit T (dark green), subunit I (wheat), subunit C (pink) complex with Mg+2 ion (green) [[1yv0]] }} | {{STRUCTURE_1yv0| PDB=1yv0 | SIZE=400| SCENE=Troponin/Cv/1 |right|CAPTION=Chicken troponin: subunit T (dark green), subunit I (wheat), subunit C (pink) complex with Mg+2 ion (green) [[1yv0]] }} | ||
| - | + | == Function == | |
[[Troponin]] (Tn) is a regulatory protein in muscle contraction. It contains 3 subunits:<br /> | [[Troponin]] (Tn) is a regulatory protein in muscle contraction. It contains 3 subunits:<br /> | ||
| - | * '''TnC''' causes conformational change in TnI when it binds to calcium ions. For more details on TnC see<br /> | + | * '''TnC''' causes conformational change in TnI when it binds to calcium ions<ref>PMID:26232335</ref>. For more details on TnC see<br /> |
[[ Role of Troponin C in decreased muscle sensitivity to calcium]]<br /> | [[ Role of Troponin C in decreased muscle sensitivity to calcium]]<br /> | ||
[[Human Cardiac Troponin C]]<br /> | [[Human Cardiac Troponin C]]<br /> | ||
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* '''TnT''' binds to [[Tropomyosin|tropomyosin]].<br /> | * '''TnT''' binds to [[Tropomyosin|tropomyosin]].<br /> | ||
* '''TnI''' binds to actin which is found in thin muscle filaments.<br /> | * '''TnI''' binds to actin which is found in thin muscle filaments.<br /> | ||
| + | |||
| + | == Disease == | ||
| + | Mutations in TnI<ref>PMID:9241277</ref> and TnT <ref>PMID:11606294</ref>are associated with hypertrophic cardiomyopathy. | ||
== 3D Structures of Troponin == | == 3D Structures of Troponin == | ||
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**[[2z5h]] – yTnT fragment+tropomyosin – yeast | **[[2z5h]] – yTnT fragment+tropomyosin – yeast | ||
}} | }} | ||
| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:21, 26 September 2016
Contents |
Function
Troponin (Tn) is a regulatory protein in muscle contraction. It contains 3 subunits:
- TnC causes conformational change in TnI when it binds to calcium ions[1]. For more details on TnC see
Role of Troponin C in decreased muscle sensitivity to calcium
Human Cardiac Troponin C
Human Cardiac Troponin C in complex with the Green Tea Polyphenol
- TnT binds to tropomyosin.
- TnI binds to actin which is found in thin muscle filaments.
Disease
Mutations in TnI[2] and TnT [3]are associated with hypertrophic cardiomyopathy.
3D Structures of Troponin
Updated on 26-September-2016
References
- ↑ Li MX, Hwang PM. Structure and function of cardiac troponin C (TNNC1): Implications for heart failure, cardiomyopathies, and troponin modulating drugs. Gene. 2015 Oct 25;571(2):153-66. doi: 10.1016/j.gene.2015.07.074. Epub 2015 Jul, 29. PMID:26232335 doi:http://dx.doi.org/10.1016/j.gene.2015.07.074
- ↑ Kimura A, Harada H, Park JE, Nishi H, Satoh M, Takahashi M, Hiroi S, Sasaoka T, Ohbuchi N, Nakamura T, Koyanagi T, Hwang TH, Choo JA, Chung KS, Hasegawa A, Nagai R, Okazaki O, Nakamura H, Matsuzaki M, Sakamoto T, Toshima H, Koga Y, Imaizumi T, Sasazuki T. Mutations in the cardiac troponin I gene associated with hypertrophic cardiomyopathy. Nat Genet. 1997 Aug;16(4):379-82. PMID:9241277 doi:10.1038/ng0897-379
- ↑ Palm T, Graboski S, Hitchcock-DeGregori SE, Greenfield NJ. Disease-causing mutations in cardiac troponin T: identification of a critical tropomyosin-binding region. Biophys J. 2001 Nov;81(5):2827-37. PMID:11606294 doi:http://dx.doi.org/10.1016/S0006-3495(01)75924-3
