Microtubule-associated protein
From Proteopedia
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<StructureSection load='2zjd' size='340' side='right' caption='Human microtubule-associated protein light chain 3B (grey and pink) complex with sequestosome peptide (green and yellow) (PDB code [[2zjd]])' scene=''> | <StructureSection load='2zjd' size='340' side='right' caption='Human microtubule-associated protein light chain 3B (grey and pink) complex with sequestosome peptide (green and yellow) (PDB code [[2zjd]])' scene=''> | ||
| - | '''Microtubule-associated protein light chain 3''' (LC3) is recruited to autophagosomal membranes during autophagy. The human LC3B is cleaved after synthesis to expose a C-terminal glycine which binds via a phospholipid anchor to autophagosomal vescicle membranes during autophagy. Thus detection of LC3 is a reliable method for monitoring autophagy. The microtubule-associated proteins are classsified as 2 types. Type 1 includes MAP1 and type 2 includes MAP2, MAP4 and [[Tau protein]]. | ||
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== Function == | == Function == | ||
| + | '''Microtubule-associated protein light chain 3''' (LC3) is recruited to autophagosomal membranes during autophagy<ref>PMID:7480164</ref>. The human LC3B is cleaved after synthesis to expose a C-terminal glycine which binds via a phospholipid anchor to autophagosomal vesicle membranes during autophagy. Thus detection of LC3 is a reliable method for monitoring autophagy. The microtubule-associated proteins are classified as 2 types. Type 1 includes MAP1 and type 2 includes MAP2, MAP4 and [[Tau protein]]. | ||
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| + | *'''MAP1''' are classical microtubule-associated proteins which bind along microtubule lattice<ref>PMID:16938900</ref>.<br /> | ||
| + | *'''Tau protein''' is the principal component of the tangles found in Alzheimer's disease. It is hyperphosphorylated on serines and threonines<ref>PMID:19542604</ref>. | ||
== Disease == | == Disease == | ||
| - | + | '''Microtubule-associated protein Tau''' is associated with Alzheimer Disease. Tau forms abnormal aggregates in patients' tissues. Mutations in tau protein are associated with neurodegenerative diseases like frontotemporal dementia<ref>PMID:15056452</ref>. | |
| - | '''Microtubule-associated protein Tau''' is associated with Alzheimer Disease. Tau forms abnormal aggregates in patients' tissues. | + | |
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== Structural highlights == | == Structural highlights == | ||
Revision as of 09:39, 27 April 2016
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3D Structures of microtubule-associated protein
Updated on 27-April-2016
References
- ↑ Maccioni RB, Cambiazo V. Role of microtubule-associated proteins in the control of microtubule assembly. Physiol Rev. 1995 Oct;75(4):835-64. PMID:7480164
- ↑ Halpain S, Dehmelt L. The MAP1 family of microtubule-associated proteins. Genome Biol. 2006;7(6):224. PMID:16938900
- ↑ Lebouvier T, Scales TM, Williamson R, Noble W, Duyckaerts C, Hanger DP, Reynolds CH, Anderton BH, Derkinderen P. The microtubule-associated protein tau is also phosphorylated on tyrosine. J Alzheimers Dis. 2009;18(1):1-9. doi: 10.3233/JAD-2009-1116. PMID:19542604 doi:http://dx.doi.org/10.3233/JAD-2009-1116
- ↑ Schraen-Maschke S, Dhaenens CM, Delacourte A, Sablonniere B. Microtubule-associated protein tau gene: a risk factor in human neurodegenerative diseases. Neurobiol Dis. 2004 Apr;15(3):449-60. PMID:15056452 doi:http://dx.doi.org/10.1016/j.nbd.2003.12.009
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