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Troponin

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{{STRUCTURE_1yv0| PDB=1yv0 | SIZE=400| SCENE=Troponin/Cv/1 |right|CAPTION=Chicken troponin: subunit T (dark green), subunit I (wheat), subunit C (pink) complex with Mg+2 ion (green) [[1yv0]] }}
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<StructureSection load='1yv0' size='340' side='right' caption='Chicken troponin: subunit T (dark green), subunit I (wheat), subunit C (pink) complex with Mg+2 ion (green) [[1yv0]]' scene=''>
== Function ==
== Function ==
[[Troponin]] (Tn) is a regulatory protein in muscle contraction. It contains 3 subunits:<br />
[[Troponin]] (Tn) is a regulatory protein in muscle contraction. It contains 3 subunits:<br />
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== Disease ==
== Disease ==
Mutations in TnI<ref>PMID:9241277</ref> and TnT <ref>PMID:11606294</ref>are associated with hypertrophic cardiomyopathy.
Mutations in TnI<ref>PMID:9241277</ref> and TnT <ref>PMID:11606294</ref>are associated with hypertrophic cardiomyopathy.
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</StructureSection>
== 3D Structures of Troponin ==
== 3D Structures of Troponin ==
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* Troponin C+Troponin I
* Troponin C+Troponin I
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**[[2krd]], [[2mkp]] – hTnC+hTnI – NMR<br />
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**[[2krd]], [[2mkp]] – hTnC+hTnI + Ca – NMR<br />
**[[1ozs]] - hTnC C-terminal+hTnI N-terminal – NMR<br />
**[[1ozs]] - hTnC C-terminal+hTnI N-terminal – NMR<br />
**[[2l1r]] - hTnC C-terminal+hTnI switch region - NMR<br />
**[[2l1r]] - hTnC C-terminal+hTnI switch region - NMR<br />
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**[[1lxf]], [[1mxl]] - hTnC N-terminal+hTnI fragment<br />
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**[[1lxf]], [[1mxl]] - hTnC N-terminal+hTnI fragment - NMR<br />
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**[[2kgb]] – hTnC (mutant) regulatory domain+TnI<br />
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**[[2kgb]] – hTnC (mutant) regulatory domain+TnI - NMR<br />
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**[[2mzp]] - hTnC regulatory domain+TnI switch region (mutant) <br />
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**[[2mzp]] - hTnC regulatory domain+TnI switch region (mutant) - NMR<br />
**[[1sbj]] – cTnC C-terminal+cTnI N-terminal+Mg - NMR<br />
**[[1sbj]] – cTnC C-terminal+cTnI N-terminal+Mg - NMR<br />
**[[1scv]], [[1fi5]], [[1blq]] - cTnC C-terminal+cTnI N-terminal – NMR<br />
**[[1scv]], [[1fi5]], [[1blq]] - cTnC C-terminal+cTnI N-terminal – NMR<br />

Revision as of 10:00, 26 September 2016

Chicken troponin: subunit T (dark green), subunit I (wheat), subunit C (pink) complex with Mg+2 ion (green) 1yv0

Drag the structure with the mouse to rotate

3D Structures of Troponin

Updated on 26-September-2016

References

  1. ↑ Li MX, Hwang PM. Structure and function of cardiac troponin C (TNNC1): Implications for heart failure, cardiomyopathies, and troponin modulating drugs. Gene. 2015 Oct 25;571(2):153-66. doi: 10.1016/j.gene.2015.07.074. Epub 2015 Jul, 29. PMID:26232335 doi:http://dx.doi.org/10.1016/j.gene.2015.07.074
  2. ↑ Kimura A, Harada H, Park JE, Nishi H, Satoh M, Takahashi M, Hiroi S, Sasaoka T, Ohbuchi N, Nakamura T, Koyanagi T, Hwang TH, Choo JA, Chung KS, Hasegawa A, Nagai R, Okazaki O, Nakamura H, Matsuzaki M, Sakamoto T, Toshima H, Koga Y, Imaizumi T, Sasazuki T. Mutations in the cardiac troponin I gene associated with hypertrophic cardiomyopathy. Nat Genet. 1997 Aug;16(4):379-82. PMID:9241277 doi:10.1038/ng0897-379
  3. ↑ Palm T, Graboski S, Hitchcock-DeGregori SE, Greenfield NJ. Disease-causing mutations in cardiac troponin T: identification of a critical tropomyosin-binding region. Biophys J. 2001 Nov;81(5):2827-37. PMID:11606294 doi:http://dx.doi.org/10.1016/S0006-3495(01)75924-3

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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