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Troponin
From Proteopedia
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<StructureSection load='1yv0' size='340' side='right' caption='Chicken troponin: subunit T (dark green), subunit I (wheat), subunit C (pink) complex with Mg+2 ion (green) [[1yv0]]' scene=''> | <StructureSection load='1yv0' size='340' side='right' caption='Chicken troponin: subunit T (dark green), subunit I (wheat), subunit C (pink) complex with Mg+2 ion (green) [[1yv0]]' scene=''> | ||
== Function == | == Function == | ||
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**[[2l1r]] - hTnC C-terminal+hTnI switch region - NMR<br /> | **[[2l1r]] - hTnC C-terminal+hTnI switch region - NMR<br /> | ||
**[[1lxf]], [[1mxl]] - hTnC N-terminal+hTnI fragment - NMR<br /> | **[[1lxf]], [[1mxl]] - hTnC N-terminal+hTnI fragment - NMR<br /> | ||
| + | **[[2n7l]] - hTnC N-terminal/hTnC switch + drug analog – NMR<br /> | ||
**[[2kgb]] – hTnC (mutant) regulatory domain+TnI - NMR<br /> | **[[2kgb]] – hTnC (mutant) regulatory domain+TnI - NMR<br /> | ||
**[[2mzp]] - hTnC regulatory domain+TnI switch region (mutant) - NMR<br /> | **[[2mzp]] - hTnC regulatory domain+TnI switch region (mutant) - NMR<br /> | ||
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**[[2kfx]] – hTnC (mutant) N-terminal+Ca+naphthalene derivative<br /> | **[[2kfx]] – hTnC (mutant) N-terminal+Ca+naphthalene derivative<br /> | ||
**[[2jt0]], [[2jtz]], [[2jt8]], [[2jt3]] – hTnC (mutant) – NMR<br /> | **[[2jt0]], [[2jtz]], [[2jt8]], [[2jt3]] – hTnC (mutant) – NMR<br /> | ||
| - | **[[2jxl]] - hTnC (mutant) N-terminal – NMR<br /> | + | **[[2jxl]], [[2n79]] - hTnC (mutant) N-terminal + Ca – NMR<br /> |
**[[3rv5]], [[3sd6]], [[3swb]], [[4gje]] - hTnC N-terminal<br /> | **[[3rv5]], [[3sd6]], [[3swb]], [[4gje]] - hTnC N-terminal<br /> | ||
**[[4gjg]] - hTnC N-terminal (mutant)<br /> | **[[4gjg]] - hTnC N-terminal (mutant)<br /> | ||
Revision as of 10:12, 26 September 2016
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3D Structures of Troponin
Updated on 26-September-2016
References
- ↑ Li MX, Hwang PM. Structure and function of cardiac troponin C (TNNC1): Implications for heart failure, cardiomyopathies, and troponin modulating drugs. Gene. 2015 Oct 25;571(2):153-66. doi: 10.1016/j.gene.2015.07.074. Epub 2015 Jul, 29. PMID:26232335 doi:http://dx.doi.org/10.1016/j.gene.2015.07.074
- ↑ Kimura A, Harada H, Park JE, Nishi H, Satoh M, Takahashi M, Hiroi S, Sasaoka T, Ohbuchi N, Nakamura T, Koyanagi T, Hwang TH, Choo JA, Chung KS, Hasegawa A, Nagai R, Okazaki O, Nakamura H, Matsuzaki M, Sakamoto T, Toshima H, Koga Y, Imaizumi T, Sasazuki T. Mutations in the cardiac troponin I gene associated with hypertrophic cardiomyopathy. Nat Genet. 1997 Aug;16(4):379-82. PMID:9241277 doi:10.1038/ng0897-379
- ↑ Palm T, Graboski S, Hitchcock-DeGregori SE, Greenfield NJ. Disease-causing mutations in cardiac troponin T: identification of a critical tropomyosin-binding region. Biophys J. 2001 Nov;81(5):2827-37. PMID:11606294 doi:http://dx.doi.org/10.1016/S0006-3495(01)75924-3
