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Troponin

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Line 22: Line 22:
**[[1ytz]] - cTnC+cTnI+cTnT+Ca<br />
**[[1ytz]] - cTnC+cTnI+cTnT+Ca<br />
**[[1yv0]] - cTnC+cTnI+cTnT<br />
**[[1yv0]] - cTnC+cTnI+cTnT<br />
-
**[[1j1d]], [[1j1e]] – hTnC (mutant)+hTnI (mutant) fragment+hTnT fragment+Ca - human
+
**[[1j1d]], [[1j1e]], [[4y99]] – hTnC (mutant)+hTnI (mutant) fragment+hTnT fragment+Ca - human
* Troponin C+Troponin I
* Troponin C+Troponin I
Line 43: Line 43:
**[[2kdh]] – hTnC+green tea polyphenol – NMR<br />
**[[2kdh]] – hTnC+green tea polyphenol – NMR<br />
-
**[[2kfx]] – hTnC (mutant) N-terminal+Ca+naphthalene derivative<br />
 
**[[2jt0]], [[2jtz]], [[2jt8]], [[2jt3]] – hTnC (mutant) – NMR<br />
**[[2jt0]], [[2jtz]], [[2jt8]], [[2jt3]] – hTnC (mutant) – NMR<br />
-
**[[2jxl]], [[2n79]] - hTnC (mutant) N-terminal + Ca – NMR<br />
+
**[[3rv5]], [[3sd6]], [[3swb]], [[4gje]], [[1spy]] - hTnC N-terminal<br />
-
**[[3rv5]], [[3sd6]], [[3swb]], [[4gje]] - hTnC N-terminal<br />
+
**[[4gjg]], [[5vln]] - hTnC N-terminal (mutant)<br />
-
**[[4gjg]] - hTnC N-terminal (mutant)<br />
+
**[[1ap4]] - hTnC N-terminal+Ca – NMR<br />
 +
**[[2jxl]], [[2n79]] - hTnC N-terminal (mutant) + Ca – NMR<br />
**[[4gjf]] - hTnC N-terminal (mutant) + Cd<br />
**[[4gjf]] - hTnC N-terminal (mutant) + Cd<br />
-
**[[1wrk]], [[1wrl]] - hTnC (mutant) N-terminal+trifluoperazine<br />
+
**[[1wrk]], [[1wrl]] - hTnC N-terminal (mutant) +trifluoperazine<br />
-
**[[1spy]] - hTnC N-terminal – NMR<br />
+
**[[5w88]], [[5wcl]] - hTnC N-terminal (mutant) + methyldiphenylamine - NMR<br />
 +
**[[2kfx]] – hTnC (mutant) N-terminal+Ca+naphthalene derivative<br />
**[[2mle]] - hTnC C-terminal – NMR<br />
**[[2mle]] - hTnC C-terminal – NMR<br />
**[[2mlf]] - hTnC C-terminal (mutant) – NMR<br />
**[[2mlf]] - hTnC C-terminal (mutant) – NMR<br />
**[[1ih0]] - hTnC C-terminal+EMD 57033 – NMR<br />
**[[1ih0]] - hTnC C-terminal+EMD 57033 – NMR<br />
-
**[[1ap4]] - hTnC N-terminal+Ca – NMR<br />
 
**[[2l98]] – hTnC EF-hand domains 3,4 + resveratrol<br />
**[[2l98]] – hTnC EF-hand domains 3,4 + resveratrol<br />
**[[1la0]], [[4tnc]] – cTnC+Ca<br />
**[[1la0]], [[4tnc]] – cTnC+Ca<br />

Revision as of 21:45, 11 October 2017

Chicken troponin: subunit T (dark green), subunit I (wheat), subunit C (pink) complex with Mg+2 ion (green) 1yv0

Drag the structure with the mouse to rotate

3D Structures of Troponin

Updated on 11-October-2017

References

  1. ↑ Li MX, Hwang PM. Structure and function of cardiac troponin C (TNNC1): Implications for heart failure, cardiomyopathies, and troponin modulating drugs. Gene. 2015 Oct 25;571(2):153-66. doi: 10.1016/j.gene.2015.07.074. Epub 2015 Jul, 29. PMID:26232335 doi:http://dx.doi.org/10.1016/j.gene.2015.07.074
  2. ↑ Kimura A, Harada H, Park JE, Nishi H, Satoh M, Takahashi M, Hiroi S, Sasaoka T, Ohbuchi N, Nakamura T, Koyanagi T, Hwang TH, Choo JA, Chung KS, Hasegawa A, Nagai R, Okazaki O, Nakamura H, Matsuzaki M, Sakamoto T, Toshima H, Koga Y, Imaizumi T, Sasazuki T. Mutations in the cardiac troponin I gene associated with hypertrophic cardiomyopathy. Nat Genet. 1997 Aug;16(4):379-82. PMID:9241277 doi:10.1038/ng0897-379
  3. ↑ Palm T, Graboski S, Hitchcock-DeGregori SE, Greenfield NJ. Disease-causing mutations in cardiac troponin T: identification of a critical tropomyosin-binding region. Biophys J. 2001 Nov;81(5):2827-37. PMID:11606294 doi:http://dx.doi.org/10.1016/S0006-3495(01)75924-3

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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