Microtubule-associated protein

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 5: Line 5:
*'''MAP1''' are classical microtubule-associated proteins which bind along microtubule lattice<ref>PMID:16938900</ref>.<br />
*'''MAP1''' are classical microtubule-associated proteins which bind along microtubule lattice<ref>PMID:16938900</ref>.<br />
*'''Tau protein''' is the principal component of the tangles found in Alzheimer's disease. It is hyperphosphorylated on serines and threonines<ref>PMID:19542604</ref>.
*'''Tau protein''' is the principal component of the tangles found in Alzheimer's disease. It is hyperphosphorylated on serines and threonines<ref>PMID:19542604</ref>.
 +
*'''Microtubule-associated protein RP/EB family member 1''' (MAPRE1) is involved in the regulation of microtubule structure and chromosome stability. It associates with dynactin and the spindle during mitosis<ref>PMID:22919</ref>.
 +
*'''Microtubule-associated protein RP/EB family member 3''' (MAPRE3) localizes to the cytoplasmic microtubule network and binds a homolog of the adenomatous polyposis coli tumor suppressor gene<ref>PMID:22924</ref>.
== Disease ==
== Disease ==
Line 63: Line 65:
**[[4glr]], [[4tqe]], [[5dmg]] – hTau peptide + antibody<br />
**[[4glr]], [[4tqe]], [[5dmg]] – hTau peptide + antibody<br />
**[[4fl5]], [[4y32]], [[4y3b]], [[4y5i]] – hTau peptide + 14-3-3 protein σ<br />
**[[4fl5]], [[4y32]], [[4y3b]], [[4y5i]] – hTau peptide + 14-3-3 protein σ<br />
 +
 +
*Microtubule-associated protein RP/EB family member 1
 +
 +
**[[1wu9]] – hMAPRE1 C-terminal<br />
 +
**[[1yib]], [[1yig]] – hMAPRE1 C-terminal dimerization domain<br />
 +
**[[1vka]], [[2r8u]], [[1pa7]], [[1ueg]] – hMAPRE1 N-terminal<br />
 +
**[[2qjz]] – hMAPRE1 CH domain <br />
 +
**[[3gjo]] – hMAPRE1 C-terminal + dystonin peptide<br />
 +
**[[1txq]], [[2hkq]], [[2hl5]] – hMAPRE1 C-terminal + dynactin CAP-Gly domain<br />
 +
**[[3tq7]] – hMAPRE1 C-terminal + hRPEB member 3 C-terminal + dynactin CAP-Gly domain<br />
 +
 +
*Microtubule-associated protein RP/EB family member 3
 +
 +
**[[1v5k]] – mMAPRE3 CH domain - NMR<br />
 +
**[[3co1]] – hMAPRE3 CH domain <br />
 +
**[[1wyo]] – hMAPRE3 CH domain - NMR<br />
 +
**[[3jak]], [[3jal]], [[3gar]] – hMAPRE3 CH domain + tubulin + 3GTP – Cryo EM<br />
}}
}}

Revision as of 12:00, 10 December 2017

Human microtubule-associated protein light chain 3B (cyan) complex with sequestosome peptide (green) (PDB code 2zjd)

Drag the structure with the mouse to rotate

3D Structures of microtubule-associated protein

Updated on 10-December-2017

References

  1. ↑ Maccioni RB, Cambiazo V. Role of microtubule-associated proteins in the control of microtubule assembly. Physiol Rev. 1995 Oct;75(4):835-64. PMID:7480164
  2. ↑ Halpain S, Dehmelt L. The MAP1 family of microtubule-associated proteins. Genome Biol. 2006;7(6):224. PMID:16938900
  3. ↑ Lebouvier T, Scales TM, Williamson R, Noble W, Duyckaerts C, Hanger DP, Reynolds CH, Anderton BH, Derkinderen P. The microtubule-associated protein tau is also phosphorylated on tyrosine. J Alzheimers Dis. 2009;18(1):1-9. doi: 10.3233/JAD-2009-1116. PMID:19542604 doi:http://dx.doi.org/10.3233/JAD-2009-1116
  4. ↑ Buligescu L, Lenkei R, Ciontea M, Dan EM. [Significance of anti-albumin antibodies in chronic liver disease]. Rev Med Interna Neurol Psihiatr Neurochir Dermatovenerol Med Interna. 1977, Jul-Aug;29(4):363-70. PMID:22919
  5. ↑ Turtola LO. Enamel microhardness and fluoride uptake underneath fermenting and non-fermenting artificial plaque. Scand J Dent Res. 1977 Sep;85(6):373-9. PMID:22924
  6. ↑ Schraen-Maschke S, Dhaenens CM, Delacourte A, Sablonniere B. Microtubule-associated protein tau gene: a risk factor in human neurodegenerative diseases. Neurobiol Dis. 2004 Apr;15(3):449-60. PMID:15056452 doi:http://dx.doi.org/10.1016/j.nbd.2003.12.009
  7. ↑ Ichimura Y, Kumanomidou T, Sou YS, Mizushima T, Ezaki J, Ueno T, Kominami E, Yamane T, Tanaka K, Komatsu M. Structural basis for sorting mechanism of p62 in selective autophagy. J Biol Chem. 2008 Aug 15;283(33):22847-57. Epub 2008 Jun 4. PMID:18524774 doi:http://dx.doi.org/M802182200

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky

Retrieved from "http://52.214.119.220/wiki/index.php/Microtubule-associated_protein"
Personal tools