1l8w

From Proteopedia

(Difference between revisions)

Revision as of 07:56, 25 November 2020

Crystal Structure of Lyme Disease Variable Surface Antigen VlsE of Borrelia burgdorferi

Structural highlights

1l8w is a 4 chain structure with sequence from Atcc 35210. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
NonStd Res:
Gene:	vlsE (ATCC 35210)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[O06878_BORBG] The Vlp and Vsp proteins are antigenically distinct proteins, only one vlp or vsp gene is transcriptionally active at any one time. Switching between these genes is a mechanism of host immune response evasion.[RuleBase:RU363105]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

VlsE is an outer surface lipoprotein of Borrelia burgdorferi that undergoes antigenic variation through an elaborate gene conversion mechanism and is thought to play a major role in the immune response to the Lyme disease borellia. The crystal structure of recombinant variant protein VlsE1 at 2.3-A resolution reveals that the six variable regions form loop structures that constitute most of the membrane distal surface of VlsE, covering the predominantly alpha-helical, invariant regions of the protein. The surface localization of the variable amino acid segments appears to protect the conserved regions from interaction with antibodies and hence may contribute to immune evasion.

Crystal structure of Lyme disease variable surface antigen VlsE of Borrelia burgdorferi.,Eicken C, Sharma V, Klabunde T, Lawrenz MB, Hardham JM, Norris SJ, Sacchettini JC J Biol Chem. 2002 Jun 14;277(24):21691-6. Epub 2002 Mar 28. PMID:11923306^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Eicken C, Sharma V, Klabunde T, Lawrenz MB, Hardham JM, Norris SJ, Sacchettini JC. Crystal structure of Lyme disease variable surface antigen VlsE of Borrelia burgdorferi. J Biol Chem. 2002 Jun 14;277(24):21691-6. Epub 2002 Mar 28. PMID:11923306 doi:10.1074/jbc.M201547200

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1l8w"

@@ Line 1: / Line 1: @@
 ==Crystal Structure of Lyme Disease Variable Surface Antigen VlsE of Borrelia burgdorferi==
-<StructureSection load='1l8w' size='340' side='right' caption='[[1l8w]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
+<StructureSection load='1l8w' size='340' side='right'caption='[[1l8w]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1l8w]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_35210 Atcc 35210]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L8W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L8W FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1l8w]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_35210 Atcc 35210]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L8W OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1L8W FirstGlance]. <br>
 </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
 <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">vlsE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=139 ATCC 35210])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l8w OCA], [http://pdbe.org/1l8w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1l8w RCSB], [http://www.ebi.ac.uk/pdbsum/1l8w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1l8w ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1l8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l8w OCA], [http://pdbe.org/1l8w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1l8w RCSB], [http://www.ebi.ac.uk/pdbsum/1l8w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1l8w ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 31: / Line 31: @@
 ==See Also==
-*[[==VlsE==|==VlsE==]]
 *[[SB2013 L04gr5|SB2013 L04gr5]]
 *[[StudioG24SecL04Tpc5|StudioG24SecL04Tpc5]]
 *[[User:Marvin O'Neal/VlsE|User:Marvin O'Neal/VlsE]]
+*[[VlsE|VlsE]]
+*[[VlsE of Borrelia|VlsE of Borrelia]]
 == References ==
 <references/>
@@ Line 40: / Line 41: @@
 </StructureSection>
 [[Category: Atcc 35210]]
+[[Category: Large Structures]]
 [[Category: Eicken, C]]
 [[Category: Hardham, J M]]

1l8w

From Proteopedia

Revision as of 07:56, 25 November 2020

Crystal Structure of Lyme Disease Variable Surface Antigen VlsE of Borrelia burgdorferi

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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