Tyrosine kinase 3D structures

From Proteopedia

Revision as of 07:32, 14 June 2022

3D structures of tyrosine kinase

Updated on 14-June-2022 - For a general description of the protein see Tyrosine kinase {{#tree:id=OrganizedByTopic|openlevels=0|

• NON-RECEPTOR TYROSINE KINASES - nRTK

• Fyn tyrosine kinase (Domains: SH3 80-141; SH2 142-247; kinase 260-537)

• • 1shf, 3ua6, 7a2j, 7a2k – hTK Fyn SH3 domain – human
    
  • 3h0f, 3h0h, 3h0i, 3cqt, 6ipz, 6ipy, 7a2l, 7a2m, 7a2n, 7a2o, 7a2p, 7a2q, 7a2r,7a2s, 7a2t, 7a2u, 7a2v - hTK Fyn SH3 domain (mutant)
    
  • 1zbj - hTK Fyn SH3 domain – NMR
    
  • 1g83 - hTK Fyn SH2+SH3 domains (mutant)
    
  • 6edf - hTK Fyn residues 1-77
    
  • 3uf4 – mTK Fyn SH3-SH2 domain – mouse
    
  • 3uf4 - mTK Fyn SH2+SH3 domains
    
  • 2l2p, 2lp5 - cTK Fyn SH3 domain (mutant)- chicken - NMR
    

• Fyn complex

• • 1fyn, 4znx - hTK Fyn SH3 domain + peptide
    
  • 1nyf, 1nyg, 1a0n, 1azg - hTK Fyn SH3 domain + peptide – NMR
    
  • 1efn, 1avz - hTK Fyn SH3 domain + HIV Nef protein
    
  • 4d8d, 7d7s - hTK Fyn SH3 domain (mutant) + HIV Nef protein
    
  • 1m27 - hTK Fyn SH3 domain + SH2 domain protein 1A + SLAM peptide
    
  • 4d8d - hTK Fyn SH3 domain (mutant) + HIV Nef protein
    
  • 3ua7 – hTK Fyn SH3 domain + hepatitis virus peptide
    
  • 4eik - hTK Fyn SH3 domain + VSL12 peptide
    
  • 7a2w, 7a2x, 7a2y, 7a2z - hTK Fyn SH3 domain (mutant) + VSL12 peptide
    
  • 1aot, 1aou - hTK Fyn SH2 domain + phosphopeptide - NMR
    
  • 2dq7 – hTK kinase domain + staurosporine
    

• Abelson tyrosine kinase

• Abl1 SH2 domain residues 120-220

• • 1ab2 - hTK SH2 domain – NMR
    
  • 3uyo, 3t04, 3k2m, 5dc4, 5dc9 - hTK SH2 domain + monobody
    

• Abl1 SH3 domain residues 60-121

• • 5oaz - hTK SH3 domain
    
  • 1ju5 - hTK SH3 domain (mutant) + CRK SH2 domain + phosphopeptide - NMR
    
  • 1awo - hTK SH3 domain + phosphopeptide – NMR
    
  • 1bbz - hTK SH3 domain + peptide
    
  • 2o88 - hTK SH3 domain (mutant} + peptide
    
  • 4jjb, 4jjc, 4jjd - hTK abl SH3 domain
    
  • 4j9b, 3egu, 3eg2, 3eg3, 3eg0, 3eg1 - hTK abl SH3 domain (mutant)
    
  • 4j9c, 4j9e, 4j9i - hTK abl SH3 domain (mutant) + p17 peptide
    
  • 4j9d, 4j9f - hTK abl SH3 domain (mutant) + p0 peptide
    
  • 4j9g, 4j9h - hTK abl SH3 domain (mutant) + p7 peptide
    
  • 1abo - mTK SH3 domain + peptide
    
  • 1abq - mTK SH3 domain
    

• Abl1 SH3-SH2 domain residues 57-218

• • 2abl - hTK SH3-SH2 domain
    
  • 2fo0 - hTK SH3-SH2 domain (mutant)
    

• Abl1 regultory module residues 1-255

• • 6amv, 6amw - hTK
    

• Abl1 kinase domain residues 229-512

• • 6bl8 - hTK kinase domain
    
  • 2g2h - hTK kinase domain (mutant)
    
  • 6xr6, 6xr7, 6xrg - hTK kinase domain (mutant) - NMR
    
  • 2g1t - hTK kinase domain + peptide
    
  • 2g2i, 2g2f - hTK kinase domain (mutant) + peptide
    
  • 3ue4, 3cs9, 2hzi, 2hz4, 2hz0, 2hyy, 2gqg, 4wa9, 7n9g - hTK kinase domain + cancer drug
    
  • 2f4j, 4twp - hTK kinase domain (mutant) + cancer drug
    
  • 3qrk, 3qri, 3qrj, 2v7a, 2e2b, 2hiw, 4zog, 5hu9, 4yc8, 3pyy, 6npv, 6npu, 6npe, 7cc2, 7dt2, 7w7x, 7w7y - hTK kinase domain + inhibitor
    
  • 1opj, 1opk - mTK kinase domain
    
  • 1fpu, 1m52, 2qoh, 3kf4, 3kfa - mTK kinase domain + inhibitor
    
  • 2z60, 3dk3, 3dk6, 3dk7 - mTK kinase domain (mutant) + inhibitor
    
  • 1iep, 2hzn, 3k5v, 3ms9, 3mss, 3oxz - mTK kinase domain + cancer drug
    
  • 3ik3, 3oy3 - mTK kinase domain (mutant) + cancer drug
    
  • 6hd4, 6hd6 - mTK kinase domain + cancer drug + inhibitor
    

• Abl1 SH2-kinase domain residues 119-531

• • 4xey - hTK SH2-kinase domain
    

• Abl1 SH3-SH2-kinase domain residues 1-531

• • 1opl - hTK SH3-SH2-kinase domain (mutant}
    

• Abl1 F-actin binding domain residues 1007-1130

• • 1zzp - hTK abl F-actin binding domain – NMR
    

• Abl2 SH2 domain residues 165-273

• • 4eih - hTK SH2 domain
    
  • 2ecd - hTK SH2 domain – NMR
    

• Abl2 kinase domain residues 279-546

• • 3gvu - hTK kinase domain + Gleevec
    
  • 3hmi - hTK kinase domain + inhibitor
    
  • 2xyn, 4xli - hTK kinase domain + cancer drug
    

• Abl2 C-terminal residues 1058-1182

• • 2kk1 – hTK C terminal – NMR
    

• Anaplastic lymphoma kinase (Alk) or Alk tyrosine kinae receptor; Domains – Gly-rich 678-986; TG+EGF=like 648-1030; kinase 1093-1411

• • 4tt7, 6cdt - hTK kinase domain
    
  • 3l9p, 3lcs, 3lct, 2yhv, 2yjr, 2yjs, 4fnw, 4fnx, 4anl - hTK kinase domain (mutant)
    
  • 7lrz, 7mzw, 7mzy - hTK Gly-rich domain
    
  • 7nx4 - hTK TG+EGF-like domain
    
  • 7nx3 - hTK TG+EGF-like domain + antibody
    
  • 2xb7, 2xba, 3aox, 5imx, 5kz0, 4ccb, 4ccu, 4cli, 4cmo, 4cmt, 4cmu, 4cnh, 4ctb, 4ctc, 6mx8, 6edl, 6ebw, 6e0r, 7btt, 7jy4, 7jyr, 7jys, 7jyt - hTK kinase domain + inhibitor
    
  • 4dce, 4fob, 4foc, 4fod, 4fny, 4fnz, 4joa, 4mkc, 4z55, 5iug, 5iuh, 5iui, 4cd0, 4clj - hTK kinase domain (mutant) + inhibitor
    
  • 2xp2, 5j7h, 5fto, 5ftq - hTK kinase domain + cancer drug
    
  • 2yfx, 4anq, 4ans, 5aaa, 5aab, 5aac, 5a9u, 5aa8, 5aa9 - hTK kinase domain (mutant) + cancer drug
    
  • [[7n00], 7nwz] - hTK kinase domain (mutant) + AUG-alpha
    
  • 7ls0 - hTK kinase domain/AUG-alpha
    

• Csk tyrosine kinase

• • 3eac - hTK SH2 domain
    
  • 3eaz - hTK SH2 domain (mutant)
    
  • 2rsy - hTK SH2 domain + CBP phosphopeptide - NMR
    
  • 1csk - hTK SH3 domain
    
  • 1jeg - hTK SH3 domain + tyrosine phosphatase peptide - NMR
    
  • 1byg - hTK kinase domain + staurosporine
    
  • 3d7t, 3d7u - hTK kinase domain (mutant) + C-Src
    
  • 1k9a - TK C terminal - rat
    

• Jak tyrosine kinase see Janus kinase

• p55-blk tyrosine kinase

• • 1blj, 1blk - mTK p55-blk SH2 domain – NMR
    

• Src tyrosine kinase or proto-oncogene tyrosine protein kinase (Domains: SH3 85-140; SH2 140-251; kinase 253-535)

• Src tyrosine kinase SH2 domain

• • 3eac - hTK
    
  • 4f59, 3eaz - hTK (mutant)
    
  • 4f5b - hTK (mutant) + phosphotyrosine
    
  • 4f5a - hTK (mutant) + phosphate
    
  • 1o4c - hTK + phosphate
    
  • 1o41, 1o42, 1o43, 1o44, 1o45, 1o46, 1o47, 1o48, 1o49, 1o4a, 1o4b, 1o4d, 1o4e, 1o4f, 1o4g, 1o4h, 1o4i, 1o4j, 1o4k, 1o4l, 1o4m, 1o4n, 1o4o, 1o4p, 1o4q, 1o4r - hTK + inhibitor
    
  • 1hcs, 1hct - hTK + peptide - NMR
    
  • 1a07, 1a08, 1a09, 1a1a, 1a1b, 1a1c, 1a1e - hTK + peptide
    
  • 1f2f - cTK (mutant)
    
  • 1shd - cTK + TRKA receptor
    
  • 1p13 - cTK + peptide
    
  • 1f1w - cTK (mutant) + peptide
    
  • 1spr - RsvTK + phosphate – Rous sarcoma virus
    
  • 2jyq – RsvTK – NMR
    
  • 1kc2, 1sps, 1is0, 1nzl, 1nzv - RsvTK + peptide
    
  • 1sha, 1shb - RsvTK + phosphopeptide
    
  • 1qwe, 1qwf - RsvTK + peptide
    

• Src tyrosine kinase SH3 domain

• • 6c4s – hTK + choline kinase peptide
    
  • 1jeg – mTK + protein-tyrosine phosphatase peptide
    
  • 1srl, 1srm - cTK – NMR
    
  • 3fj5, 4jz3, 4jz4, 6xvo, 6xvn - cTK
    
  • 4le9, 4oml, 4omm, 4omn, 4omo, 4omp, 4omq, 5i11, 4rtu, 4rtx, 7a30, 7a31, 7a32, 7a33, 7a34, 7a35, 7a36, 7a37, 7a38, 7a39, 7a3a, 7a3b, 7a3c, 7a3d, 7a3e, 7ner, 7nes, 7net - cTK (mutant)
    
  • 6xx3, 6xx2, 6xx5, 6xx4, 6xx5, 6xx2 - cTK (mutant) + ion
    
  • 4hxj, 1prl, 4qt7, 4rty, 4rtz - cTK + peptide
    
  • 1prm, 1rlp, 1rlq, 1nlo, 1nlp - cTK + peptide - NMR
    
  • 4hvu, 4hvv, 4hvw, 4rtv, 4rtw, 5ob2, 5ob1, 5ob0, 5oav - cTK (mutant) + peptide
    
  • 4y92 - TK (mutant) - Avian sarcoma virus
    

• Src tyrosine kinase kinase domain residues 253-535

• • 1yo6 - hTK
    
  • 1yoj - hTK (mutant)
    
  • 2bdf, 2bdj, 6e6e, 6ate, 7ng7 – hTK + inhibitor
    
  • 1yol, 1yom – hTK (mutant) + inhibitor
    
  • 1byg – hTK + staurosporine
    
  • 4mxo – hTK + cancer drug
    
  • 4mxx, 4mxy, 4mxz – hTK (mutant) + cancer drug
    
  • 3of0, 2qi8 - cTK (mutant)
    
  • 3d7t, 3d7u – cTK + Csk
    
  • 3dqw, 3dqx - cTK (mutant) + ATP
    
  • 3tz7, 3tz8, 3tz9, 4dgg – cTK (mutant) + pyrazolin derivative
    
  • 4fic, 3uqg, 3uqf, 3u51, 3u4w, 4agw, 3qlg, 3qlf, 3g6g, 3el8, 3f6x, 2hwo, 2hwp, 2oiq, 3en4, 3en5, 3en6, 3en7, 3el7, 5bmm, 5j5s, 4ybj, 4ybk, 5xp7, 7ah3, 7d57, 7d5o – cTK + inhibitor
    
  • 7wf5 – cTK + cancer drug
    
  • 4lgg, 4lgh, 3svv, 3oez, 3lok, 3g5d, 3f3w, 3f3v, 3geq, 3g6h, 3f3t, 3f3u, 2qlq, 2qq7, 4lgg, 4lgh, 4mcv, 4o2p, 5teh, 5t0p, 5sys, 5swh, 6hve, 6hvf – cTK (mutant) + inhibitor
    
  • 4u5j – cTK (mutant) + cancer drug
    

• Src tyrosine kinase C terminal domain

• • 1k9a – rTK
    

• Src tyrosine kinase SH2+SH3+kinase domains residues 85-535

• • 1ksw – hTK (mutant)+ ADP derivative
    
  • 1y57 – hTK + inhibitor
    
  • 4k11 – hTK (mutant) + inhibitor
    
  • 6f3f – mTK + ADP
    

• Src tyrosine kinase SH2+SH3+kinase+C terminal domains

• • 1fmk – hTK
    
  • 2src – hTK + AMPPNP
    
  • 2ptk – cTK
    

• Src tyrosine kinase N terminal+SH2+SH3+kinase domains

• • 2h8h – hTK + inhibitor
    

• Lymphocyte-specific tyrosine kinase Lck (Domains: SH3 58-118; SH2 122-225; kinase 230-500)

• • 1kik, 1h92 - hTK Lck SH3 domain – NMR
    
  • 2iim - hTK Lck SH3 domain
    
  • 4d8k, 1x27 - hTK Lck SH3-SH2 domain
    
  • 3lck - hTK Lck kinase domain
    

• Lck complex

• • 1lcj, 1lkk, 1lkl - hTK Lck SH2 domain (mutant) + phosphopeptide
    
  • 1cwd, 1cwe, 1ijr - hTK Lck SH2 domain + phosphopeptide
    
  • 1bhf - hTK Lck SH2 domain + peptide inhibitor
    
  • 1fbz - hTK Lck SH2 domain + inhibitor
    
  • 1bhh - hTK Lck SH2 domain + T-lymphocyte-specific TK
    
  • 5mtm, 5mtn - hTK Lck SH2 domain + monobody
    
  • 1lck - hTK Lck SH3-SH2 domain (mutant) + phosphopeptide
    
  • 1x27 - hTK Lck SH3-SH2 domain + peptide
    
  • 1qpj - hTK Lck kinase domain + staurosporin
    
  • 2of2, 2of4, 2ofu, 2ofv, 2og8, 3b2w, 3bym, 3bys, 3byu, 2zm1, 2zm4, 3byo, 2zyb, 3ac1, 3ac2, 3ac3, 3ac4, 3ac5, 3ac8, 3acj, 3ack, 3kmm, 3ad4, 3ad5, 3ad6, 1qpc, 1qpd, 1qpe, 6pdj - hTK Lck kinase domain + inhibitor
    
  • 3mpm - hTK Lck kinase domain (mutant) + inhibitor
    
  • 4c3f - hTK Lck kinase domain (mutant) + chemotype
    
  • 2pl0 - hTK Lck kinase domain + anti-cancer drug
    
  • 3kxz - hTK Lck kinase domain + probe molecule
    
  • 1q68 - hTK Lck residues 6-34 (mutant) + CD4 peptide – NMR
    
  • 1q69 - hTK Lck residues 6-34 (mutant) + CD8 – NMR
    

• Syk - spleen tyrosine kinase

• • 1xba, 4xg2 – hSyk kinase domain residues 337-635

• Syk complex

• • 1xbb - hSyk kinase domain + Gleevec
    
  • 1xbc - hSyk kinase domain + staurosporine
    
  • 3emg, 3fqe, 3fqh, 3fqs, 3srv, 4dfl, 4dfn, 3vf8, 3vf9, 3tub, 3tuc, 3tud, 4f4p, 4fyn, 4fyo, 4fz6, 4fz7, 4gfg, 4i0r, 4i0s, 4i0t, 4puz, 4pv0, 4rx7, 4rx8, 4rx9, 5lma, 5lmb, 5ghv, 4wnm, 4xg3, 4xg4, 4xg6, 4xg7, 4xg8, 4xg9, 4rss, 4yjv, 5c26, 5c27, 4yjo, 4yjp, 4yjq, 4yjr, 4yjs, 4yjt, 4yju, 5tr6, 5tt7, 5tiu, 5t68, 5y5t, 5y5u, 4gfg, 6hm6, 6hm7, 6vov, 6zc0, 6zcp, 6zcq, 6zcr, 6zcs, 6zcu, 6zcx, 6zcy - hSyk kinase domain + inhibitor
    
  • 4px6, 5cxh, 5cxz, 5cy3 - hSyk kinase domain (mutant) + inhibitor
    
  • 1csy, 1csz - hSyk SH2 domain + phosphopeptide – NMR
    
  • 4fl1, 4fl2 - hSyk kinase domain + ANP
    
  • 4fl3 - hSyk kinase domain (mutant) + ANP
    
  • 7q63, 7sa7 – hSyk tandem SH2 domain
    
  • 1a81, 7q5t, 7q5u, 7q5w – hSyk tandem SH2 domain + T-cell surface peptide
    

• Itk/Tsk tyrosine kinase or interleukin-2 tyrosine kinase; domains – SH2 236-344; SH3 160-236; kinase 357-620

• • 2etz, 2eu0 – hTK Itk SH2 domain + phosphopeptide – NMR
    
  • 2yuq, 2lmj – hTK Itk SH3 domain – NMR
    
  • 1sm2, 1snu, 1snx – hTK Itk kinase domain
    
  • 3miy – hTK Itk kinase domain + cancer drug
    
  • 3v5j, 3v5l, 3v8t, 3v8w – hTK Itk kinase domain + inhibitor
    
  • 3mj1, 3mj2, 3qgw, 3qgy, 4hct, 4hcu, 4hcv, 4kio – hTK Itk kinase domain (mutant) + inhibitor
    
  • 3t9t – hTK Itk kinase domain (mutant) + arthritis drug
    
  • 2e6i – hTK Itk BTK motif – NMR
    
  • 4l7s, 4m0y, 4m0z, 4m12, 4m13, 4m14, 4m15, 4mf0, 4mf1, 3v5j, 3v5l, 3v8t, 3v8w - hTK Itk kinase domain + inhibitor
    
  • 4pp9, 4ppa, 4ppb, 4ppc, 4pqn, 4qd6, 4rfm, 4kio - hTK Itk kinase domain (mutant) + inhibitor
    
  • 1lui, 1luk, 1lum, 1lun – mTK Itk SH2 domain – NMR
    
  • 3s9k – mTK Itk SH2 domain
    
  • 1awj, 2rn8, 2rna – mTK Itk SH3 domain – NMR
    
  • 2k79, 2k7a – mTK Itk SH2+SH3 domains – NMR
    

• Zap-70 tyrosine kinase (Domains: SH2 1-259; kinase 327-606

• • 4k2r – hTK Zap-70
    
  • 2ozo - hTK Zap-70 (mutant)
    
  • 1m61 - hTK Zap-70 SH2 domain

• Zap-70 complex

• • 2oq1, 4xz1 - hTK Zap-70 SH2 domain + peptide
    
  • 4xz0 - hTK Zap-70 SH2 domain + inhibitor
    
  • 1u59 - hTK Zap-70 kinase domain + staurosporine

• Pyk2 tyrosine kinase or or protein-tyrosine kinase 2-β (Domains: kinase 414-692; FAT 861-1009)

• • 3cc6, 3fzo - hTK Pyk2 kinase domain
    
  • 3gm2 - hTK Pyk2 FAT domain
    
  • 3gm3 - hTK Pyk2 FAT domain (mutant)
    
  • 4eku – hTK Pyk2 FERM domain
    
  • 2lk4 - hTK Pyk2 FAT domain – NMR
    

• Pyk2 complex

• • 3fzp - hTK Pyk2 kinase domain + ATPγS
    
  • 3fzr, 3fzs, 3fzt, 3h3c, 3et7, 5to8, 5tob, 4h1j, 4h1m - hTK Pyk2 kinase domain + inhibitor
    
  • 3gm1, 4r32 - hTK Pyk2 FAT domain + paxillin peptide
    
  • 4xek, 4xev, 4xef - hTK Pyk2 FAT domain + leupaxin peptide
    
  • 4h1j - hFAK2 kinase domain + pyrazole inhibitor
    
  • 3h3c - hFAK2 kinase domain + pyrimidine inhibitor
    
  • 4h1m - hFAK2 kinase domain + indole inhibitor
    
  • 3u3f – hFAK2 FAT domain (mutant) + paxillin LD2 motif
    

• CapAB tyrosine kinase

• • 3bfv - SaTK CapA1/CapB2 – Staphylococcus aureus
    
  • 2ved - SaTK CapA1/CapB2 + Mg + ADP

• Fer tyrosine kinase

• • 2kk6 - hTK Fer SH2 domain – NMR
    
  • 6kc4 - hTK Fer SH2 domain + phosphopeptide
    

• Ptk6 tyrosine kinase or breast tumor kinase Brk

• • 1rja - hTK Ptk6 SH2 domain – NMR
    
  • 2kgt - hTK Ptk6 SH3 domain – NMR
    
  • 5d7v, 6cz2 - hTK Ptk6 kinase domain
    
  • 5da3, 6cz3, 6cz4 - hTK Ptk6 kinase domain + inhibitor
    
  • 5h2u - hTK Ptk6 kinase domain (mutant) + cancer drug
    

• PtkA tyrosine kinase

• • 6f2x - TK PtkA – Mycobacterium tuberculosis - NMR
    

• Lyn tyrosine kinase (Domains: SH3 39-101; SH2 115-229; kinase 239-512)

• • 4tzi - hTK Lyn SH2 domain
    
  • 6nmw - hTK Lyn SH3 domain
    
  • 1w1f - hTK Lyn SH3 domain – NMR
    
  • 1wa7 - hTK Lyn SH3 domain + peptide – NMR
    
  • 3a4o - hTK Lyn residues 233-512 + staurosporine
    
  • 5xy1 - hTK Lyn kinase domain + inhibitor
    
  • 2zv7 - mTK Lyn kinase domain
    
  • 2zv8 - mTK Lyn kinase domain + AMPPNP
    
  • 2zv9 - mTK Lyn kinase domain + PP2
    
  • 2zva - mTK Lyn kinase domain + cancer drug
    

• Txk tyrosine kinase

• • 2dm0 - hTK Txk SH2 domain – NMR
    

• Yes tyrosine kinase

• • 2hda - hTK Yes SH3 domain
    
  • 5mtj - hTK Yes SH2 domain + monobody
    

• Tec tyrosine kinase

• • 2lul - hTK Tec PH domain - NMR
    
  • 1gl5 - hTK Tec SH3 domain - NMR
    

• Fes/Fps tyrosine kinase

• • 1wqu, 2dcr - hTK Fes SH2 domain - NMR
    
  • 3bkb - hTK Fes SH2+kinase domain - NMR
    
  • 4dyl - hTK Fes F-Bar domain
    
  • 3cbl - hTK Fes SH2+kinase domain + peptide
    
  • 3cd3 - hTK Fes SH2+kinase domain + peptide + staurosporine
    
  • 4e93, 6jmf - hTK TFes + inhibitor
    

• Etk tyrosine kinase

• • 3cio - EcTK Etk kinase domain – Escherichia coli
    

• Wzc tyrosine kinase

• • 3la6 - EcTK Wzc kinase domain
    
  • 7ni2, 7nib - EcTK Wzc – Cryo EM
    
  • 7dhd - VvTK Wzc – Vibrio vulnificus
    
  • 7dhe, 7dhf - VvTK Wzc + inhibitor
    

• Ros tyrosine kinase

• • 3zbf - hTK Ros kinase domain + cancer drug
    
  • 4uxl - hTK Ros kinase domain + inhibitor
    

• Non-receptor Tyk2 tyrosine kinase (Domains: SH2+FERM 23-540; pseudokinase 541-880; kinase 880-1170)

• • 5f20, 5f1z, 6ova - hTK Tyk2 kinase domain + inhibitor
    
  • 3lxn, 3lxp, 3nyx, 3nz0, 4e1z, 4e20, 4gfo, 4gih, 4gii, 4gj2, 4gj3, 4py1, 5wal, 5wev, 6dbk, 6dbm - hTK Tyk2 kinase domain (mutant) + inhibitor
    
  • 6aam, 6x8g, 6x8f - hTK Tyk2 kinase domain (mutant) + drug
    
  • 4gvj - hTK Tyk2 kinase domain (mutant) + ADP
    
  • 4oli - hTK Tyk2 pseudokinase + kinase domains
    
  • 3zon, 5c01, 5c03 - hTK Tyk2 pseudokinase domain
    
  • 4wov, 5tkd, 6nzr, 6nzq, 6nzp, 6nzh, 6nzf, 6nze, 6nsl, 7ax4, 7k7o, 7k7q - hTK Tyk2 pseudokinase domain + inhibitor
    
  • 4po6 - hTK Tyk2 SH2+FERM domains + IFNAR1 peptide
    

• Hck tyrosine kinase Domains: SH3 81-137; SH2 119-224; SH1 or kinase+C-terminal 225-525;

• • 3hck - hTK SH2 domain - NMR
    
  • 1bu1 - hTK SH3 domain
    
  • 4hck, 5hck - hTK SH3 domain - NMR
    
  • 2oj2, 2oi3 - hTK SH3 domain + peptide - NMR
    
  • 3rbb, 3rea, 3reb - hTK SH3 domain (mutant) + HIV NEF
    
  • 5nuh - hTK SH3 domain + SIV NEF
    
  • 4orz - hTK SH3 domain (mutant) + HIV NEF + single domain antibody
    
  • 3nhn - hTK SH3-SH2-linker domain
    
  • 4u5w - hTK Hck SH3-SH2 domains + NEF
    
  • 2c0i, 2c0o, 2c0t - hTK SH3-SH2-SH1 domain + inhibitor
    
  • 5h0b, 5h0e, 5h0g, 5h0h - hTK SH3-SH2-SH1 domain (mutant) + inhibitor
    
  • 2hk5, 5zj6 - hTK kinase domain + inhibitor
    
  • 1qcf, 3vrz, 3vs0, 3vs3, 3vs4, 3vs5, 3vs6, 3vs7 - hTK SH3-SH2-kinase-C-terminal domain + inhibitor
    
  • 3vry, 3vs1, 3vs2 - hTK SH3-SH2-kinase-C-terminal domain (mutant) + inhibitor
    
  • 1ad5 - hTK SH3-SH2-kinase-C-terminal domain + AMPPNP
    
  • 2hck - hTK SH3-SH2-kinase-C-terminal domain + quercetin
    
  • 4lud, 4lue - hTK SH2+SH3+kinase+C-terrminal domain (mutant) + fluorescent compound
    

• Ack1 tyrosine kinase or activated cdc42 kinase 1

• • 1u46, 4hzr - hTK Ack1 kinase domain
    
  • 4hzs - hTK Ack1 kinase+SH3 domains
    
  • 1u4d, 3eqp, 3eqr, 4ewh, 4id7, 5zxb - hTK Ack1 kinase domain + inhibitor
    

• RECEPTOR TYROSINE KINASES - RTK

• Bruton’s tyrosine kinase (Domains: PH 1-170; SH3 216-273; SH2 273-378; kinase 378-659)

• • 2z0p - hTK Btk PH domain
    
  • 1btk – hTK Btk PH domain (mutant)
    
  • 3p08, 1k2p - hTK Btk kinase domain
    
  • 1aww, 1awx, 1qly - hTK Btk SH3 domain – NMR
    
  • 2ge9 - hTK Btk SH2 domain – NMR
    
  • 4xi2 - hTK Btk SH3-SH2-kinase domain
    
  • 4y95 - bTK Btk kinase domain (mutant) - bovine
    
  • 4y93 - bTK Btk PH+kinase domains (mutant)
    

• Btk complex

• • 1b55 - hTK Btk PH domain + inositol-tetrakisphosphate
    
  • 1bwn - hTK Btk PH domain (mutant) + inositol-tetrakisphosphate
    
  • 6yyf, 6yyg, 6yyk - hTK Btk PH domain (mutant) + inhibitor
    
  • 3gen, 3ocs, 3pix, 3piy, 3piz, 3pj1, 3pj2, 3pj3, 4nwm, 4yhf, 5jrs, 5fbo, 5fbn, 4rx5, 5bpy, 5bq0, 5vgo, 5u9d, 5t18, 5p9m, 5p9l, 5p9m, 5p9l, 5p9f, 5p9g, 5p9h, 5p9i, 5p9j, 5p9k, 5vfi, 4z3v, 4zly, 4zlz, 5zz4, 6aua, 6aub, 5j87, 5xyz, 6bik, 6bke, 6bkh, 6bkw, 6bln, 6di0, 6di1, 6di3, 6di5, 6di9, 6e4f, 6e9p, 5kup, 6tfp, 6s90, 6o8i, 6nzm, 6nfi, 6nfh, 6n9p, 6w07, 6w06, 6vxq, 6x3n, 6x3o, 6x3p, 6xe4, 7kxl, 7kxm, 7kxn, 7kxo, 7kxp, 7kxq, 7lty, 7ltz, 7n4q, 7n4r, 7n4s, 7n5o, 7n5r, 7n5x, 7n5y, 7r60, 7r61 - hTK Btk kinase domain + inhibitor
    
  • 3k54, 3t9t, 4ot5, 4ot6, 4otq, 4otr, 4otf, 4rfy, 4rfz, 4rg0, 6ep9, 6hrt, 6hrp - hTK Btk kinase domain (mutant) + inhibitor
    
  • 6w7o, 6w8i - hTK Btk kinase domain + cIAP + inhibitor
    
  • 5vgo - hTK Btk kinase domain + cancer drug
    
  • 3oct - hTK Btk kinase domain (mutant) + cancer drug
    
  • 6omu - hTK Btk kinase domain + MS drug
    
  • 6j6m - hTK Btk kinase domain + MCL drug
    
  • 4y94 - bTK Btk kinase domain + inhibitor
    
  • 6mny - mTK Btk kinase domain + inhibitor
    

• c-FMS tyrosine kinase or macrophage colony-stimulating factor 1 receptor see Colony-stimulating factor receptor

• Kit tyrosine kinase or mast/stem cell growth factor receptor Kit; Domains – extracellular 1-519; kinase 547-693, 754-935

• • 2ec8 - hTK Kit extracellular domain
    
  • 3g0e, 3g0f - hTK Kit kinase domain (mutant) + cancer drug
    
  • 2e9w - hTK Kit extracellular domain + stem cell factor
    
  • 1t45, 4pgz - hTK Kit kinase domain
    
  • 1t46, 4u0i, 6mob, 6kla - hTK Kit kinase domain + cancer drug
    
  • 6gqj, 6gql, 6gqm, 6gqk - hTK Kit kinase domain (mutant) + cancer drug
    
  • 6itv, 6itt, 6xv9, 6xva, 6xvb, 7khg, 7khj, 7khk - hTK Kit kinase domain + inhibitor
    
  • 4hvs, 6hh1 - hTK Kit kinase domain (mutant) + inhibitor
    
  • 2o26 - hTK Kit residues 25-314 + Kit ligand
    
  • 4k94, 4k9e - hTK Kit residues 308-518 + antibody
    

• Mer tyrosine kinase (Domains: FN3 373-483; kinase 570-864)

• • 2dbj - hTK Mer FN3 domain – NMR
    
  • 2p0c - hTK Mer kinase domain

• Mer complex

• • 7ab0 - hTK Mer kinase domain
    
  • 3brb - hTK Mer kinase domain + ADP
    
  • 2p0c - hTK Mer kinase domain + ANP
    
  • 3bpr, 3tcp, 4m3q, 4mh7, 4mha, 5u6c, 5tc0, 5k0k, 5k0x, 5td2, 6mep, 7m5z - hTK Mer kinase domain + inhibitor
    
  • 7ab2, 7aax, 7aaz - hTK Mer kinase domain (mutant) + inhibitor
    
  • 7ab1 - hTK Mer kinase domain + anti-cancer drug
    
  • 7aay - hTK Mer kinase domain (mutant) + anti-cancer drug
    

• Bone marrow tyrosine kinase; Domains – kinase 411-675

• • 2ekx - hTK Bmx SH2 domain – NMR
    
  • 2ys2 - hTK Bmx Btk motif – NMR
    

• Bone marrow tyrosine kinase complex

• • 3sxr - hTK Bmx kinase domain (mutant) + anti-cancer drug
    
  • 3sxs, 6i99 - hTK Bmx kinase domain (mutant) + inhibitor
    

• ErbB tyrosine kinase see Epidermal Growth Factor Receptor

• MuSK tyrosine kinase

• • 3hkl - rTK MuSK Fz-Crd domain
    
  • 1luf, 2iep - rTK MuSK cytoplasmic domain
    

• Sgk223 tyrosine kinase or sugen kinase

• • 5ve6 - hTK
    

• Matk tyrosine kinase or megakaryocyte-associated tyrosine-protein kinase

• • 3us4 - hTK Matk SH2 domain
    
  • 1x6g - hTK Matk SH3 domain - NMR
    

• Flt3 tyrosine kinase

• • 1rjb - hTK Flt3 kinase domain
    
  • 4rt7, 6il3, 5x02 - hTK Flt3 kinase domain + inhibitor
    
  • 6jqr - hTK Flt3 kinase domain + leukemia drug<br /
  • 4xuf - hTK Flt3 kinase domain (mutant) + leukemia drug
    
  • 3qs7, 3qs9 - hTK Flt3 kinase domain + SL cytokine<br /

• Tie2 tyrosine kinase

• • 1fvr - hTK Tie2 kinase domain
    

• Ret tyrosine kinase or proto-oncogene tyrosine protein kinase receptor Ret

• • 6nja - hTK Ret kinase domain
    
  • 6fek - hTK Ret kinase domain (mutant)
    
  • 5amn, 6vhg, 7run - hTK Ret kinase domain + inhibitor
    
  • 6i83, 6i82 - hTK Ret kinase domain (mutant) + inhibitor
    
  • 6nec, 6ne7, 7ju5

- hTK Ret kinase domain + cancer drug

• • 4ux8 - hTK Ret extracellular domain + GFR alpha 1
    

• DDR1 and DDR2 tyrosine kinase receptors see Epithelial discoidin domain-containing receptor
• c-Met tyrosine kinase see Hepatocyte growth factor receptor

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