1m10
From Proteopedia
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===Crystal structure of the complex of Glycoprotein Ib alpha and the von Willebrand Factor A1 Domain=== | ===Crystal structure of the complex of Glycoprotein Ib alpha and the von Willebrand Factor A1 Domain=== | ||
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==See Also== | ==See Also== | ||
*[[Platelet-receptor glycoprotein Ib alpha|Platelet-receptor glycoprotein Ib alpha]] | *[[Platelet-receptor glycoprotein Ib alpha|Platelet-receptor glycoprotein Ib alpha]] | ||
| - | *[[User:Wayne Decatur/Templates|User:Wayne Decatur/Templates]] | ||
*[[User:Wayne Decatur/UNH CME Workshop March 11 2011|User:Wayne Decatur/UNH CME Workshop March 11 2011]] | *[[User:Wayne Decatur/UNH CME Workshop March 11 2011|User:Wayne Decatur/UNH CME Workshop March 11 2011]] | ||
*[[User:Wayne Decatur/UNH Seminar Feb 1st 2011|User:Wayne Decatur/UNH Seminar Feb 1st 2011]] | *[[User:Wayne Decatur/UNH Seminar Feb 1st 2011|User:Wayne Decatur/UNH Seminar Feb 1st 2011]] | ||
Revision as of 18:24, 25 July 2012
Contents |
Crystal structure of the complex of Glycoprotein Ib alpha and the von Willebrand Factor A1 Domain
Transient interactions of platelet-receptor glycoprotein Ibalpha (GpIbalpha) and the plasma protein von Willebrand factor (VWF) reduce platelet velocity at sites of vascular damage and play a role in haemostasis and thrombosis. Here we present structures of the GpIbalpha amino-terminal domain and its complex with the VWF domain A1. In the complex, GpIbalpha wraps around one side of A1, providing two contact areas bridged by an area of solvated charge interaction. The structures explain the effects of gain-of-function mutations related to bleeding disorders and provide a model for shear-induced activation. These detailed insights into the initial interactions in platelet adhesion are relevant to the development of antithrombotic drugs.
Structures of glycoprotein Ibalpha and its complex with von Willebrand factor A1 domain., Huizinga EG, Tsuji S, Romijn RA, Schiphorst ME, de Groot PG, Sixma JJ, Gros P, Science. 2002 Aug 16;297(5584):1176-9. PMID:12183630
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
1m10 is a 2 chain structure of Platelet-receptor glycoprotein Ib alpha with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
- Platelet-receptor glycoprotein Ib alpha
- User:Wayne Decatur/UNH CME Workshop March 11 2011
- User:Wayne Decatur/UNH Seminar Feb 1st 2011
Reference
- Huizinga EG, Tsuji S, Romijn RA, Schiphorst ME, de Groot PG, Sixma JJ, Gros P. Structures of glycoprotein Ibalpha and its complex with von Willebrand factor A1 domain. Science. 2002 Aug 16;297(5584):1176-9. PMID:12183630 doi:10.1126/science.107355
