This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Troponin
From Proteopedia
(Difference between revisions)
| Line 26: | Line 26: | ||
**[[1lxf]], [[1mxl]] - hTnC N-terminal+hTnI fragment<br /> | **[[1lxf]], [[1mxl]] - hTnC N-terminal+hTnI fragment<br /> | ||
**[[2kgb]] – hTnC (mutant) regulatory domain+TnI<br /> | **[[2kgb]] – hTnC (mutant) regulatory domain+TnI<br /> | ||
| - | **[[1sbj]] – cTnC C-terminal+cTnI N-terminal+Mg | + | **[[2mzp]] - hTnC regulatory domain+TnI switch region (mutant) <br /> |
| + | **[[1sbj]] – cTnC C-terminal+cTnI N-terminal+Mg - NMR<br /> | ||
**[[1scv]], [[1fi5]], [[1blq]] - cTnC C-terminal+cTnI N-terminal – NMR<br /> | **[[1scv]], [[1fi5]], [[1blq]] - cTnC C-terminal+cTnI N-terminal – NMR<br /> | ||
**[[1npq]] - cTnC (mutant) N-terminal+cTnI fragment+rhodamine<br /> | **[[1npq]] - cTnC (mutant) N-terminal+cTnI fragment+rhodamine<br /> | ||
Revision as of 06:57, 22 June 2015
Troponin (Tn) is a regulatory protein in muscle contraction. It contains 3 subunits:
- TnC causes conformational change in TnI when it binds to calcium ions. For more details on TnC see Role of Troponin C in decreased muscle sensitivity to calcium.
- TnT binds to tropomyosin.
- TnI binds to actin which is found in thin muscle filaments.
See additional details in Human Cardiac Troponin C.
3D Structures of Troponin
Updated on 22-June-2015
