SUMO

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Line 32: Line 32:
**[[1u4a]] – hSUMO-3 (mutant) – NMR – human<br />
**[[1u4a]] – hSUMO-3 (mutant) – NMR – human<br />
**[[1a5r]] - hSUMO-1 - NMR<br />
**[[1a5r]] - hSUMO-1 - NMR<br />
 +
**[[2n1v]], [[2mw5]] – hSUMO-1 - NMR<br />
**[[1wm2]], [[1wm3]], [[2awt]], [[4bkg]], [[4npn]] – hSUMO-2<br />
**[[1wm2]], [[1wm3]], [[2awt]], [[4bkg]], [[4npn]] – hSUMO-2<br />
 +
**[[2n1w]] – hSUMO-2 - NMR<br />
* SUMO+ubiquitin-like SUMO-conjugating enzyme
* SUMO+ubiquitin-like SUMO-conjugating enzyme
Line 49: Line 51:
**[[2iyd]], [[2ckh]], [[3zo5]] - hSUMO-2+SEPN1<br />
**[[2iyd]], [[2ckh]], [[3zo5]] - hSUMO-2+SEPN1<br />
**[[1tgz]] - hSUMO-1+SEPN2<br />
**[[1tgz]] - hSUMO-1+SEPN2<br />
 +
**[[5aek]] - hSUMO-1 (mutant) +SEPN2 (mutant)<br />
**[[2io3]] - pre-hSUMO-2+SEPN2 (mutant)+RAN GTPase-activating enzyme (mutant)<br />
**[[2io3]] - pre-hSUMO-2+SEPN2 (mutant)+RAN GTPase-activating enzyme (mutant)<br />
**[[2iy0]] - hSUMO-1+SEPN1 (mutant)+RAN GTPase-activating enzyme <br />
**[[2iy0]] - hSUMO-1+SEPN1 (mutant)+RAN GTPase-activating enzyme <br />
Line 55: Line 58:
**[[1z5s]] - hSUMO-1+E2+ RAN GTPase-activating enzyme<br />
**[[1z5s]] - hSUMO-1+E2+ RAN GTPase-activating enzyme<br />
 +
**[[5d2m]] - hSUMO-2+E2+ RAN GTPase-activating enzyme + ZNF451<br />
**[[2bf8]] - SUMO-1+E2 - bovine<br />
**[[2bf8]] - SUMO-1+E2 - bovine<br />
Line 78: Line 82:
**[[4wjp]], [[4wjq]] – hSUMO-1 (mutant) + DAXX<br />
**[[4wjp]], [[4wjq]] – hSUMO-1 (mutant) + DAXX<br />
**[[3rzw]] – hSUMO-1 (mutant) + monobody<br />
**[[3rzw]] – hSUMO-1 (mutant) + monobody<br />
 +
**[[2n1a]] – hSUMO-1 + CREB-binding protein - NMR<br />
 +
**[[2n9e]] – hSUMO-2 + RAP80 - NMR<br />
**[[2mp2]] – hSUMO-3 + E3 ubiquitin protein ligase<br />
**[[2mp2]] – hSUMO-3 + E3 ubiquitin protein ligase<br />

Revision as of 09:19, 5 September 2016

Human SUMO-1 (yellow) complex with SUMO-activating enzyme subunit 1 (grey), SUMO-activating enzyme subunit 2 (green), adenosine derivative and Zn+2 ion (grey) (PDB code 3kyc)

Drag the structure with the mouse to rotate

For better understanding of the difference between these two conformations you can see this morph (generated by using POLYVIEW-3D: http://polyview.cchmc.org/polyview3d.html; reload/refresh this page to restart this movie). Of note, in contrast to the previous figure, the same domains of these two structures (3kyc and 3kyd) are colored in the same colors (SUMO1 in yellow, SAE1 colored in blue and other domains in darkviolet). The catalytic Cys173 is shown in the spacefill representation and colored green, AMSN (or AVSN) are shown in the spacefill representation and colored in CPK colors.

3D Structures of SUMO

Updated on 05-September-2016

Reference

  • Olsen SK, Capili AD, Lu X, Tan DS, Lima CD. Active site remodelling accompanies thioester bond formation in the SUMO E1. Nature. 2010 Feb 18;463(7283):906-12. PMID:20164921 doi:10.1038/nature08765

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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