SUMO

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Line 31: Line 31:
**[[2k8h]] – SUMO – NMR – ''Trypanosoma brucei''<br />
**[[2k8h]] – SUMO – NMR – ''Trypanosoma brucei''<br />
**[[1u4a]] – hSUMO-3 (mutant) – NMR – human<br />
**[[1u4a]] – hSUMO-3 (mutant) – NMR – human<br />
-
**[[1a5r]] - hSUMO-1 - NMR<br />
+
**[[2n1v]], [[2mw5]], [[5ghd]], [[5b7r]], [[1a5r]] – hSUMO-1 - NMR<br />
-
**[[2n1v]], [[2mw5]] – hSUMO-1 - NMR<br />
+
**[[1wm2]], [[1wm3]], [[2awt]], [[4bkg]], [[4npn]] – hSUMO-2<br />
**[[1wm2]], [[1wm3]], [[2awt]], [[4bkg]], [[4npn]] – hSUMO-2<br />
-
**[[2n1w]] – hSUMO-2 - NMR<br />
+
**[[2n1w]], [[5ghb]], [[5ghc]] – hSUMO-2 - NMR<br />
 +
**[[1u4a]] – hSUMO-3 (mutant) – NMR <br />
* SUMO+ubiquitin-like SUMO-conjugating enzyme
* SUMO+ubiquitin-like SUMO-conjugating enzyme
Line 73: Line 73:
**[[2asq]] – hSUMO-1+SUMO-binding motif in PIASX<br />
**[[2asq]] – hSUMO-1+SUMO-binding motif in PIASX<br />
-
**[[3kyc]], [[3kyd]] – hSUMO+SUMO-activating enzyme <br />
+
**[[3kyc]], [[3kyd]] – hSUMO-1 +SUMO-activating enzyme <br />
-
**[[2rpq]] – hSUMO-3+activating transcription factor <br />
+
**[[5eql]] – hSUMO-1 + SUMO-adhiron-S2D5<br />
**[[1wyw]] - hSUMO-1+thymine DNA glycosylate<br />
**[[1wyw]] - hSUMO-1+thymine DNA glycosylate<br />
-
**[[2d07]] - hSUMO-3+thymine DNA glycosylate<br />
 
**[[2kqs]] - hSUMO-1+death domain-associated protein 6 fragment<br />
**[[2kqs]] - hSUMO-1+death domain-associated protein 6 fragment<br />
**[[2las]] – hSUMO-1 + M-IR2 peptide<br />
**[[2las]] – hSUMO-1 + M-IR2 peptide<br />
Line 84: Line 83:
**[[2n1a]] – hSUMO-1 + CREB-binding protein - NMR<br />
**[[2n1a]] – hSUMO-1 + CREB-binding protein - NMR<br />
**[[2n9e]] – hSUMO-2 + RAP80 - NMR<br />
**[[2n9e]] – hSUMO-2 + RAP80 - NMR<br />
 +
**[[5eql]], [[5elu]] – hSUMO-2 + SUMO-adhiron-S2D5<br />
 +
**[[5tvq]] – hSUMO-2 + tyrosyl-DNA phosphodiesterase<br />
 +
**[[5tvp]] – hSUMO-2 + tyrosyl-DNA phosphodiesterase + DNA<br />
**[[2mp2]] – hSUMO-3 + E3 ubiquitin protein ligase<br />
**[[2mp2]] – hSUMO-3 + E3 ubiquitin protein ligase<br />
 +
**[[2rpq]] – hSUMO-3+activating transcription factor <br />
 +
**[[2d07]] - hSUMO-3+thymine DNA glycosylate<br />
 +
**[[5jp1]] – SUMO + xanthomonas outer protein D - tomato<br />
 +
}}
}}

Revision as of 10:31, 7 November 2017

Human SUMO-1 (yellow) complex with SUMO-activating enzyme subunit 1 (grey), SUMO-activating enzyme subunit 2 (green), adenosine derivative and Zn+2 ion (grey) (PDB code 3kyc)

Drag the structure with the mouse to rotate

For better understanding of the difference between these two conformations you can see this morph (generated by using POLYVIEW-3D: http://polyview.cchmc.org/polyview3d.html; reload/refresh this page to restart this movie). Of note, in contrast to the previous figure, the same domains of these two structures (3kyc and 3kyd) are colored in the same colors (SUMO1 in yellow, SAE1 colored in blue and other domains in darkviolet). The catalytic Cys173 is shown in the spacefill representation and colored green, AMSN (or AVSN) are shown in the spacefill representation and colored in CPK colors.

3D Structures of SUMO

Updated on 07-November-2017

Reference

  1. ↑ Sarge KD, Park-Sarge OK. Sumoylation and human disease pathogenesis. Trends Biochem Sci. 2009 Apr;34(4):200-5. doi: 10.1016/j.tibs.2009.01.004. Epub, 2009 Mar 11. PMID:19282183 doi:http://dx.doi.org/10.1016/j.tibs.2009.01.004
  2. ↑ Olsen SK, Capili AD, Lu X, Tan DS, Lima CD. Active site remodelling accompanies thioester bond formation in the SUMO E1. Nature. 2010 Feb 18;463(7283):906-12. PMID:20164921 doi:10.1038/nature08765

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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