SUMO
From Proteopedia
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For better understanding of the difference between these two conformations you can see this [[Morphs|morph]] (generated by using [http://polyview.cchmc.org/polyview3d.html POLYVIEW-3D: http://polyview.cchmc.org/polyview3d.html]; reload/refresh this page to restart this movie). Of note, in contrast to the previous figure, the same domains of these two structures ([[3kyc]] and [[3kyd]]) are colored in the same colors (<font color='yellow'><b>SUMO1 in yellow</b></font>, <font color='blue'><b>SAE1 colored in blue</b></font> and <font color='darkviolet'><b>other domains in darkviolet</b></font>). The catalytic Cys173 is shown in the spacefill representation and colored green, AMSN (or AVSN) are shown in the spacefill representation and colored in CPK colors. | For better understanding of the difference between these two conformations you can see this [[Morphs|morph]] (generated by using [http://polyview.cchmc.org/polyview3d.html POLYVIEW-3D: http://polyview.cchmc.org/polyview3d.html]; reload/refresh this page to restart this movie). Of note, in contrast to the previous figure, the same domains of these two structures ([[3kyc]] and [[3kyd]]) are colored in the same colors (<font color='yellow'><b>SUMO1 in yellow</b></font>, <font color='blue'><b>SAE1 colored in blue</b></font> and <font color='darkviolet'><b>other domains in darkviolet</b></font>). The catalytic Cys173 is shown in the spacefill representation and colored green, AMSN (or AVSN) are shown in the spacefill representation and colored in CPK colors. | ||
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| + | == 3D Structures of SUMO == | ||
| + | [[SUMO 3D Structures]] | ||
| + | |||
</StructureSection> | </StructureSection> | ||
{{Clear}} | {{Clear}} | ||
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* SUMO | * SUMO | ||
| - | + | **[[2n1v]], [[2mw5]], [[5ghd]], [[5b7a]], [[1a5r]] – hSUMO-1 - human - NMR<br /> | |
| - | + | **[[6j4i]] – hSUMO-1 (mutant) - NMR<br /> | |
| - | **[[2n1v]], [[2mw5]], [[5ghd]], [[ | + | |
**[[1wm2]], [[1wm3]], [[2awt]], [[4bkg]], [[4npn]] – hSUMO-2<br /> | **[[1wm2]], [[1wm3]], [[2awt]], [[4bkg]], [[4npn]] – hSUMO-2<br /> | ||
**[[2n1w]], [[5ghb]], [[5ghc]] – hSUMO-2 - NMR<br /> | **[[2n1w]], [[5ghb]], [[5ghc]] – hSUMO-2 - NMR<br /> | ||
**[[1u4a]] – hSUMO-3 (mutant) – NMR <br /> | **[[1u4a]] – hSUMO-3 (mutant) – NMR <br /> | ||
**[[5xqm]] – SUMO-1 - ''Caenorhabditis elegans'' - NMR<br /> | **[[5xqm]] – SUMO-1 - ''Caenorhabditis elegans'' - NMR<br /> | ||
| + | **[[2k8h]] – SUMO – NMR – ''Trypanosoma brucei''<br /> | ||
* SUMO+ubiquitin-like SUMO-conjugating enzyme | * SUMO+ubiquitin-like SUMO-conjugating enzyme | ||
| - | **[[2vrr]], [[2uyz]] – mSUMO-1+Ubc9<br /> | ||
**[[2pe6]] - hSUMO-1+Ubc9<br /> | **[[2pe6]] - hSUMO-1+Ubc9<br /> | ||
**[[3uip]], [[3uio]] - hSUMO-1+UBC9 + RAN GTPase-activating enzyme<br /> | **[[3uip]], [[3uio]] - hSUMO-1+UBC9 + RAN GTPase-activating enzyme<br /> | ||
**[[3uin]] - hSUMO-2+UBC9 + RAN GTPase-activating enzyme<br /> | **[[3uin]] - hSUMO-2+UBC9 + RAN GTPase-activating enzyme<br /> | ||
| + | **[[2vrr]], [[2uyz]] – mSUMO-1+Ubc9 - mouse<br /> | ||
* SUMO+sentrin specific protease | * SUMO+sentrin specific protease | ||
| - | **[[2io0]] – pre-hSUMO-2+SEPN2<br /> | ||
| - | **[[2io1]] - pre-hSUMO-3+SEPN2<br /> | ||
**[[2g4d]] - hSUMO-1+SEPN1<br /> | **[[2g4d]] - hSUMO-1+SEPN1<br /> | ||
**[[2iy1]] - hSUMO-1+SEPN1 (mutant)<br /> | **[[2iy1]] - hSUMO-1+SEPN1 (mutant)<br /> | ||
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**[[2io3]] - pre-hSUMO-2+SEPN2 (mutant)+RAN GTPase-activating enzyme (mutant)<br /> | **[[2io3]] - pre-hSUMO-2+SEPN2 (mutant)+RAN GTPase-activating enzyme (mutant)<br /> | ||
**[[2iy0]] - hSUMO-1+SEPN1 (mutant)+RAN GTPase-activating enzyme <br /> | **[[2iy0]] - hSUMO-1+SEPN1 (mutant)+RAN GTPase-activating enzyme <br /> | ||
| + | **[[2io0]] – pre-hSUMO-2+SEPN2<br /> | ||
| + | **[[6nnq]] - hSUMO-3 +SEPN1<br /> | ||
| + | **[[2io1]] - pre-hSUMO-3+SEPN2<br /> | ||
* SUMO+ubiquitin-conjugating enzyme | * SUMO+ubiquitin-conjugating enzyme | ||
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* SMT3 or ubiquitin-like protein Smt3 | * SMT3 or ubiquitin-like protein Smt3 | ||
| + | **[[2mp2]] – hSMT3 + RNF4<br /> | ||
**[[2k1f]] – SMT3 – ''Drosophila melanogaster''<br /> | **[[2k1f]] – SMT3 – ''Drosophila melanogaster''<br /> | ||
**[[1l2n]] – ySMT3 – yeast - NMR<br /> | **[[1l2n]] – ySMT3 – yeast - NMR<br /> | ||
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**[[3v62]] – ySMT3 + PCNA (mutant) + ATP-dependent DNA helicase SRS2<br /> | **[[3v62]] – ySMT3 + PCNA (mutant) + ATP-dependent DNA helicase SRS2<br /> | ||
**[[3qht]] – ySMT3 + monobody<br /> | **[[3qht]] – ySMT3 + monobody<br /> | ||
| - | **[[2io1]] – hSMT3 + Senp2<br /> | ||
| - | **[[2mp2]] – hSMT3 + RNF4<br /> | ||
* SUMO+other proteins | * SUMO+other proteins | ||
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**[[3kyc]], [[3kyd]] – hSUMO-1 +SUMO-activating enzyme <br /> | **[[3kyc]], [[3kyd]] – hSUMO-1 +SUMO-activating enzyme <br /> | ||
**[[5eql]] – hSUMO-1 + SUMO-adhiron-S2D5<br /> | **[[5eql]] – hSUMO-1 + SUMO-adhiron-S2D5<br /> | ||
| + | **[[5elj]] – hSUMO-1 + SUMO-affirmer<br /> | ||
**[[1wyw]] - hSUMO-1+thymine DNA glycosylate<br /> | **[[1wyw]] - hSUMO-1+thymine DNA glycosylate<br /> | ||
**[[2kqs]] - hSUMO-1+death domain-associated protein 6 fragment<br /> | **[[2kqs]] - hSUMO-1+death domain-associated protein 6 fragment<br /> | ||
**[[2las]] – hSUMO-1 + M-IR2 peptide<br /> | **[[2las]] – hSUMO-1 + M-IR2 peptide<br /> | ||
| - | **[[4wjn]], [[4wjo]] – hSUMO-1 (mutant) + PML<br /> | + | **[[4wjn]], [[4wjo]], [[6uyo]], [[6uyp]], [[6uyq]], [[6uyr]], [[6uys]], [[6uyt]], [[6uyu]], [[6uyv]] – hSUMO-1 (mutant) + PML<br /> |
| - | **[[4wjp]], [[4wjq]] – hSUMO-1 (mutant) + DAXX<br /> | + | **[[4wjp]], [[4wjq]], [[6uyx]], [[6uyy]], [[6uyz]] – hSUMO-1 (mutant) + DAXX<br /> |
**[[3rzw]] – hSUMO-1 (mutant) + monobody<br /> | **[[3rzw]] – hSUMO-1 (mutant) + monobody<br /> | ||
**[[2n1a]] – hSUMO-1 + CREB-binding protein - NMR<br /> | **[[2n1a]] – hSUMO-1 + CREB-binding protein - NMR<br /> | ||
| + | **[[6k5t]] – hSUMO-1 + IE2 peptide - NMR<br /> | ||
| + | **[[6jxx]], [[6jxw]], [[6jxv]], [[6jxu]] – hSUMO-2 + ICP0 peptide - NMR<br /> | ||
**[[2n9e]] – hSUMO-2 + RAP80 - NMR<br /> | **[[2n9e]] – hSUMO-2 + RAP80 - NMR<br /> | ||
**[[5eql]], [[5elu]] – hSUMO-2 + SUMO-adhiron-S2D5<br /> | **[[5eql]], [[5elu]] – hSUMO-2 + SUMO-adhiron-S2D5<br /> | ||
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**[[2rpq]] – hSUMO-3+activating transcription factor <br /> | **[[2rpq]] – hSUMO-3+activating transcription factor <br /> | ||
**[[2d07]] - hSUMO-3+thymine DNA glycosylate<br /> | **[[2d07]] - hSUMO-3+thymine DNA glycosylate<br /> | ||
| + | **[[6k5r]] – hSUMO-3 + IE2 peptide - NMR<br /> | ||
**[[5jp1]] – SUMO + xanthomonas outer protein D - tomato<br /> | **[[5jp1]] – SUMO + xanthomonas outer protein D - tomato<br /> | ||
Revision as of 11:02, 11 February 2020
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3D Structures of SUMO
Updated on 11-February-2020
Reference
- ↑ Sarge KD, Park-Sarge OK. Sumoylation and human disease pathogenesis. Trends Biochem Sci. 2009 Apr;34(4):200-5. doi: 10.1016/j.tibs.2009.01.004. Epub, 2009 Mar 11. PMID:19282183 doi:http://dx.doi.org/10.1016/j.tibs.2009.01.004
- ↑ Olsen SK, Capili AD, Lu X, Tan DS, Lima CD. Active site remodelling accompanies thioester bond formation in the SUMO E1. Nature. 2010 Feb 18;463(7283):906-12. PMID:20164921 doi:10.1038/nature08765
