SUMO

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</StructureSection>
</StructureSection>
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== 3D Structures of SUMO ==
 
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 
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{{#tree:id=OrganizedByTopic|openlevels=0|
 
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* SUMO
 
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**[[2n1v]], [[2mw5]], [[5ghd]], [[5b7a]], [[1a5r]] – hSUMO-1 - human - NMR<br />
 
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**[[6j4i]] – hSUMO-1 (mutant) - NMR<br />
 
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**[[1wm2]], [[1wm3]], [[2awt]], [[4bkg]], [[4npn]] – hSUMO-2<br />
 
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**[[2n1w]], [[5ghb]], [[5ghc]] – hSUMO-2 - NMR<br />
 
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**[[1u4a]] – hSUMO-3 (mutant) – NMR <br />
 
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**[[5xqm]] – SUMO-1 - ''Caenorhabditis elegans'' - NMR<br />
 
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**[[2k8h]] – SUMO – NMR – ''Trypanosoma brucei''<br />
 
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* SUMO+ubiquitin-like SUMO-conjugating enzyme
 
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**[[2pe6]] - hSUMO-1+Ubc9<br />
 
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**[[3uip]], [[3uio]] - hSUMO-1+UBC9 + RAN GTPase-activating enzyme<br />
 
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**[[3uin]] - hSUMO-2+UBC9 + RAN GTPase-activating enzyme<br />
 
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**[[2vrr]], [[2uyz]] – mSUMO-1+Ubc9 - mouse<br />
 
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* SUMO+sentrin specific protease
 
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**[[2g4d]] - hSUMO-1+SEPN1<br />
 
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**[[2iy1]] - hSUMO-1+SEPN1 (mutant)<br />
 
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**[[2iyd]], [[2ckh]], [[3zo5]] - hSUMO-2+SEPN1<br />
 
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**[[1tgz]] - hSUMO-1+SEPN2<br />
 
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**[[5aek]] - hSUMO-1 (mutant) +SEPN2 (mutant)<br />
 
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**[[2io3]] - pre-hSUMO-2+SEPN2 (mutant)+RAN GTPase-activating enzyme (mutant)<br />
 
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**[[2iy0]] - hSUMO-1+SEPN1 (mutant)+RAN GTPase-activating enzyme <br />
 
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**[[2io0]] – pre-hSUMO-2+SEPN2<br />
 
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**[[6nnq]] - hSUMO-3 +SEPN1<br />
 
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**[[2io1]] - pre-hSUMO-3+SEPN2<br />
 
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* SUMO+ubiquitin-conjugating enzyme
 
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**[[1z5s]] - hSUMO-1+E2+ RAN GTPase-activating enzyme<br />
 
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**[[5d2m]] - hSUMO-2+E2+ RAN GTPase-activating enzyme + ZNF451<br />
 
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**[[2bf8]] - SUMO-1+E2 - bovine<br />
 
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* SMT3 or ubiquitin-like protein Smt3
 
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**[[2mp2]] – hSMT3 + RNF4<br />
 
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**[[2k1f]] – SMT3 – ''Drosophila melanogaster''<br />
 
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**[[1l2n]] – ySMT3 – yeast - NMR<br />
 
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**[[2eke]] – ySMT3+UBC9 <br />
 
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**[[1euv]] – ySMT3+ULP1 protease<br />
 
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**[[3v60]], [[3v61]] – ySMT3 + PCNA (mutant)<br />
 
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**[[3v62]] – ySMT3 + PCNA (mutant) + ATP-dependent DNA helicase SRS2<br />
 
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**[[3qht]] – ySMT3 + monobody<br />
 
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* SUMO+other proteins
 
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**[[2asq]] – hSUMO-1+SUMO-binding motif in PIASX<br />
 
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**[[3kyc]], [[3kyd]] – hSUMO-1 +SUMO-activating enzyme <br />
 
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**[[5eql]] – hSUMO-1 + SUMO-adhiron-S2D5<br />
 
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**[[5elj]] – hSUMO-1 + SUMO-affirmer<br />
 
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**[[1wyw]] - hSUMO-1+thymine DNA glycosylate<br />
 
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**[[2kqs]] - hSUMO-1+death domain-associated protein 6 fragment<br />
 
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**[[2las]] – hSUMO-1 + M-IR2 peptide<br />
 
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**[[4wjn]], [[4wjo]], [[6uyo]], [[6uyp]], [[6uyq]], [[6uyr]], [[6uys]], [[6uyt]], [[6uyu]], [[6uyv]] – hSUMO-1 (mutant) + PML<br />
 
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**[[4wjp]], [[4wjq]], [[6uyx]], [[6uyy]], [[6uyz]] – hSUMO-1 (mutant) + DAXX<br />
 
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**[[3rzw]] – hSUMO-1 (mutant) + monobody<br />
 
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**[[2n1a]] – hSUMO-1 + CREB-binding protein - NMR<br />
 
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**[[6k5t]] – hSUMO-1 + IE2 peptide - NMR<br />
 
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**[[6jxx]], [[6jxw]], [[6jxv]], [[6jxu]] – hSUMO-2 + ICP0 peptide - NMR<br />
 
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**[[2n9e]] – hSUMO-2 + RAP80 - NMR<br />
 
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**[[5eql]], [[5elu]] – hSUMO-2 + SUMO-adhiron-S2D5<br />
 
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**[[5tvq]] – hSUMO-2 + tyrosyl-DNA phosphodiesterase<br />
 
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**[[5tvp]] – hSUMO-2 + tyrosyl-DNA phosphodiesterase + DNA<br />
 
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**[[2mp2]] – hSUMO-3 + E3 ubiquitin protein ligase<br />
 
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**[[2rpq]] – hSUMO-3+activating transcription factor <br />
 
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**[[2d07]] - hSUMO-3+thymine DNA glycosylate<br />
 
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**[[6k5r]] – hSUMO-3 + IE2 peptide - NMR<br />
 
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**[[5jp1]] – SUMO + xanthomonas outer protein D - tomato<br />
 
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}}
 
==Reference==
==Reference==
<references/>
<references/>

Revision as of 11:03, 11 February 2020

Human SUMO-1 (yellow) complex with SUMO-activating enzyme subunit 1 (grey), SUMO-activating enzyme subunit 2 (green), adenosine derivative and Zn+2 ion (grey) (PDB code 3kyc)

Drag the structure with the mouse to rotate

Reference

  1. ↑ Sarge KD, Park-Sarge OK. Sumoylation and human disease pathogenesis. Trends Biochem Sci. 2009 Apr;34(4):200-5. doi: 10.1016/j.tibs.2009.01.004. Epub, 2009 Mar 11. PMID:19282183 doi:http://dx.doi.org/10.1016/j.tibs.2009.01.004
  2. ↑ Olsen SK, Capili AD, Lu X, Tan DS, Lima CD. Active site remodelling accompanies thioester bond formation in the SUMO E1. Nature. 2010 Feb 18;463(7283):906-12. PMID:20164921 doi:10.1038/nature08765

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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