Receptor
From Proteopedia
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These receptors are typically the targets of fast neurotransmitters such as acetylcholine (nicotinic) and GABA; activation of these receptors results in changes in ion movement across a membrane. | These receptors are typically the targets of fast neurotransmitters such as acetylcholine (nicotinic) and GABA; activation of these receptors results in changes in ion movement across a membrane. | ||
*[[Ionotropic receptors]] | *[[Ionotropic receptors]] | ||
| - | + | **[[5-hydroxytryptamine receptor#Structural highlights/Specific Function of 5-HT3]] | |
| - | *[[5-hydroxytryptamine receptor#Structural highlights/Specific Function of 5-HT3]] | + | **[[Journal:JBSD:16|The extracellular subunit interface of the 5-HT3 receptors: a computational alanine scanning mutagenesis study]]<ref>DOI 10.1080/07391102.2012.680029</ref> |
| - | *[[Journal:JBSD:16|The extracellular subunit interface of the 5-HT3 receptors: a computational alanine scanning mutagenesis study]]<ref>DOI 10.1080/07391102.2012.680029</ref> | + | **[[5-hydroxytryptamine receptor#5-HT3 receptor antagonists]] |
| - | *[[5-hydroxytryptamine receptor#5-HT3 receptor antagonists]] | + | **[[Nicotinic Acetylcholine Receptor|Nicotinic Acetylcholine Receptors in general]] |
| - | *[[Nicotinic Acetylcholine Receptor|Nicotinic Acetylcholine Receptors in general]] | + | **[[Alpha-bungarotoxin]] is a nicotinic cholinergic antagonist that is found within the venom of ''Bungarus multicinctus'', a South-asian snake belonging to a group commonly known as kraits. |
| - | *[[Alpha-bungarotoxin]] is a nicotinic cholinergic antagonist that is found within the venom of ''Bungarus multicinctus'', a South-asian snake belonging to a group commonly known as kraits. | + | **[[Binding site of AChR]] |
| - | *[[Binding site of AChR]] | + | **[[Acetylcholine Receptor and its Reaction to Cobra Venom]] |
| - | *[[Acetylcholine Receptor and its Reaction to Cobra Venom]] | + | **[[Molecular Playground/Glutamate Receptor|AMPA glutamate receptor]] by [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground]. |
| - | *[[Molecular Playground/Glutamate Receptor|AMPA glutamate receptor]] by [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground]. | + | **[[Glutamate receptor (GluA2)]] |
| - | *[[Glutamate receptor (GluA2)]] | + | |
==G protein-linked (metabotropic) receptors== | ==G protein-linked (metabotropic) receptors== | ||
This is the largest family of receptors and includes the receptors for several hormones and slow transmitters(dopamine, metabotropic glutamate). They are composed of seven transmembrane alpha helices. The loops connecting the alpha helices form extracellular and intracellular domains. The binding-site for larger peptide ligands is usually located in the extracellular domain whereas the binding site for smaller non-peptide ligands is often located between the seven alpha helices and one extracellular loop. These receptors are coupled to different intracellular effector systems via G proteins | This is the largest family of receptors and includes the receptors for several hormones and slow transmitters(dopamine, metabotropic glutamate). They are composed of seven transmembrane alpha helices. The loops connecting the alpha helices form extracellular and intracellular domains. The binding-site for larger peptide ligands is usually located in the extracellular domain whereas the binding site for smaller non-peptide ligands is often located between the seven alpha helices and one extracellular loop. These receptors are coupled to different intracellular effector systems via G proteins | ||
*[[G protein-coupled receptor|G protein-coupled receptors]] | *[[G protein-coupled receptor|G protein-coupled receptors]] | ||
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**[[Neurotensin receptor]] | **[[Neurotensin receptor]] | ||
**[[CXC chemokine receptor type 4]] | **[[CXC chemokine receptor type 4]] | ||
Revision as of 13:33, 8 April 2021
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References
- ↑ De Rienzo F, Moura Barbosa AJ, Perez MA, Fernandes PA, Ramos MJ, Menziani MC. The extracellular subunit interface of the 5-HT(3) receptors: a computational alanine scanning mutagenesis study. J Biomol Struct Dyn. 2012 Jul;30(3):280-98. Epub 2012 Jun 12. PMID:22694192 doi:10.1080/07391102.2012.680029
- ↑ Segaliny AI, Tellez-Gabriel M, Heymann MF, Heymann D. Receptor tyrosine kinases: Characterisation, mechanism of action and therapeutic interests for bone cancers. J Bone Oncol. 2015 Jan 23;4(1):1-12. doi: 10.1016/j.jbo.2015.01.001. eCollection , 2015 Mar. PMID:26579483 doi:http://dx.doi.org/10.1016/j.jbo.2015.01.001
