Troponin
From Proteopedia
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<StructureSection load='1yv0' size='350' side='right' caption='Chicken troponin: subunit T (dark green), subunit I (wheat), subunit C (pink) complex with Mg+2 ion (green) [[1yv0]]' scene=''> | <StructureSection load='1yv0' size='350' side='right' caption='Chicken troponin: subunit T (dark green), subunit I (wheat), subunit C (pink) complex with Mg+2 ion (green) [[1yv0]]' scene=''> | ||
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== Function == | == Function == | ||
[[Troponin]] (Tn) is a regulatory protein in muscle contraction. It contains 3 subunits:<br /> | [[Troponin]] (Tn) is a regulatory protein in muscle contraction. It contains 3 subunits:<br /> | ||
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== Disease == | == Disease == | ||
Mutations in TnI<ref>PMID:9241277</ref> and TnT <ref>PMID:11606294</ref>are associated with hypertrophic cardiomyopathy. | Mutations in TnI<ref>PMID:9241277</ref> and TnT <ref>PMID:11606294</ref>are associated with hypertrophic cardiomyopathy. | ||
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| + | == 3D Structures of Troponin == | ||
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| + | [[Troponin 3D structures]] | ||
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</StructureSection> | </StructureSection> | ||
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== 3D Structures of Troponin == | == 3D Structures of Troponin == | ||
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**[[1j1d]], [[1j1e]], [[4y99]] – hTnC (mutant)+hTnI (mutant) fragment+hTnT fragment+Ca - human<br /> | **[[1j1d]], [[1j1e]], [[4y99]] – hTnC (mutant)+hTnI (mutant) fragment+hTnT fragment+Ca - human<br /> | ||
**[[6kn8]], [[6kn7]] - hTnC + hTnI + hTnT + actin + tropomyosin – Cryo EM<br /> | **[[6kn8]], [[6kn7]] - hTnC + hTnI + hTnT + actin + tropomyosin – Cryo EM<br /> | ||
| + | **[[7ko4]], [[7ko5]], [[7ko7]], [[7kon]], [[7kor]] - pTnC + pTnI + pTnT + actin + tropomyosin – pig - Cryo EM<br /> | ||
**[[6klu]], [[6klt]] - mTnC + TnI + TnT – mouse - Cryo EM<br /> | **[[6klu]], [[6klt]] - mTnC + TnI + TnT – mouse - Cryo EM<br /> | ||
**[[2w49]], [[2w4u]] – cTnC+cTnI+cTnT+tropomyosin+actin – chicken<br /> | **[[2w49]], [[2w4u]] – cTnC+cTnI+cTnT+tropomyosin+actin – chicken<br /> | ||
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**[[2krd]], [[2mkp]] – hTnC+hTnI + Ca – NMR<br /> | **[[2krd]], [[2mkp]] – hTnC+hTnI + Ca – NMR<br /> | ||
**[[6mv3]], [[7jgi]] – hTnC/hTnI (mutant) – NMR<br /> | **[[6mv3]], [[7jgi]] – hTnC/hTnI (mutant) – NMR<br /> | ||
| - | **[[5vln]], [[5wcl]], [[5w88]] – hTnC N-domain (mutant)/hTnI swich region – NMR<br /> | + | **[[7sc2]], [[7sc3]], [[7sxd]] – hTnC N-domain/hTnI switch region<br /> |
| + | **[[5vln]], [[5wcl]], [[5w88]], [[7sxc]] – hTnC N-domain (mutant)/hTnI swich region – NMR<br /> | ||
| + | **[[7kaa]] – hTnC N-domain/hTnI switch region + drug – NMR<br /> | ||
| + | **[[7jgi]], [[7sup]], [[7svc]], [[7swg]], [[7swi]] – hTnC N-domain/hTnI switch region + inhibitor – NMR<br /> | ||
**[[1ozs]] - hTnC C-terminal+hTnI N-terminal – NMR<br /> | **[[1ozs]] - hTnC C-terminal+hTnI N-terminal – NMR<br /> | ||
**[[2l1r]] - hTnC C-terminal+hTnI switch region - NMR<br /> | **[[2l1r]] - hTnC C-terminal+hTnI switch region - NMR<br /> | ||
Revision as of 10:07, 18 May 2022
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3D Structures of Troponin
Updated on 18-May-2022
References
- ↑ Li MX, Hwang PM. Structure and function of cardiac troponin C (TNNC1): Implications for heart failure, cardiomyopathies, and troponin modulating drugs. Gene. 2015 Oct 25;571(2):153-66. doi: 10.1016/j.gene.2015.07.074. Epub 2015 Jul, 29. PMID:26232335 doi:http://dx.doi.org/10.1016/j.gene.2015.07.074
- ↑ Kimura A, Harada H, Park JE, Nishi H, Satoh M, Takahashi M, Hiroi S, Sasaoka T, Ohbuchi N, Nakamura T, Koyanagi T, Hwang TH, Choo JA, Chung KS, Hasegawa A, Nagai R, Okazaki O, Nakamura H, Matsuzaki M, Sakamoto T, Toshima H, Koga Y, Imaizumi T, Sasazuki T. Mutations in the cardiac troponin I gene associated with hypertrophic cardiomyopathy. Nat Genet. 1997 Aug;16(4):379-82. PMID:9241277 doi:10.1038/ng0897-379
- ↑ Palm T, Graboski S, Hitchcock-DeGregori SE, Greenfield NJ. Disease-causing mutations in cardiac troponin T: identification of a critical tropomyosin-binding region. Biophys J. 2001 Nov;81(5):2827-37. PMID:11606294 doi:http://dx.doi.org/10.1016/S0006-3495(01)75924-3
