Citric Acid Cycle

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*[[Krebs cycle overview]]
*[[Krebs cycle overview]]
*[[Krebs cycle reactions]]
*[[Krebs cycle reactions]]
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*[[Major metabolic pathways converging on the citric acid cycle]]
 
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*[[Citric acid cycle intermediates serve as substrates for biosynthetic processes]]
 
The [[Citric Acid Cycle]] (tricarboxylic acid cycle) is a series of enzyme catalyzed reactions which are critical in cellular respiration. Under oxidative conditions, pyruvate continues to be metabolized through the tricarboxylic acid cycle. In this cycle, Acetyl-CoA, a byproduct of [[glycolysis]], along with various cofactors, are broken down into carbon dioxide, water, and energy in the form of GTP and NADH.
The [[Citric Acid Cycle]] (tricarboxylic acid cycle) is a series of enzyme catalyzed reactions which are critical in cellular respiration. Under oxidative conditions, pyruvate continues to be metabolized through the tricarboxylic acid cycle. In this cycle, Acetyl-CoA, a byproduct of [[glycolysis]], along with various cofactors, are broken down into carbon dioxide, water, and energy in the form of GTP and NADH.
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*[[2-Oxoglutarate Dehydrogenase]]
*[[2-Oxoglutarate Dehydrogenase]]
*Step 5 = [[Krebs cycle step 4]]
*Step 5 = [[Krebs cycle step 4]]
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5C α-Ketoglutarate => <scene name='43/430893/Cv/9'>Succinyl-CoA</scene> 4C chain (CoA excluded). The succinyl-CoA formed during [[Beta oxidationcan]] also can enter the [[Citric Acid Cycle]].
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5C α-Ketoglutarate => <scene name='43/430893/Cv/9'>Succinyl-CoA</scene> 4C chain (CoA excluded)
'''Step 6 - Substrate-level phosphorylation - Succinyl-CoA synthetase'''
'''Step 6 - Substrate-level phosphorylation - Succinyl-CoA synthetase'''

Revision as of 15:37, 16 February 2023

Open conformation of citrate synthase dimer complex with citrate (PDB code 1cts) and closed conformation of citrate synthase dimer complex with citrate and CoA (PDB code 2cts)

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Alexander Berchansky, David Canner, Ann Taylor, Wayne Decatur, Jaime Prilusky

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