Microtubule-associated protein light chain 3 (LC3) is recruited to autophagosomal membranes during autophagy. The human LC3B is cleaved after synthesis to expose a C-terminal glycine which binds via a phospholipid anchor to autophagosomal vescicle membranes during autophagy. Thus detection of LC3 is a reliable method for monitoring autophagy. The microtubule-associated proteins are classsified as 2 types. Type 1 includes MAP1 and type 2 includes MAP2, MAP4 and tau protein Tau protein.
Function
Disease
Microtubule-associated protein Tau is associated with Alzheimer Disease. Tau forms abnormal aggregates in patients' tissues.
Relevance
Structural highlights
