User:Alexander Berchansky

From Proteopedia

Revision as of 13:31, 2 July 2018

Dr. Alexander Berchansky, Ph.D., Israel Structural Proteomics Center, Weizmann Institute of Science

Interesting pages:

• Acetylcholinesterase
• AChE inhibitors and substrates
• Mutations in BRCA1/BARD1 RING-domain heterodimer
• Mutations in Brca1 BRCT Domains
• Missense Mutations in Phenylalanine Hydroxylase
• A hydrogen-bonding network formed by the B10-E7-E11 residues of a truncated hemoglobin from Tetrahymena pyriformis is critical for stability of bound oxygen and nitric oxide detoxification
• Phosphofructokinase (PFK)
• Alcohol dehydrogenase
• Beta-glucosidase
• Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations
• A DNA structural alphabet provides new insight into DNA flexibility
• Crystal structure of ADL1, a plant-specific homologue of the universal diaminopimelate amino transferase enzyme of lysine biosynthesis
• Structure of recombinant human carboxylesterase 1 isolated from whole cabbage looper larvae
• Fine tuning of chlorophyll spectra by protein-induced ring deformation
• Xanthine dehydrogenase
• N-Butylisocyanide Oxidation at the [NiFe₄S₄OH_x]-cluster of CO Dehydrogenase
• Multifaceted SlyD from Helicobacter pylori: implication in [NiFe] hydrogenase maturation
• Potent Inhibition of Dinuclear Zinc(II) Peptidase, an Aminopeptidase from Aeromonas proteolytica, by 8-Quinolinol Derivatives: Inhibitor Design Based on Zn2+ Fluorophores, Kinetic, and X-ray Crystallographic Study
• Laue Crystal Structure of Shewanella oneidensis Cytochrome c Nitrite Reductase from a High-yield Expression System
• Peptidylglycine α-Hydroxylating Monooxygenase (PHM)-coordination of peroxide to Cu_M center. Structural and computational study
• Solution structure and dynamics of human S100A14
• The crystal structure of Sporosarcina pasteurii urease in a complex with citrate provides new hints for inhibitor design
• The mechanism of copper uptake by tyrosinase from Bacillus megaterium
• The crystal structure of an extracellular catechol oxidase from the ascomycete fungus Aspergillus oryzae
• Selectivity of Ni(II) and Zn(II) binding to Sporosarcina pasteurii UreE, a metallo-chaperone in the urease assembly: a calorimetric and crystallographic study
• Solution structure and metal ion binding sites of the human CPEB3 ribozyme's P4 domain
• Synthesis, characterization and binding properties towards CT-DNA and Lipoxygenase, of mixed ligand silver(I) complexes with 2-mercapto-thiazole and its derivatives and triphenylphosphine.
• Fluoride inhibition of Sporosarcina pasteurii urease: structure and thermodynamics
• Aromatic aldehydes at the active site of Aldehyde Oxidoreductase from Desulfovibrio gigas: Reactivity and Molecular Details of the Enzyme-Substrate and Enzyme-Product Interactions
• Crystallographic studies of [NiFe]-hydrogenase mutants: towards consensus structures for the elusive unready oxidized states
• High-resolution crystal structure of Z-DNA in complex with Cr3+ cations
• Structural Characterization of Metal Binding to a Cold-adapted Frataxin
• Conformational control of the binding of diatomic gases to cytochrome c’
• Analyzing the Catalytic Role of Active Site Residues in the Fe-Type Nitrile Hydratase from Comamonas testosteroni Ni1
• Structural characterization of zinc-bound Zmp1, a zinc-dependent metalloprotease secreted by Clostridium difficile
• Structural evidence for Arabidopsis glutathione transferase AtGSTF2 functioning as a transporter of small organic ligands
• Crystal structure of porcine pancreatic phospholipase A₂ in complex with 2-methoxycyclohexa-2-5-diene-1,4-dione
• A DNA Structural Alphabet Distinguishes Structural Features of DNA Bound to Regulatory Proteins and in the Nucleosome Core Particle
• Structural and kinetic studies of imidazole binding to two members of the cytochrome c6 family reveal an important role for a conserved heme pocket residue
• Protein and metal cluster structure of the wheat metallothionein domain γ-Ec-1. The second part of the puzzle.
• Ferredoxin
• A Cryo-Crystallographic Time Course for Peroxide Reduction by Rubrerythrin from Pyrococcus furiosus
• Cyt1Aa Toxin: High Resolution Structure Reveals Implications for its Membrane-Perforating Function
• Catalytic metal ion rearrangements underline promiscuity and evolvability of a metalloenzyme
• Structure of estradiol metal chelate and estrogen receptor complex: The basis for designing a new class of SERMs
• Structural and functional insights into a dodecameric molecular machine – The RuvBL1/RuvBL2 complex
• Automated computational design of human enzymes for high bacterial expression and stability
• Antiviral Activity of 3(2H)- and 6-Chloro-3(2H)-Isoflavenes against Highly Diverged, Neurovirulent Vaccine-Derived, Type2 Poliovirus Sewage Isolates
• Structural Basis of Enzymatic Activity for the Ferulic Acid Decarboxylase (FADase) from Enterobacter sp. Px6-4
• Structural and functional characterization of the interaction of the photosensitizing probe methylene blue with Torpedo californica acetylcholinesterase
• The Impact of Crystallization Conditions on Structure-Based Drug Design: a Case Study on the Methylene Blue/Acetylcholinesterase Complex
• Structural basis of transcription activation
• Promiscuous Protein Binding as a Function of Protein Stability
• An Insight to the Dynamics of Conserved Water Mediated Salt Bridge Interaction and Inter-Domain Recognition in hIMPDH Isoforms
• Elucidation by NMR solution of neurotensin in Small Unilamellar Vesicle environment: molecular surveys for neurotensin receptor recognition
• Dominant-negative Effects in Prion Diseases: Insights from Molecular Dynamics Simulations on Mouse Prion Protein Chimeras
• Influence of divalent magnesium ion on DNA: molecular dynamics simulation studies
• Evidence-based docking of the urease activation complex
• Carbon monoxide binding to the heme group at the dimeric interface modulates structure and copper accessibility in the Cu,Zn superoxide dismutase from Haemophilus ducreyi: in silico and in vitro evidences
• Para-(benzoyl)-phenylalanine as a potential inhibitor against LpxC of Leptospira spp.: Homology modeling, docking and molecular dynamics study
• Drug resistance mechanism of PncA in Mycobacterium Tuberculosis
• Mechanism of BAG1 repair on Parkinson’s disease-linked DJ1 mutation
• Traditional Chinese medicine as dual guardians against hypertension and cancer?