Hormones and their receptors
From Proteopedia
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<StructureSection load='' size='300' side='right' caption='Human prolactin receptor (deepskyblue) complex with prolactin (magenta), Na+ (purple) and Cl- (green) ions (PDB code [[3mzg]])' scene='74/749401/Cv/1'> | <StructureSection load='' size='300' side='right' caption='Human prolactin receptor (deepskyblue) complex with prolactin (magenta), Na+ (purple) and Cl- (green) ions (PDB code [[3mzg]])' scene='74/749401/Cv/1'> | ||
| - | '''Under development!!!''' | ||
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=Peptide/protein & many eicosanoid hormones act via Transmembrane (cell surface) receptors= | =Peptide/protein & many eicosanoid hormones act via Transmembrane (cell surface) receptors= | ||
[[Receptor|Receptors]] for most peptide/protein as well as many eicosanoid hormones are embedded in the plasma membrane at the surface of the cell and the majority of these receptors belong to the [[G protein-coupled receptor]] (GPCR). The interaction of hormone and receptor typically triggers a cascade of secondary effects within the cytoplasm of the cell, described as signal transduction, often involving phosphorylation or dephosphorylation of various other cytoplasmic proteins, changes in ion channel permeability, or increased concentrations of intracellular molecules that may act as secondary messengers (e.g., cyclic AMP). | [[Receptor|Receptors]] for most peptide/protein as well as many eicosanoid hormones are embedded in the plasma membrane at the surface of the cell and the majority of these receptors belong to the [[G protein-coupled receptor]] (GPCR). The interaction of hormone and receptor typically triggers a cascade of secondary effects within the cytoplasm of the cell, described as signal transduction, often involving phosphorylation or dephosphorylation of various other cytoplasmic proteins, changes in ion channel permeability, or increased concentrations of intracellular molecules that may act as secondary messengers (e.g., cyclic AMP). | ||
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==Glucagon-like peptide 1 receptor (GPCR Subfamily B1)== | ==Glucagon-like peptide 1 receptor (GPCR Subfamily B1)== | ||
| + | * [[GLP-1]] | ||
* [[Glucagon-like peptide 1 receptor]] | * [[Glucagon-like peptide 1 receptor]] | ||
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=Steroid & thyroid hormones act via Intracellular receptors (nuclear receptors)= | =Steroid & thyroid hormones act via Intracellular receptors (nuclear receptors)= | ||
| - | For steroid or thyroid hormones, their receptors are located inside the cell within the cytoplasm of the target cell. These receptors belong to the nuclear receptor family of ligand-activated transcription factors. To bind their receptors, these hormones must first cross the cell membrane. They can do so because they are lipid-soluble. The combined hormone-receptor complex then moves across the nuclear membrane into the nucleus of the cell, where it binds to specific DNA sequences, regulating the expression of certain genes, and thereby increasing the levels of the proteins encoded by these genes. | + | For steroid or thyroid hormones, their receptors are located inside the cell within the cytoplasm of the target cell. These receptors belong to the nuclear receptor family of ligand-activated transcription factors. To bind their receptors, these hormones must first cross the cell membrane. They can do so because they are lipid-soluble. The combined hormone-receptor complex then moves across the nuclear membrane into the nucleus of the cell, where it binds to specific DNA sequences, regulating the expression of certain genes, and thereby increasing the levels of the proteins encoded by these genes. See also [[Steroid Hormones and their receptors]]. |
'''However, it has been shown that not all steroid receptors are located inside the cell. Some are associated with the plasma membrane.''' | '''However, it has been shown that not all steroid receptors are located inside the cell. Some are associated with the plasma membrane.''' | ||
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=See also= | =See also= | ||
*[[Hormone]] | *[[Hormone]] | ||
| - | *[[Growth factors]] | + | *[[Growth factors]] |
| + | *[[Steroid Hormones and their receptors]] | ||
| + | *[[Lipid signaling]] | ||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Current revision
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References
- ↑ Li MJ, Greenblatt HM, Dym O, Albeck S, Pais A, Gunanathan C, Milstein D, Degani H, Sussman JL. Structure of estradiol metal chelate and estrogen receptor complex: The basis for designing a new class of selective estrogen receptor modulators. J Med Chem. 2011 Apr 7. PMID:21473635 doi:10.1021/jm200192y
