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Troponin

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[[Image:1yv0.png|left|200px|thumb|Crystal Structure of Troponin [[1yv0]]]]
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{{STRUCTURE_1yv0| PDB=1yv0 | SIZE=400| SCENE=Troponin/Cv/1 |right|CAPTION=Chicken troponin: subunit T (dark green), subunit I (wheat), subunit C (pink) complex with Mg+2 ion (green) [[1yv0]] }}
{{STRUCTURE_1yv0| PDB=1yv0 | SIZE=400| SCENE=Troponin/Cv/1 |right|CAPTION=Chicken troponin: subunit T (dark green), subunit I (wheat), subunit C (pink) complex with Mg+2 ion (green) [[1yv0]] }}
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[[Troponin]] (Tn) is a regulatory protein in muscle contraction. It contains 3 subunits:<br />
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* '''TnC''' causes conformational change in TnI when it binds to calcium ions. For more details on TnC see [[ Role of Troponin C in decreased muscle sensitivity to calcium]].<br />
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* '''TnT''' binds to [[Tropomyosin|tropomyosin]].<br />
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* '''TnI''' binds to actin which is found in thin muscle filaments.<br />
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See additional details in [[Human Cardiac Troponin C]].
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[[Troponin]] (Tn) is a regulatory protein in muscle contraction. It contains 3 subunits: TnC causes conformational change in TnI when it binds to calcium ions. For more details on TnC see [[ Role of Troponin C in decreased muscle sensitivity to calcium]]. TnT binds to [[Tropomyosin|tropomyosin]] and TnI binds to actin which is found in thin muscle filaments. The images at the left and at the right correspond to one representative Tn, ''i.e.'' the crystal structure of complex Troponin C/Troponin I/Troponin T ([[1yv0]]). See additional details in [[Human Cardiac Troponin C]].
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== 3D Structures of Troponin ==
== 3D Structures of Troponin ==

Revision as of 08:22, 21 August 2014

Template:STRUCTURE 1yv0

Troponin (Tn) is a regulatory protein in muscle contraction. It contains 3 subunits:

See additional details in Human Cardiac Troponin C.

Contents

3D Structures of Troponin

Updated on 21-August-2014

Troponin C+Troponin I+Troponin T

2w49, 2w4u – cTnC+cTnI+cTnT+tropomyosin+actin – chicken
1ytz - cTnC+cTnI+cTnT+Ca++
1yv0 - cTnC+cTnI+cTnT
1j1d, 1j1e – hTnC (mutant)+hTnI (mutant) fragment+hTnT fragment+Ca++ - human

Troponin C+Troponin I

2krd, 2mkp – hTnC+hTnI – NMR
1ozs - hTnC C-terminal+hTnI N-terminal – NMR
2l1r - hTnC C-terminal+hTnI switch region - NMR
1lxf, 1mxl - hTnC N-terminal+hTnI fragment
2kgb – hTnC (mutant) regulatory domain+TnI
1sbj – cTnC C-terminal+cTnI N-terminal+Mg++ - NMR
1scv, 1fi5, 1blq - cTnC C-terminal+cTnI N-terminal – NMR
1npq - cTnC (mutant) N-terminal+cTnI fragment+rhodamine
1jc2 - cTnC C-terminal+cTnI N-terminal
1a2x - rTnC +rTnI fragment – rabbit
3tz1 - TnC C terminal +TnI fragment – akazara scallop

Troponin C

2kdh – hTnC+green tea polyphenol – NMR
2kfx – hTnC (mutant) N-terminal+Ca+naphthalene derivative
2jt0, 2jtz, 2jt8, 2jt3 – hTnC (mutant) – NMR
2jxl - hTnC (mutant) N-terminal – NMR
3rv5, 3sd6, 3swb - hTnC N-terminal
4gjg - hTnC N-terminal (mutant)
4gjf - hTnC N-terminal (mutant) + Cd
4gje - hTnC N-terminal + Cd
1wrk, 1wrl - hTnC (mutant) N-terminal+trifluoperazine
1spy - hTnC N-terminal – NMR
2mle - hTnC C-terminal – NMR
2mlf - hTnC C-terminal (mutant) – NMR
1ih0 - hTnC C-terminal+EMD 57033 – NMR
1ap4 - hTnC N-terminal+Ca++ – NMR
2l98 – hTnC EF-hand domains 3,4 + resveratrol
1la0, 4tnc – cTnC+Ca++
1dtl – cTnC (mutant)+Ca++ +bepridil
1skt, 1zac, 2ctn - cTnC N-terminal – NMR
1aj4 - cTnC (mutant) +Ca++ – NMR
3ctn - cTnC C-terminal – NMR
1avs - cTnC N-terminal+Ca++
1smg, 1tnq - cTnC N-terminal+Ca++ - NMR
1ncy – cTnC+Mn++
1ncx, 1ncz, 1top – cTnC
1pon, 1cta, 1ctd – cTnC fragment – NMR
1tnp - cTnC N-terminal – NMR
1tnw, 1tnx - cTnC +Ca++ - NMR
1trf - tTnC N-terminal+Ca++ - turkey – NMR
5tnc - tTnC
2k2a - TnC C-terminal – Lethocerus indicus – NMR
2jnf – TnC – fly – NMR
1r2u, 1r6p - TnC N-terminal – trout – NMR
1tcf – rTnC+Ca++
1tn4, 2tn4 – rTnC (mutant)+Ca++

Troponin I

2jpw – TnI biphosphorylated – mouse – NMR
1vdi – cTnI – NMR
1vdj – cTnI+Ca++ - NMR

Troponin T

2z5h – yTnT fragment+tropomyosin – yeast

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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