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Flaps Morph for HIV Protease
From Proteopedia
(Difference between revisions)
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*Course-grained<ref>PMID:17029846 </ref> | *Course-grained<ref>PMID:17029846 </ref> | ||
*2017: [https://pubs.rsc.org/en/content/articlehtml/2017/ra/c7ra09691g Structural insights into HIV-1 protease flap opening processes and key intermediates] (not in PubMed) '''HAVE PDF''' | *2017: [https://pubs.rsc.org/en/content/articlehtml/2017/ra/c7ra09691g Structural insights into HIV-1 protease flap opening processes and key intermediates] (not in PubMed) '''HAVE PDF''' | ||
| + | This paper lists 3 "wide-open" crystal structures, all involving mutant HIV proteases: | ||
| + | <table> | ||
| + | <tr> | ||
| + | <td> | ||
| + | PDB ID | ||
| + | </td><td> | ||
| + | Year | ||
| + | </td><td> | ||
| + | Resolution | ||
| + | </td><td> | ||
| + | Asymm. Unit | ||
| + | </td><td> | ||
| + | I50 dist. | ||
| + | </td> | ||
| + | </tr><tr> | ||
| + | <td> | ||
| + | 1tw7 | ||
| + | </td><td> | ||
| + | 2005 | ||
| + | </td><td> | ||
| + | 1.3 Å | ||
| + | </td><td> | ||
| + | 2 chains | ||
| + | </td><td> | ||
| + | 12.3 Å | ||
| + | </td></tr></table> | ||
| + | |||
| + | |||
* I did not finish examining hits via google for 'hiv protease flaps animation' | * I did not finish examining hits via google for 'hiv protease flaps animation' | ||
Revision as of 18:10, 22 February 2020
- Rigidity 2012[1]
- Wide open[2]
- Course-grained[3]
- 2017: Structural insights into HIV-1 protease flap opening processes and key intermediates (not in PubMed) HAVE PDF
This paper lists 3 "wide-open" crystal structures, all involving mutant HIV proteases:
|
PDB ID |
Year |
Resolution |
Asymm. Unit |
I50 dist. |
|
1tw7 |
2005 |
1.3 Å |
2 chains |
12.3 Å |
- I did not finish examining hits via google for 'hiv protease flaps animation'
- Immunodeficiency virus protease includes morphs of flap movements and saquinavir binding. (HIV-1 protease redirects here.)
- Immunodeficiency virus protease 3D structures lists hundreds of crystal structures of HIV proteases.
- HIV Protease Inhibitor Resistance Profile
- Molecular Playground/HIV Protease Inhibitor includes an animated simulation of the protease inhibitor Ritonavir binding to the protease.
- Group:SMART:HIV-1 Subtype C Protease
- Protease
- Human Immunodeficiency Virus
- Journal:Acta_Cryst_D:S2059798319011355 Comparison of a retroviral protease crystallized as a monomer and a dimer.
- User:Tsung-Yi_Lin/Sandbox
- User:Dan_Huettner/Sandbox_1, User:Dan_Huettner/Sandbox_3
- User:David Canner/Sandbox HIV
- Sandbox 645
- Sandbox_Reserved_712
- Sandbox Reserved 955
- User:Nicole Maille/Sandbox 1
- ↑ Heal JW, Jimenez-Roldan JE, Wells SA, Freedman RB, Romer RA. Inhibition of HIV-1 protease: the rigidity perspective. Bioinformatics. 2012 Feb 1;28(3):350-7. doi: 10.1093/bioinformatics/btr683. PMID:22291339 doi:http://dx.doi.org/10.1093/bioinformatics/btr683
- ↑ Martin P, Vickrey JF, Proteasa G, Jimenez YL, Wawrzak Z, Winters MA, Merigan TC, Kovari LC. "Wide-open" 1.3 A structure of a multidrug-resistant HIV-1 protease as a drug target. Structure. 2005 Dec;13(12):1887-95. PMID:16338417 doi:10.1016/j.str.2005.11.005
- ↑ Tozzini V, Trylska J, Chang CE, McCammon JA. Flap opening dynamics in HIV-1 protease explored with a coarse-grained model. J Struct Biol. 2007 Mar;157(3):606-15. doi: 10.1016/j.jsb.2006.08.005. Epub 2006 , Aug 23. PMID:17029846 doi:http://dx.doi.org/10.1016/j.jsb.2006.08.005
