Flaps Morph for HIV Protease
From Proteopedia
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Mutations | Mutations | ||
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I10L, N25D, V36M, L46M, V54I, V62I, P63L, V71A, A82V, V84I, M90L | I10L, N25D, V36M, L46M, V54I, V62I, P63L, V71A, A82V, V84I, M90L | ||
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| + | [[3phv]] | ||
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K7Q | K7Q | ||
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K7Q, I33L, R41K, I63L | K7Q, I33L, R41K, I63L | ||
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</td></tr></table> | </td></tr></table> | ||
Revision as of 19:58, 22 February 2020
The genome of HIV codes for synthesis of a polyprotein that requires cutting by HIV protease in order to be separated into individual mature proteins required for virus maturation[1]. Drugs that inhibit HIV protease prevent the virus from replicating, and are crucial components of anti-HIV therapies.
The proteolytic active site of HIV protease is covered by two "flaps". It is believed that these flaps must open to enable substrate polyprotein to enter the active site. Mutations in HIV protease that confer resistance to inhibitor drugs often involve changes to the flaps[1].
- Rigidity 2012[2]
- Wide open[1]
- Course-grained[3]
- 2017: Structural insights into HIV-1 protease flap opening processes and key intermediates (not in PubMed) HAVE PDF
|
Wide-Open HIV Protease Crystal Structures |
||||||
|
PDB ID |
Year |
Resolution |
Asymm. Unit |
Ile50 dist. |
Mutations |
Wild Type |
|
1tw7 |
2005 |
1.3 Å |
2 chains |
12.25 Å |
I10L, N25D, V36M, L46M, V54I, V62I, P63L, V71A, A82V, V84I, M90L | |
|
2pc0 |
2007 |
1.4 Å |
1 chain |
12.2 Å |
K7Q | |
|
2r8n |
2008 |
1.2 Å |
1 chain |
12.19 Å |
K7Q, I33L, R41K, I63L | |
- I did not finish examining hits via google for 'hiv protease flaps animation'
- Immunodeficiency virus protease includes morphs of flap movements and saquinavir binding. (HIV-1 protease redirects here.)
- Immunodeficiency virus protease 3D structures lists hundreds of crystal structures of HIV proteases.
- HIV Protease Inhibitor Resistance Profile
- Molecular Playground/HIV Protease Inhibitor includes an animated simulation of the protease inhibitor Ritonavir binding to the protease.
- Group:SMART:HIV-1 Subtype C Protease
- Protease
- Human Immunodeficiency Virus
- Journal:Acta_Cryst_D:S2059798319011355 Comparison of a retroviral protease crystallized as a monomer and a dimer.
- User:Tsung-Yi_Lin/Sandbox
- User:Dan_Huettner/Sandbox_1, User:Dan_Huettner/Sandbox_3
- User:David Canner/Sandbox HIV
- Sandbox 645
- Sandbox_Reserved_712
- Sandbox Reserved 955
- User:Nicole Maille/Sandbox 1
- ↑ 1.0 1.1 1.2 Martin P, Vickrey JF, Proteasa G, Jimenez YL, Wawrzak Z, Winters MA, Merigan TC, Kovari LC. "Wide-open" 1.3 A structure of a multidrug-resistant HIV-1 protease as a drug target. Structure. 2005 Dec;13(12):1887-95. PMID:16338417 doi:10.1016/j.str.2005.11.005
- ↑ Heal JW, Jimenez-Roldan JE, Wells SA, Freedman RB, Romer RA. Inhibition of HIV-1 protease: the rigidity perspective. Bioinformatics. 2012 Feb 1;28(3):350-7. doi: 10.1093/bioinformatics/btr683. PMID:22291339 doi:http://dx.doi.org/10.1093/bioinformatics/btr683
- ↑ Tozzini V, Trylska J, Chang CE, McCammon JA. Flap opening dynamics in HIV-1 protease explored with a coarse-grained model. J Struct Biol. 2007 Mar;157(3):606-15. doi: 10.1016/j.jsb.2006.08.005. Epub 2006 , Aug 23. PMID:17029846 doi:http://dx.doi.org/10.1016/j.jsb.2006.08.005
