Flaps Morph for HIV Protease

From Proteopedia

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*Wide open<ref>PMID:16338417</ref>
*Wide open<ref>PMID:16338417</ref>
*Course-grained<ref>PMID:17029846 </ref>
*Course-grained<ref>PMID:17029846 </ref>
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*2017: [https://pubs.rsc.org/en/content/articlehtml/2017/ra/c7ra09691g Structural insights into HIV-1 protease flap opening processes and key intermediates] (not in PubMed)
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*2017: [https://pubs.rsc.org/en/content/articlehtml/2017/ra/c7ra09691g Structural insights into HIV-1 protease flap opening processes and key intermediates] (not in PubMed) '''HAVE PDF'''
* I did not finish examining hits via google for 'hiv protease flaps animation'
* I did not finish examining hits via google for 'hiv protease flaps animation'

Revision as of 17:34, 21 February 2020





  1. Heal JW, Jimenez-Roldan JE, Wells SA, Freedman RB, Romer RA. Inhibition of HIV-1 protease: the rigidity perspective. Bioinformatics. 2012 Feb 1;28(3):350-7. doi: 10.1093/bioinformatics/btr683. PMID:22291339 doi:http://dx.doi.org/10.1093/bioinformatics/btr683
  2. Martin P, Vickrey JF, Proteasa G, Jimenez YL, Wawrzak Z, Winters MA, Merigan TC, Kovari LC. "Wide-open" 1.3 A structure of a multidrug-resistant HIV-1 protease as a drug target. Structure. 2005 Dec;13(12):1887-95. PMID:16338417 doi:10.1016/j.str.2005.11.005
  3. Tozzini V, Trylska J, Chang CE, McCammon JA. Flap opening dynamics in HIV-1 protease explored with a coarse-grained model. J Struct Biol. 2007 Mar;157(3):606-15. doi: 10.1016/j.jsb.2006.08.005. Epub 2006 , Aug 23. PMID:17029846 doi:http://dx.doi.org/10.1016/j.jsb.2006.08.005

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Eric Martz

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