Flaps Morph for HIV Protease
From Proteopedia
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| - | The genome of HIV codes for synthesis of a polyprotein that requires cutting by HIV protease in order to | + | The genome of HIV codes for synthesis of a polyprotein that requires cutting by HIV protease in order to be separated into individual mature proteins required for virus maturation<ref name="wide-open" />. |
Revision as of 19:47, 22 February 2020
The genome of HIV codes for synthesis of a polyprotein that requires cutting by HIV protease in order to be separated into individual mature proteins required for virus maturation[1].
- Rigidity 2012[2]
- Wide open[1]
- Course-grained[3]
- 2017: Structural insights into HIV-1 protease flap opening processes and key intermediates (not in PubMed) HAVE PDF
|
Wide-Open HIV Protease Crystal Structures |
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|
PDB ID |
Year |
Resolution |
Asymm. Unit |
Ile50 dist. |
Mutations |
|
1tw7 |
2005 |
1.3 Å |
2 chains |
12.25 Å |
I10L, N25D, V36M, L46M, V54I, V62I, P63L, V71A, A82V, V84I, M90L |
|
2pc0 |
2007 |
1.4 Å |
1 chain |
12.2 Å |
K7Q |
|
2r8n |
2008 |
1.2 Å |
1 chain |
12.19 Å |
K7Q, I33L, R41K, I63L |
- I did not finish examining hits via google for 'hiv protease flaps animation'
- Immunodeficiency virus protease includes morphs of flap movements and saquinavir binding. (HIV-1 protease redirects here.)
- Immunodeficiency virus protease 3D structures lists hundreds of crystal structures of HIV proteases.
- HIV Protease Inhibitor Resistance Profile
- Molecular Playground/HIV Protease Inhibitor includes an animated simulation of the protease inhibitor Ritonavir binding to the protease.
- Group:SMART:HIV-1 Subtype C Protease
- Protease
- Human Immunodeficiency Virus
- Journal:Acta_Cryst_D:S2059798319011355 Comparison of a retroviral protease crystallized as a monomer and a dimer.
- User:Tsung-Yi_Lin/Sandbox
- User:Dan_Huettner/Sandbox_1, User:Dan_Huettner/Sandbox_3
- User:David Canner/Sandbox HIV
- Sandbox 645
- Sandbox_Reserved_712
- Sandbox Reserved 955
- User:Nicole Maille/Sandbox 1
- ↑ 1.0 1.1 Martin P, Vickrey JF, Proteasa G, Jimenez YL, Wawrzak Z, Winters MA, Merigan TC, Kovari LC. "Wide-open" 1.3 A structure of a multidrug-resistant HIV-1 protease as a drug target. Structure. 2005 Dec;13(12):1887-95. PMID:16338417 doi:10.1016/j.str.2005.11.005
- ↑ Heal JW, Jimenez-Roldan JE, Wells SA, Freedman RB, Romer RA. Inhibition of HIV-1 protease: the rigidity perspective. Bioinformatics. 2012 Feb 1;28(3):350-7. doi: 10.1093/bioinformatics/btr683. PMID:22291339 doi:http://dx.doi.org/10.1093/bioinformatics/btr683
- ↑ Tozzini V, Trylska J, Chang CE, McCammon JA. Flap opening dynamics in HIV-1 protease explored with a coarse-grained model. J Struct Biol. 2007 Mar;157(3):606-15. doi: 10.1016/j.jsb.2006.08.005. Epub 2006 , Aug 23. PMID:17029846 doi:http://dx.doi.org/10.1016/j.jsb.2006.08.005
