Hormones and their receptors
From Proteopedia
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=Steroid & thyroid hormones act via Intracellular receptors (nuclear receptors)= | =Steroid & thyroid hormones act via Intracellular receptors (nuclear receptors)= | ||
| - | For steroid or thyroid hormones, their receptors are located inside the cell within the cytoplasm of the target cell. These receptors belong to the nuclear receptor family of ligand-activated transcription factors. To bind their receptors, these hormones must first cross the cell membrane. They can do so because they are lipid-soluble. The combined hormone-receptor complex then moves across the nuclear membrane into the nucleus of the cell, where it binds to specific DNA sequences, regulating the expression of certain genes, and thereby increasing the levels of the proteins encoded by these genes. | + | For steroid or thyroid hormones, their receptors are located inside the cell within the cytoplasm of the target cell. These receptors belong to the nuclear receptor family of ligand-activated transcription factors. To bind their receptors, these hormones must first cross the cell membrane. They can do so because they are lipid-soluble. The combined hormone-receptor complex then moves across the nuclear membrane into the nucleus of the cell, where it binds to specific DNA sequences, regulating the expression of certain genes, and thereby increasing the levels of the proteins encoded by these genes. See also [[Steroid Hormones and their receptors]]. |
'''However, it has been shown that not all steroid receptors are located inside the cell. Some are associated with the plasma membrane.''' | '''However, it has been shown that not all steroid receptors are located inside the cell. Some are associated with the plasma membrane.''' | ||
Revision as of 12:47, 25 April 2023
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References
- ↑ Li MJ, Greenblatt HM, Dym O, Albeck S, Pais A, Gunanathan C, Milstein D, Degani H, Sussman JL. Structure of estradiol metal chelate and estrogen receptor complex: The basis for designing a new class of selective estrogen receptor modulators. J Med Chem. 2011 Apr 7. PMID:21473635 doi:10.1021/jm200192y
