Flaps Morph for HIV Protease

From Proteopedia

proteopedia linkproteopedia link

• Rigidity 2012^[1]
• Wide open^[2]

• Immunodeficiency virus protease
• Protease Comparison of a retroviral protease crystallized as a monomer and a dimer

• Journal:Acta_Cryst_D:S2059798319011355

• User:Tsung-Yi_Lin/Sandbox
• User:Dan_Huettner/Sandbox_1, User:Dan_Huettner/Sandbox_3
• User:David Canner/Sandbox HIV
• Sandbox 645
• Sandbox_Reserved_712
• Sandbox Reserved 955
• User:Nicole Maille/Sandbox 1

• Sandbox 215
• Fatty acid amide hydrolase, Sandbox_Reserved_921, Sandbox_Reserved_922

1. ↑ Heal JW, Jimenez-Roldan JE, Wells SA, Freedman RB, Romer RA. Inhibition of HIV-1 protease: the rigidity perspective. Bioinformatics. 2012 Feb 1;28(3):350-7. doi: 10.1093/bioinformatics/btr683. PMID:22291339 doi:http://dx.doi.org/10.1093/bioinformatics/btr683
2. ↑ Martin P, Vickrey JF, Proteasa G, Jimenez YL, Wawrzak Z, Winters MA, Merigan TC, Kovari LC. "Wide-open" 1.3 A structure of a multidrug-resistant HIV-1 protease as a drug target. Structure. 2005 Dec;13(12):1887-95. PMID:16338417 doi:10.1016/j.str.2005.11.005