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RNA polymerase 3D structures

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*''RNA-dependent RNAP complex with small molecule''
*''RNA-dependent RNAP complex with small molecule''
-
**[[2xwy]], [[3mf5]], [[3hkw]], [[3hky]], [[3lkh]], [[3gnv]], [[3gnw]], [[3h98]], [[3g86]], [[3h59]], [[1nhu]], [[1nhv]], [[2brk]], [[2brl]], [[2gc8]], [[2giq]], 2gir]], [[2hai]], [[2hwh]], [[2hwi]], [[2i1r]], [[2ijn]], [[2jc0]], [[2jc1]], [[2qe2]], [[2qe5]], [[2wcx]], [[2who]], [[3ciz]], [[3cj0]], [[3cj2]], [[3cj3]], [[3cj4]], [[3cj5]], [[3cso]], [[3cvk]], [[3fqk]], [[3fql]], [[3gol]], [[3h5s]], [[3h5u]], [[3q0z]], [[3qgd]], [[3qge]], [[3qgf]], [[3qgg]], [[3qgh]], [[3qgi]], [[3ska]], [[3ske]], [[3skh]], 3uph]], [[3upi]], [[4dru]], [[3vqs]], [[3udl]], [[4eo6]], [[4eo8]], [[4eaw]], [[4gmc]], [[4ih5]], [[4ih6]], [[4ih7]], [[4iz0]], [[4jtz]], [[4jtw]], [[4jty]], [[4ju1]], [[4ju2]], [[4jjs]], [[4jju]], [[4j02]], [[4j04]], [[4j06]], [[4j08]], [[2yoj]], [[3tuq]], [[3tuv]], [[3u4o]], [[3u4r]], [[4mk7]], [[4mk8]], [[4mk9]], [[4mka]], [[4mkb]], [[4mz4]], [[4nld]], [[3tyq]], [[3tyv]], [[4mia]], [[4mib]], [[4oow]], [[4tlr]], [[5pzk]], [[5pzl]], [[5pzm]], [[5pzn]], [[5pzo]], [[5pzp]], [[5trh]], [[5tri]], [[5trj]] - HvRNAP Ns5b domain + inhibitor<br />
+
**[[2xwy]], [[3mf5]], [[3hkw]], [[3hky]], [[3lkh]], [[3gnv]], [[3gnw]], [[3h98]], [[3g86]], [[3h59]], [[1nhu]], [[1nhv]], [[2brk]], [[2brl]], [[2gc8]], [[2giq]], [[2gir]], [[2hai]], [[2hwh]], [[2hwi]], [[2i1r]], [[2ijn]], [[2jc0]], [[2jc1]], [[2qe2]], [[2qe5]], [[2wcx]], [[2who]], [[3ciz]], [[3cj0]], [[3cj2]], [[3cj3]], [[3cj4]], [[3cj5]], [[3cso]], [[3cvk]], [[3fqk]], [[3fql]], [[3gol]], [[3h5s]], [[3h5u]], [[3q0z]], [[3qgd]], [[3qge]], [[3qgf]], [[3qgg]], [[3qgh]], [[3qgi]], [[3ska]], [[3ske]], [[3skh]], [[3uph]], [[3upi]], [[4dru]], [[3vqs]], [[3udl]], [[4eo6]], [[4eo8]], [[4eaw]], [[4gmc]], [[4ih5]], [[4ih6]], [[4ih7]], [[4iz0]], [[4jtz]], [[4jtw]], [[4jty]], [[4ju1]], [[4ju2]], [[4jjs]], [[4jju]], [[4j02]], [[4j04]], [[4j06]], [[4j08]], [[2yoj]], [[3tuq]], [[3tuv]], [[3u4o]], [[3u4r]], [[4mk7]], [[4mk8]], [[4mk9]], [[4mka]], [[4mkb]], [[4mz4]], [[4nld]], [[3tyq]], [[3tyv]], [[4mia]], [[4mib]], [[4oow]], [[4tlr]], [[5pzk]], [[5pzl]], [[5pzm]], [[5pzn]], [[5pzo]], [[5pzp]], [[5trh]], [[5tri]], [[5trj]] - HvRNAP Ns5b domain + inhibitor<br />
**[[3gyn]], [[1os5]], [[3br9]], [[3bsa]], [[3bsc]], [[3cde]], [[3co9]], [[3cwj]], [[3d28]], [[3d5m]], [[3e51]], [[3frz]], [[3igv]], [[3hvo]], [[3h2l]], [[4kai]], [[4kb7]], [[4kbi]], [[4ke5]], [[4khm]], [[4khr]], [[5twm]], [[5twn]] - HvRNAP Ns5b domain (mutant) + inhibitor<br />
**[[3gyn]], [[1os5]], [[3br9]], [[3bsa]], [[3bsc]], [[3cde]], [[3co9]], [[3cwj]], [[3d28]], [[3d5m]], [[3e51]], [[3frz]], [[3igv]], [[3hvo]], [[3h2l]], [[4kai]], [[4kb7]], [[4kbi]], [[4ke5]], [[4khm]], [[4khr]], [[5twm]], [[5twn]] - HvRNAP Ns5b domain (mutant) + inhibitor<br />
**[[2xi3]] - HvRNAP Ns5b domain (mutant) + GTP<br />
**[[2xi3]] - HvRNAP Ns5b domain (mutant) + GTP<br />

Revision as of 09:24, 13 November 2023

Updated on 13-November-2023 - For a general description of the protein see RNA polymerase {{#tree:id=OrganizedByTopic|openlevels=0|

  • Prokaryotic DNA-dependent RNAP
    • 2y0s – SsRNAP – Sulfolobus shibata
    • 1ryq - PfRNAP subunit ε - Pyrococcus furiosus
    • 1go3 – MjRNAP subunit RPB4, RPB7 - Methanocaldococcus jannaschii
    • 1iw7, 1smy, 6asg - TtRNAP subunits α,β,β',ω Thermus thermophilus
    • 8hsh - TtRNAP subunits α,β,β',ω - Cryo EM
    • 1doq - TtRNAP subunit α
    • 3lti– EcRNAP subunit β fragment – Escherichia coli
    • 4iqz - EcRNAP subunit β’
    • 3k4g, 1coo - EcRNAP subunit α
    • 1bdf - EcRNAP subunit α mutant)
    • 3lu0 - EcRNAP subunits α,β,β',ω – Electron diffraction
    • 2krc - BsRNAP subunit δ N-terminal – Bacillus subtilis – NMR
    • 2ly7 - BsRNAP subunit β NMR
    • 2m4k - BsRNAP subunit δ NMR
    • 4nc7, 4nc8 - BsRNAP subunit δ
    • 2max - HpRNAP subunit α - Helicobacter pylori - NMR
    • 1qyp – RNAP II C terminal – Thermococcus celer – NMR
    • 4kbj – MtuRNAP β subunit – Mycobacterium tuberculosis
    • 5uh7 - MtuRNAP subunit β’
    • 7z8q - MtuRNAP subunits α,β,β’,ω – Cryo EM
    • 4noi – RNAP α subunit – Campylobacter jejuni
    • 1hqm – TaRNAP subunits α,β,β',ω Thermus aquaticus
    • 2gho - TaRNAP subunits α,β,β'
    • 2auj, 2auk - TaRNAP subunit β’
    • 1xpp – RNAP subunit L – Thermoplasma acidophilum
    • 2waq, 2wb1, 4ayb – SsRNAP
    • 3e7h – VcRNAP subunit – Vibrio cholera
    • 1ef4 – MtRNAP subunit RPB10 – Methanothermobacter thermautotrophicus
    • 1eik - MtRNAP subunit RPB5 – NMR
    • 4qiw – TkRNAP subunits a’’+d+e’+f+h+k+l+n+p – Thermococcus kodakarensis
    • 6kf3 – TkRNAP subunits a’’+d+e’+f+h+k+l+n+p – Cryo EM
    • 4qjf - TkRNAP subunits e’+f
    • 4qjv - TkRNAP subunits d+l
    • 6eyd, 6f6w – MsRNAP subunits α,β,β',ω - Mycobacterium smegmatis – Cryo EM
    • 6vr4 – RNAP – Cellulophaga phage φ
    • 7ccg - RNAP subunit δ - Streptomyces albulus
    • 7ok0, 7oqy – SaRNAP – Sulfolobus acidocaldarius – Cryo EM
    • 8h02 – SeRNAP subunit ’ – Synechococcus elongatus
    • 8emb – RNAP subunit ’ si3 domain – Thermosynechococcus vestitus
    • 8dkc – RNAP subunits ’ Porphyromonas gingivalis – Cryo EM
  • Prokaryotic DNA-dependent RNAP complex with DNA/RNA or elongation complex
  • Prokaryotic DNA-dependent RNAP complex with protein
    • 3p8b – PfRNAP subunit ε’’ + NusG
    • 3qqc - PfRNAP subunits β, ε’’ + NusG
    • 2be5- TtRNAP subunits α,β,β’,ω + σ factor + inhibitor
    • 2cw0, 5tmf - TtRNAP subunits α,β,β’,ω + σ factor
    • 3wod - TtRNAP subunits α,β,β’,ω + σ factor + GP39
    • 4mq9 - TtRNAP subunits α,β,β’,ω + σ factor + GE23077
    • 5tmc - TtRNAP subunits α,β,β’,ω + σ factor + protein
    • 3dxj, 3eql - TtRNAP subunits α,β,β’,ω + σ factor + antibiotic
    • 5xj0 - TtRNAP subunits α,β,β’,ω + σ factor + GP39 + GP76
    • 4wqt - TtRNAP subunits α,β,β’,ω + RNA cleavage stimulating factor
    • 8hsl - TtRNAP subunits α,β,β’,ω + transcription termination factor rho – Cryo EM
    • 3mlq - TtRNAP subunit β + transcription-repair coupling factor
    • 3woe, 3wof - TtRNAP subunit β + GP39
    • 2lmc - EcRNAP subunit β + RNAP inhibitor
    • 3mmp - EcRNAP subunit β + EF-TU
    • 7egs - EcRNAP subunit β + DNA helicase II 654-720
    • 4ljz, 4lk1, 4mey, 4xsx, 4xsy, 4xsz, 4zh2, 4zh3 , 4zh4, 5byh, 5nwt, 5uag, 5uah, 5uaj, 5ual, 5uaq, 5ui8 - EcRNAP subunits α,β,β’,ω + σ factor
    • 6c9y - EcRNAP subunits α,β,β’,ω + σ factor – Cryo EM
    • 4mex - EcRNAP subunits α,β,β’,ω + σ factor + salinamide
    • 4lk0, 4llg, 4mex, 4yfk, 4yfn, 4yfx - EcRNAP subunits α,β,β’,ω + σ factor + RNAP inhibitor
    • 5uac, 6cux - EcRNAP subunits α,β,β’,ω + σ factor + antibiotic
    • 6byu - EcRNAP subunits α,β,β’,ω + σ factor + PPAPP
    • 5w1s - EcRNAP subunits α,β,β’,ω + σ factor + TRAR
    • 6p1k - EcRNAP subunits α,β,β’,ω + RPOD – Cryo EM
    • 7xui – EcRNAP in elongation complex + RPOD – Cryo EM
    • 6vjs - EcRNAP subunits α,β,β’,ω + RPOD + inhibitor
    • 6r9b, 6r9g - EcRNAP subunits α,β,β’,ω + OCR – Cryo EM
    • 6n57, 6n58 - EcRNAP subunits α,β,β’,ω + RPOD + TRAR – Cryo EM
    • 7w5y - EcRNAP subunits α,β,β’,ω + RPOD + SoxS – Cryo EM
    • 7w5w - EcRNAP subunits α,β,β’,ω + RPOD + SoxS + micF DNA – Cryo EM
    • 7w5x - EcRNAP subunits α,β,β’,ω + RPOD + SoxS + zwf DNA – Cryo EM
    • 5tbz - EcRNAP subunits α,β,β’ + NusG – Cryo EM
    • 6xln, 7mko - EcRNAP in elongation complex – Cryo EM
    • 7mkp - EcRNAP core – Cryo EM
    • 7m8e, 7mkn, 7mkq - EcRNAP subunits α,β,β’,ω + RapA – Cryo EM
    • 6fbv - MtuRNAP subunits α,β,β’,ω + σ factor – single particle EM
    • 7u22 - MtuRNAP subunits α,β,β’,ω + σ factor SIGA
    • 7pp4, 7q4u, 7q59, 7zf2 - MtuRNAP subunits α,β,β’,ω + σ factor SIGB – Cryo EM
    • 5zx3 - MtuRNAP subunits α,β,β’,ω + σ factor SIGH
    • 3ihq, 1z3e, 3gfk - BsRNAP subunit α + regulatory protein SPX
    • 1l9u - TaRNAP subunits α,β,β’,ω + σ factor
    • 2jzb – RNAP subunit α + NusA – Yersinia pseudotuberculosis
    • 3tbi - RNAP subunit β + GP33 – Enterobacteria phage T4
    • 3lpe - MjRNAP subunit ε’’ + NusG
    • 6eyd - MsRNAP subunits α,β,β’,ω + σ factor – Cryo EM
    • 6yxu, 6yys, 6z11 - MsRNAP subunits α,β,β’,ω + HelD – Cryo EM
    • 6kf4 – TkRNAP subunits a’+d+e’+f+h+k+l+n+p + transcription factor E – Cryo EM
    • 6wvk, 6zca, 6zfb - BsRNAP subunits α,β,β’,d + HelD – Cryo EM
    • 7oq4 - SaRNAP + viral RNAP inhibitory protein – Cryo EM
  • Prokaryotic DNA-dependent RNAP complex with σ factor + DNA/RNA
    • 6lts - TtRNAP subunits α,β,β’,ω + σ factor SIGA + DNA
    • 7qxi - TtRNAP subunits α,β,β’,ω + σ factor-54 + DNA – Cryo EM
    • 7mlb, 7mli, 7mlj, 7rdq - TtRNAP in elongation complex + σ factor SIGA – Cryo EM
    • 4oin, 4oio - TtRNAP subunits α,β,β’,ω + σ factor + GE23077 + DNA
    • 4oip - TtRNAP subunits α,β,β’,ω + σ factor + GE23077 + DNA + nucleotide
    • 4oiq, 4oir - TtRNAP subunits α,β,β’,ω + σ factor + GE23077 + DNA + antibiotic
    • 4g7h, 4g7o, 4g7z, 4q4z, 5d4d, 5d4e, 5voi, 6p70 - TtRNAP subunits α,β,β’,ω + σ factor + DNA
    • 4q5s, 5d4c, 5e17, 5e18, 5vo8, 6p71, 6oy7, 6oy6, 6oy5, 6ow3, 6ovy, 6ovr, 6kqd, 6kqe, 6kqf, 6kqg, 6kqh, 6kql, 6kqm, 6kqn, 6l74 - TtRNAP in elongation complex
    • 5i2d - TtRNAP subunits α,β,β’,ω + σ factor + transcriptional regulator + DNA + RNA
    • 6cuu - TtRNAP subunits α,β,β’,ω + σ factor + DNA + antibiotic
    • 6n62 - EcRNAP subunits α,β,β’,ω + σ factor + DNA
    • 6n61 - EcRNAP subunits α,β,β’,ω + σ factor + DNA + capistruin peptide
    • 6n60 - EcRNAP subunits α,β,β’,ω + σ factor + DNA + microcin peptide
    • 5nsr, 5nss, 6gh6, 6gh5, 6ca0, 6omf, 7mkd, 7mke, 7mki, 7mkj - EcRNAP subunits α,β,β’,ω + σ factor + DNA – Cryo EM
    • 5vt0 - EcRNAP subunits α,β,β’,ω + σ factor + RNA – Cryo EM
    • 4yln, 4ylo, 4ylp, 5ipl, 5ipm, 5ipn, 6gfw - EcRNAP subunits α,β,β’,ω + σ factor + DNA + RNA
    • 6b6h - EcRNAP subunits α,β,β’,ω + σ factor + CAP + DNA + RNA – Cryo EM
    • 8hkc - EcRNAP subunits α,β,β’ + σ factor RPOH + DNA – Cryo EM
    • 6k4y - EcRNAP subunits α,β,β’,ω + σ factor + MTOH + DNA – Cryo EM
    • 7qwp, 8f1j - EcRNAP subunits α,β,β’,ω + σ factor-54 + DNA – Cryo EM
    • 7q9v - EcRNAP subunits α,β,β’,ω + σ factor-54 + PspF + DNA – Cryo EM
    • 3iyd - EcRNAP subunits α,β,β’,ω + σ factor + catabolite gene activator + DNA
    • 4s20 - EcRNAP subunits α,β,β’,ω + σ factor + RAPA + DNA
    • 5ms0 - EcRNAP subunits α,β,β’,ω + σ factor + NusB + NusG + NusA + RS10 + DNA – Cryo EM
    • 5uha, 6vw0, 7rwi - MtuRNAP subunits α,β,β’,ω + σ factor + DNA
    • 5uh9, 5uh8, 6jcy, 6jcx, 6jbq, 6kon, 6koo, 6kop, 6koq, 6tye, 6tyf, 6tyg - MtuRNAP subunits α,β,β’,ω + σ factor + DNA + RNA
    • 8e8m, 8e95 - MtuRNAP in elongation complex
    • 8hih - MtuRNAP in elongation complex + GlnR – Cryo EM
    • 5uhg, 5uhc, 5uh6, 5uh5 - MtuRNAP subunits α,β,β’,ω + σ factor + DNA + RNA + antibiotic
    • 5uhd, 5uhb - MtuRNAP subunits α,β,β’,ω + σ factor + DNA + antibiotic
    • 5uhf, 5uhe - MtuRNAP subunits α,β,β’,ω + σ factor + DNA + RNA + inhibitor
    • 1l9z - TaRNAP subunits α,β,β’,ω + σ factor + DNA
    • 8i23, 8i24 - RNAP subunits α,β,β’,ω + σ factor SIGI1 + DNA – Clostridium thermocellum - Cryo EM
  • Prokaryotic DNA-dependent RNAP complex with protein + DNA/RNA
    • 3aoh, 3aoi - TtRNAP subunits α,β,β’,ω + DNA + RNA + GFH1
    • 6wox, 6woy, 7eh0, 7eh1, 7eh2 - TtRNAP subunits α,β,β’,ω in transcription complex
    • 6m6a, 6m6b - TtRNAP subunits α,β,β’,ω + transcription-repair-coupling factor + DNA – Cryo EM
    • 3t72 - EcRNAP subunit β + Pho box DNA + PhoB
    • 1lb2, 3n4m - EcRNAP subunit α + DNA + CAP
    • 1xs9 - EcRNAP subunit α + DNA + MARA
    • 5ciz - EcRNAP subunit α + DNA + CRP
    • 3n97 - EcRNAP subunit α C terminal + DNA + σ factor
    • 6z9p, 6z9q, 6z9r, 6z9s, 6z9t, 7add, 7ade - EcRNAP in termination transcription complex
    • 6vyu - EcRNAP in transcription initiation complex + mRNA
    • 6c6u - EcRNAP subunits α,β,β’,ω + NusG + DNA – Cryo EM
    • 6vu3, 6vz3 - EcRNAP transcription translation complex + mRNA – Cryo EM
    • 6vzj - EcRNAP transcription translation complex + mRNA + tRNA – Cryo EM
    • 6vyz - EcRNAP transcription translation complex + NusA + mRNA + tRNA – Cryo EM
    • 6vyq, 6vyr, 6vys, 6vyt, 6vyw, 6vyx, 6vyy, 6vz2, 6vz5, 6vz7, 6xdr, 6xgf, 6xij, 6xii - EcRNAP transcription translation complex + NusG + mRNA + tRNA – Cryo EM
    • 6x6t, 6x7f, 6x7k, 6x9q, 6xdq - EcRNAP transcription translation complex + NusA + NusG + mRNA + tRNA – Cryo EM
    • 6c6t, 6c6s - EcRNAP subunits α,β,β’,ω + RFAH + DNA – Cryo EM
    • 6gov - EcRNAP subunits α,β,β’,ω + NusB + NusG + RS10 + DNA – Cryo EM
    • 6flq - EcRNAP subunits α,β,β’,ω + NusA + DNA + RNA – Cryo EM
    • 6xas - EcRNAP subunits α,β,β’,ω + NusA + helicase rho + DNA + RNA – Cryo EM
    • 6xav, 7adb, 7adc - EcRNAP subunits α,β,β’,ω + NusG + helicase rho + DNA + RNA – Cryo EM
    • 6alg - EcRNAP subunits α,β,β’,ω + NUN + DNA + RNA – Cryo EM
    • 6p19 - EcRNAP subunits α,β,β’,ω + protein Q + DNA + RNA – Cryo EM
    • 6jnx - EcRNAP subunits α,β,β’,ω + protein Q + σ factor + DNA – Cryo EM
    • 6p18 - EcRNAP subunits α,β,β’,ω + protein Q + σ factor + DNA + RNA – Cryo EM
    • 6kj6 - EcRNAP subunits α,β,β’,ω + RPOS + σ factor-binding protein CRL + DNA + RNA – Cryo EM
    • 7chw, 8igs - EcRNAP subunits α,β,β’,ω + σ factor-binding protein PROD + DNA – Cryo EM
    • 6x26, 6x2f, 6x2n, 6x43, 6x4w, 6x4y, 6x50 - EcRNAP in elongation complex + TRCF – Cryo EM
    • 8e3f, 8e6x, 8e6z - EcRNAP in elongation complex + NusG - Cryo EM
    • 8g4w, 8g8z - EcRNAP in elongation complex + preQ1 – Cryo EM
    • 7uwe - EcRNAP in elongation complex + RNase HII – Cryo EM
    • 8igr - EcRNAP in transcription activation complex + phage regulatory protein CII - Cryo EM
    • 7vwz - EcRNAP in transcription activation complex + NusA + antitermination protein - Cryo EM
    • 7ubm, 7ubn - EcRNAP in transcription antitermination complex + right origin binding protein - Cryo EM
    • 7khb, 7khc, 7khe, 7khi - EcRNAP subunits α,β,β’,ω + σ factor RPOD + DNAK suppressor protein + DNA – Cryo EM
    • 7bef, 7beg - EcRNAP subunits α,β,β’,ω + σ factor RPOD + RAMA + DNA – Cryo EM
    • 6xh7, 7c17 - EcRNAP subunits α,β,β’,ω + σ factor RPOD + CueR + DNA – Cryo EM
    • 6xh8 - EcRNAP subunits α,β,β’,ω + σ factor RPOD + CueR + DNA + RNA – Cryo EM
    • 6xl5, 6xl9, 6xlj, 6xll, 6xlm - EcRNAP subunits α,β,β’,ω + σ factor RPOD + DNA + RNA – Cryo EM
    • 6wmu, 7c97, 7dy6 - EcRNAP subunits α,β,β’,ω + σ factor RPOD + starvation protein + DNA - Cryo EM
    • 7d7c - EcRNAP subunits α,β,β’,ω + GP55 + DNA - Cryo EM
    • 7d7d - EcRNAP subunits α,β,β’,ω + DNAP clamp + GP55 + DNA - Cryo EM
    • 6n4c, 6oul, 6wr6, 6wr8, 7n4e - EcRNAP subunits α,β,β’,ω + RPOD + DNA – Cryo EM
    • 7szj, 7szk - EcRNAP subunits α,β,β’,ω + RPOD + DNA + drug – Cryo EM
    • 6ldi - EcRNAP subunits α,β,β’,ω + RPOD + CUER + DNA + RNA – Cryo EM
    • 6pb4, 6pb5, 6pb6 - EcRNAP subunits α,β,β’,ω + RPOD + CRP + DNA + RNA – Cryo EM
    • 6psq, 6psr, 6pss, 6pst, 6psu, 6psv, 6psw - EcRNAP subunits α,β,β’,ω + RPOD + TRAR + DNA + RNA – Cryo EM
    • 6pmi, 6pmj - EcRNAP subunits α,β,β’,ω + FLIA + DNA + RNA – Cryo EM
    • 6rin, 6ri7 - EcRNAP subunits α,β,β’,ω + GREB + RNA + DNA – Cryo EM
    • 6tqn, 6tqo - EcRNAP subunits α,β,β’,ω in anti-termination complex – Cryo EM
    • 7c17 - EcRNAP subunits α,β,β’,ω in transcription complex – Cryo EM
    • 7py3, 7pyj, 7pyk - EcRNAP in elongation complex + NusA - Cryo EM
    • 7py0, 7py1, 7py8 - EcRNAP in elongation complex + NusG - Cryo EM
    • 7py5, 7py6, 7py7 - EcRNAP in elongation complex + NusG + NusA - Cryo EM
    • 8e5k, 8e5o - EcRNAP in transcription pre-termination complex + NusG - Cryo EM
    • 7c97, 7chw - EcRNAP subunits α,β,β’,ω in promoter-open complex – Cryo EM
    • 6j9f - XoRNAP subunits α,β,β’,ω + P7 + DNA + RNA – Xanthomonas oryzae - Cryo EM
    • 6j9e - XoRNAP subunits α,β,β’,ω + P7 + DNA + RNA + NusA - Cryo EM
    • 6kf9 – TkRNAP subunits a’’+d+e’+f+h+k+l+n+p + transcription factor E + DNA – Cryo EM
    • 6dve, 6dvd, 6dvc, 6dvb, 6dv9 - MtuRNAP subunits α,β,β’,ω + σ factor + DNA
    • 5zx2 - MtuRNAP subunits α,β,β’,ω + σ factor + DNA + RNA
    • 7kin - MtuRNAP subunits α,β,β’,ω + σ factor + DNA + RBPA – Cryo EM
    • 7kif, 7kim - MtuRNAP subunits α,β,β’,ω + σ factor + DNA + RBPA + CARD + Whib7 – Cryo EM
    • 6wmp - FtRNAP subunits α,β,β’,ω + RNA + DNA – Francisella tularensis - Cryo EM
    • 6wmr, 6wmt - FtRNAP subunits α,β,β’,ω + σ factor-binding protein PROD + starvation protein + macrophage growth locus + DNA - Cryo EM
    • 6wvj - BsRNAP in elongation complex - Cryo EM
    • 7ckq - BsRNAP subunits α,β,β’,ω + σ factor-binding protein SIGA + multidrug regulator + YkzG + DNA - Cryo EM
    • 7f75 - BsRNAP subunits α,β,β’,ω + σ factor-binding protein SIGA + regulator Spx + RNA + DNA - Cryo EM
    • 7ye2 - CavRNAP in transcription activation complex – Caulobacter vibrioides - Cryo EM
    • 7ye1 - CavRNAP in transcription activation complex + GCRA - Cryo EM
    • 7xya, 7xyb – PaRNAP subunits α,β,β’,ω + AlpA peptide + RNA + DNA – Pseudomonas aeruginosa
    • 7xyb – PaRNAP subunits α,β,β’,ω + sigma factor RPOS – Cryo EM
    • 7f0r, 7xl3, 7xl4 – PaRNAP subunits α,β,β’,ω + sigma factor RPOS + SutA – Cryo EM
    • 8e79 - BsRNAP in elongation complex + NusG - Cryo EM
    • 8e74, 8e82, 8ehq, 8ej3, 8eoe, 8eof, 8eos, 8eot, 8exy - MtuRNAP in elongation complex + NusG - Cryo EM
    • 8h3v - RNAP in transcription activation complex + NusG + NTCA + NTCB + VF1- Cryo EM
    • 8dy7, 8dy9 - RNAP subunits α,β,β’,ω + σ factor + DNA + RBPA + WHIA + WHIB – Streptococcus venezuelae - Cryo EM
    • 8syi - SeRNAP in elongation complex + NusG - Cryo EM
    • 7vpd, 7vpz, 7x74, 7x75, 7x76 - RNAP in elongation complex + ZUR – Streptococcus coelicolor - Cryo EM
  • Prokaryotic DNA-dependent RNAP complex with small molecule
  • Viral DNA-dependent RNAP
    • 6ric, 7amv, 7aoz, 7ap8, 7ap9, 7aof, 7aoh – VvRNAP – vaccinia virus – Cryo EM
    • 6rid – VvRNAP + RNA + DNA – Cryo EM
    • 6rie – VvRNAP + mRNA capping enzyme + RNA + DNA – Cryo EM
    • 8fm9, 8fma, 8fmb – RNAP – flock house virus – Cryo EM
  • Eukaryotic DNA-dependent RNAP I
    • 8a43 – hRNAP I – human - Cryo EM
    • 7oba – hRNAP I + TIF-IA - Cryo EM
    • 7obb – hRNAP I + DNA – Cryo EM
    • 7ob9, 7vba, 7vbb, 7vbc – hRNAP I in elongation complex – Cryo EM
    • 1a1d – yRNAP subunit RPB8 – yeast - NMR
    • 2rf4 - yRNAP I subunit RPA4
    • 5g5l, 5lmx, 5m3f, 5m3m, 5m5w, 5m5x, 5m5y, 5m64 – yRNAP I – Cryo EM
    • 5n5y, 5n5z, 5n60, 5oa1 – yRNAP I + RRN – Cryo EM
    • 5n61, 6h68, 6h67 – yRNAP I + RRN + DNA + RNA – Cryo EM
    • 5w66, 5w65, 5w64, 5w5y – yRNAP I + transcription initiation factor + DNA + RNA – Cryo EM
    • 6tps – yRNAP I in pre-initiation complex – Cryo EM
    • 7aoc, 7aod, 7aoe – fyRNAP I – fission yeast – Cryo EM
  • Eukaryotic DNA-dependent RNAP II
  • Eukaryotic DNA-dependent RNAP II complex with DNA/RNA
  • Eukaryotic DNA-dependent RNAP II complex with protein
    • 3o2q, 3o2s – hRNAP II subunit α C-terminal + symplekin
    • 3j0k, 5iy6, 5iy7, 5iy8, 5iy9, 5iya, 5iyb, 5iyc, 5iyd – hRNAP II + TFIIF – Cryo EM
    • 7dti – hRNAP II subunit RPB6 + TFIIH – NMR
    • 6xre – hRNAP II + p53 – Cryo EM
    • 2lto - hRNAP II subunit RPB1 + Tudor domain containing protein 3
    • 8jal, 8jaq, 8jar, 8jas, 8jau, 8jav – hRNAP II in cullin-RING E3 ubiquitin ligase – Cryo EM
    • 7xt7, 7xtd, 7xti – hRNAP II in elongation complex + nucleosome – Cryo EM
    • 8bvw, 8byq – hRNAP II in pre-initiation complex + nucleosome – Cryo EM
    • 8p4f – hRNAP II in co-transcriptional capping complex – Cryo EM
    • 7nvu, 7nvt, 7nvu - pRNAP II + DNA + TFIIA + TFIIF + TATA-box-binding protein – pig - Cryo EM
    • 7edx, 7eg7, 7eg8, 7eg9, 7ega, 7egb, 7egc - pRNAP II + DNA + TFIIA + TFIIB + TFIIE + TFIIF + TATA-box-binding protein - Cryo EM
    • 7nw0 - pRNAP II + DNA + TFIIB + TFIIH + MAT1 + TATA-box-binding protein - Cryo EM
    • 8a40 - pRNAP II in elongation complex + TFIIS - Cryo EM
    • 7und – pRNAP II + nucleosome – Cryo EM
    • 7okx, 7oky – pRNAP II + RNA + DNA + SPT5 + ELL2 – Cryo EM
    • 7ol0 – pRNAP II + RNA + DNA + SPT5 – Cryo EM
    • 7oo3 – pRNAP II + RNA + CSA + CSB + DDB1 + UVSSA – Cryo EM
    • 7oop, 7opc, 7opd – pRNAP II + RNA + CSA + CSB + DDB1 + UVSSA – Cryo EM
    • 7oob – pRNAP II + RNA + CSA + CSB + SPT6 + UVSSA + PAF – Cryo EM
    • 6gml – pRNAP II + RNA + DNA + DSIF + NELF – Cryo EM
    • 6gmh, 6ted – pRNAP II + RNA + DNA + DSIF + PAF + SPT6 – Cryo EM
    • 6exv – pRNAP II + RNA + DNA + amatoxin – Cryo EM
    • 8oew – pRNAP II + RNA + DNA + elongin A,B,C – Cryo EM
    • 8oeu – pRNAP II + RNA + DNA + SPT6 – Cryo EM
    • 8oev, 8of0 – pRNAP II + RNA + DNA + elongin A,B,C + SPT6 – Cryo EM
    • 8p4b, 8p4c – pRNAP II in co-transcriptional capping complex – Cryo EM
    • 7b7u, 7f4g – pRNAP II + hRPAP2 – Cryo EM
    • 7nvs, 7nvy, 7nvz – pRNAP II in pre-initiation complex – Cryo EM
    • 7nvr – pRNAP II in pre-initiation complex + hmediator – Cryo EM
    • 7b0y – pRNAP II in transcription complex + U1 SNRNP – Cryo EM
    • 1pqv, 1y1v, 4bbr, 4bbs - yRNAP II + TFIIS
    • 1y1y - yRNAP II + TFIIS + DNA +RNA
    • 1r5u, 3k7a, 3k1f - yRNAP II + TFIIB
    • 7mk9 - yRNAP II + DNA + TIIF – Cryo EM
    • 4v1o, 5fyw, 5fz5, 5sva - yRNAP II + DNA + TIIF + TBP + mediator – Cryo EM
    • 2l0i – yRNAP C-terminal + RTT103 – NMR
    • 4bxx, 4bxz, 4by1, 4by7 – yRNAP II + RNA + DNA + transcription factor Bye1
    • 5vvr - yRNAP II + DNA + RNA + Rad26 – Cryo EM
    • 6upx, 6upy, 6upz, 6uq0, 6uq1, 6uq2, 6uq3, 7rim, 7rip, 7riq 7riw, 7rix, 7riy - yRNAP II in elongation complex
    • 6a5v, 6a5u, 6a5t, 6a5r, 6a5p, 6a5o, 6a5l, 7nkx, 7nky – yRNAP II + DNA + RNA + nucleosome – Cryo EM
    • 7ml0, 7ml1, 7ml2, 7ml4, 7o4i, 7o4j, 7o4k, 7o4l, 7o72, 7o73, 7o75 - yRNAP II + DNA + TFIIH + TBP – Cryo EM
    • 7kpv – yRNAP II cyclin-like subunit in Cdk8 kinase module – Cryo EM
    • 8cen – yRNAP II in pre-initiation complex + mediator – Cryo EM
    • 7zs9, 7zsa, 7zsb – yRNAP II in pre-initiation complex + nucleosome – Cryo EM
    • 8ceo – yRNAP II in pre-initiation complex + nucleosome + mediator – Cryo EM
    • 8h0v, 8h0w – KpRNAP II in chromatosome – Komagataella phaffii - Cryo EM
    • 7xse, 7xsx, 7xsz – KpRNAP II in elongation complex + nucleosome - Cryo EM
    • 8he5 – KpRNAP II in elongation complex + nucleosome + Rad26 + Elf1- Cryo EM
    • 7wbv, 7wbw, 7wbx – KpRNAP II in elongation complex + Elf1 + Spt4/5 - Cryo EM
    • 7xn7 – KpRNAP II in elongation complex + Elf1 + Spt4/5 + Spt6 + Spn1 + Paf1C - Cryo EM
  • Eukaryotic DNA-dependent RNAP II complex with small molecule
  • Eukaryotic DNA-dependent RNAP III
    • 7a6h, 7ae1, 7ae3, 7aea, 7ast, 7d58, 7d59, 7dn3, 7du2, 7fji, 7fjj - hRNAP III – Cryo EM
    • 8ity, 8iuh - hRNAP III in pre-initiation complex – Cryo EM
    • 2xub, 2xv4 - hRNAP III subunit Rpc3
    • 5afq - hRNAP III subunits Rpc3 + Rpc32B
    • 7asu, 7asv - hRNAP III subunit Rpc5
    • 2dk5 – hRNAP III winged helix domain (mutant) – NMR
    • 2yu3 - hRNAP III winged helix domain
    • 2dk8 – RNAP III RPC34 domain - mouse – NMR
    • 2ckz, 5fj9, 5fja, 6eu3, 6eu2 - yRNAP III - Cryo EM
    • 5fj8, 6f41, 7z1m, 7z1n, 7z1o, 8bws - yRNAP III in elongation complex - Cryo EM
    • 6f44, 6f42, 6f40, 6eu1 - yRNAP III + DNA – Cryo EM
    • 6cnf, 6cnd, 6cnc, 6cnb - yRNAP III + DNA + TFIIIB – Cryo EM
    • 5xon - yRNAP III + DNA + RNA + TFIIB + SPT4 + SPT5 – Cryo EM
    • 5xog - yRNAP III + DNA + RNA + SPT5 + KOW5 + ELF1 – Cryo EM
    • 6eu0 - yRNAP III + DNA + TFIIIB + TATA-box-binding protein – Cryo EM
    • 6tut - yRNAP III complex + MAF1 – Cryo EM
    • 7z0h, 7z2z, 7z30, 7z31 - yRNAP III complex + Ty1 integrase – Cryo EM
    • 7z1l - yRNAP III pre-termination complex – Cryo EM
    • 3ayh - fyRNAP III subunit Rpc8+Rpc9
  • Eukaryotic DNA-dependent RNAP I+II+III
  • Eukaryotic DNA-dependent RNAP IV
  • Eukaryotic DNA-dependent RNAP V
    • 8hyj - AtRNAP + KTF1 - Cryo EM
  • Eukaryotic DNA-dependent RNAP I+II+III+IV+V
    • 8hil, 8him - RNAP in elongation complex – cabbage - Cryo EM
  • Eukaryotic DNA-dependent RNAP μ or DNA-directed DNA/RNA polymerase mu
  • Eukaryotic DNA-dependent RNAP mitochondrial or MTRPOL
    • 7pzp, 7pzr – hRNAP – Cryo EM
    • 4boc – hRNAP + DNA
    • 6erq, 6erp – hRNAP + DNA + MTTFA + dimethyladenosine transferase
    • 3spa - hRNAP + polypeptide
    • 7a8p - hRNAP + inhibitor
    • 8att, 8atv, 8atw, 8c5s, 8c5u, 8q63 – yRNAP in transcription initiation complex + RNA – Cryo EM
    • 8ap1 – yRNAP in transcription initiation complex + GTP – Cryo EM


  • Eukaryotic DNA primase
    • 4lik, 4mhq, 6rb4 - hDNAP small subunit
    • 3q36 – hDNAP large subunit
    • 5i7m – hDNAP large subunit (mutant)
    • 3l9q – hDNAP large subunit P58C domain
    • 5dqo – hDNAP large subunit P58C domain (mutant)
    • 4rr2 - hDNAP small + large subunit
    • 4bpu - hDNAP small (mutant) + large subunit
    • 4ehs – HpDNAP C terminal
    • 4lim, 4mm2 - yDNAP small subunit
    • 3lgb, 6di6, 6dhw - yDNAP large subunit Fe-S domain
    • 6du0, 6dtz, 6dtv, 6di2 - yDNAP large subunit Fe-S domain (mutant)
    • 7tl2 - yDNAP large subunit C-terminal domain (mutant)
  • Eukaryotic DNA primase complex
    • 4lil - hDNAP small subunit + UTP
    • 6r4s - hDNAP small subunit + ATP
    • 6r5e, 6r5d, 6r4u, 6r4t - hDNAP small subunit + nucleoside analog
    • 5f0s, 5f0q – hDNAP large subunit C terminal + RNA
    • 4bpw - hDNAP small (mutant) + large subunit + UTP
    • 4bpx - hDNAP small (mutant) + DNA polymerase α catalytic subunit
    • 5exr - hDNAP small + large subunits + DNA polymerase α catalytic subunit
    • 8d96 - hDNAP large subunit + DNA polymerase α catalytic subunit + DNA - Cryo EM
    • 8d0k 8d9d - hDNAP small + large subunits + CST + DNA polymerase α catalytic subunit + DNA – Cryo EM
    • 7u5c, 8d0b - hDNAP small + large subunits + CST + DNA polymerase α catalytic+B subunits + DNA – Cryo EM
    • 7opl - hDNAP small + large subunits + Nsp1 + DNA polymerase α catalytic+B subunits – Cryo EM
    • 7tl3, 7tl4 – yDNAP large subunit C terminal (mutant)
    • 8foc, 8fod, 8foe, 8foh, 8foj, 8fok - yDNAP small + large subunits + DNA polymerase α catalytic+B subunits – Cryo EM
    • 8g99 - fDNAP large subunit + DNA polymerase α catalytic+B subunits – frog - Cryo EM
    • 8ucv - fDNAP large subunit + DNA polymerase α catalytic subunit + DNA - Cryo EM
    • 8g9f - fDNAP small+large subunits + DNA polymerase α catalytic subunit + DNA - Cryo EM
    • 8g9o - fDNAP large subunit + DNA polymerase α catalytic+B subunits + DNA - Cryo EM
    • 8g9l - fDNAP large subunit + DNA polymerase α catalytic+B subunits + DNA + RNA - Cryo EM
  • Bacterial DNA primase
    • 1d0q - GsDNAP zinc-binding domain - Geobacillus stearothermophilus
    • 1z8s - GsdnaG dnaB binding domain - NMR
    • 2haj - EcdnaG catalytic domain - NMR
    • 1t3w – EcdnaG C-terminal
    • 1eqn, 1dd9, 1dde – EcdnaG catalytic core
    • 5w33 - MtudnaG RPD 112-432
    • 5z51 - MtudnaG helicase-binding domain 482-637
    • 5vaz – PadnaG
    • 4im9 – VcdnaG C-terminal
    • 3m1m – DNAP RNA polymerase domain – Sulfolobus islandicus
    • 1zt2, 2pa8, 2pmz, 3hkz, 5ofn - SsDNAP small + large subunit – Sulfolobus solfataricus
    • 2au3 – DNAP zinc-binding and RNAP domains – Aquifex aeolicus
    • 1v33 - PhDNAP small subunit – Pyrocuccus horikoshii
    • 1g71 - PfDNAP small subunit
    • 4e2k – SaDNAP – Staphylococcus aureus
    • 7ola, 7om0 – SaDNAP – Cryo EM
    • 2lzn – SaDNAP C terminal – NMR
    • 5guj – BsdnaG RNAP domain
    • 6gt7 – SiDNAP PRN1 helix bundle domain – Sulfolobus islandicus - NMR
    • 6gvu – SiDNAP PRN1 helix bundle domain + DNA - NMR
    • 6gvq, 6gvt – SiDNAP PRN1 helix bundle domain + DNA + ATP - NMR
  • Bacterial DNA primase complex
    • 2r6a, 2r6c - GsdnaG helicase binding domain + helicase
    • 4m4w - GsdnaG helicase binding domain + helicase + DnaI
    • 3b39 – EcdnaG catalytic domain + DNA
    • 7t22, 7t23 – EcdnaG C-terminal (mutant) + helicase + DNA – Cryo EM
    • 5w36, 5w35, 5w34 - MtudnaG + DNA
    • 1v34 - PhDNAP small subunit + UTP
    • 4edg, 4edk, 4edr, 4edt, 4edv, 4ee1 – SaDNAP + nucleotide
    • 5of3 - SsDNAP small + large subunit + protein
    • 7uy8 - DNAP small + large subunits + DNA polymerase α catalytic+B subunits – Tetrahymena thermophile - Cryo EM


  • Phage DNA primase
    • 6a9w, 6k9b - NrsDNAP N terminal 1-305 – Nitratiruptor phage Nrs
    • 6k9c, 6k9e, 6lrb - NrsDNAP C terminal 305-718
    • 6jon, 6jop, 6joq, 6k9a - NrsDNAP N terminal + nucleotide
    • 8dwj – T4DNAP + RNA + DNA – Escherichia phage T4 – Cryo EM
    • 8dvf, 8dvi, 8dw6 – T4DNAP + helicase + DNA – Cryo EM
    • 8gao – T4DNAP + helicase + DNA + RNA – Cryo EM
  • RNA polymerase from Bacteriophage T7 or DNA primase/helicase or GP4
  • RNA-dependent RNAP or cap-snatching endonuclease
    • 7roz – AtRNAP 2 – Cryo EM
    • 3phu, 1khv, 1khw – HfRNAP L RNA-directed – Hemorrhagic fever virus
    • 5v5i, 5v5h, 5v5g – HfRNAP L + ubiquitin
    • 2xwh, 2xxd, 2xhu, 2xhw, 3i5k, 1c2p, 1csj, 1quv, 1yuy, 1yv2, 1yvx, 1yvz, 3gsz, 4aep, 4aex, 2wrm, 3mwv, 3mww – HvRNAP Ns5b domain – Hepatitis virus
    • 3vc8 - HvRNAP cytoplasmic domain C terminal
    • 3vcb, 4ry4, 4ry5, 4ry6, 4ry7 - HvRNAP cytoplasmic domain C terminal (mutant)
    • 2xym, 2xhv, 2xi2, 4e76, 4adp, 4obc, 4wt9 - HvRNAP Ns5b domain (mutant)
    • 1rdr - PoRNAP – Polio virus
    • 1tql, 2ijd, 2ijf, 4nlo, 4nlp, 4nlq, 4nlr, 4nls, 4nlt, 4nlu, 4nlv, 4nlw, 4nlx, 4nly, 4r0e - PoRNAP (mutant)
    • 2xi5, 2xi7 – BvRNAP L N-terminal – Bunyavirus
    • 7x6s – LcvRNAP L– Lymphocytic choriomengitis virus - Cryo EM
    • 3jsb – LcvRNAP L (mutant)
    • 2wk4, 2uut, 2uuw – SvRNAP (mutant) – Sapporo virus
    • 2ckw - SvRNAP residues 1135-1649
    • 3nky, 4wyl, 4wyw, 6gvv - FmRNAP (mutant) - Foot-and-mouth virus
    • 1hhs, 4a8o, 4b02, 1hi8, 5fj6 – P6RNAP – Bacteriophage φ-6
    • 7ogp, 7ogr – RNAP – Bacteriophage φ-kz – Cryo EM
    • 7s00, 7um1 – AR9RNAP – Bacteriophage AR9 – Cryo EM
    • 7s01, 7um0 – AR9RNAP + DNA – Cryo EM
    • 2jl9, 2jlf, 1wac – P6RNAP (mutant)
    • 5fj7 – P6RNAP + major inner protein P1
    • 2po4 – N4RNAP polymerase domain – Bacteriophage N4
    • 1l9k – DevRNAP N terminal – Dengue virus
    • 2j7u, 4c11 - DevRNAP polymerase domain
    • 5ccv - DevRNAP NS5
    • 1oks – RNAP α subunit – Measles virus
    • 1r4g - RNAP α subunit – Sendai virus – NMR
    • 1s48, 1s49, 1s4f – DvRNAP residues 71-679 – Diarrhea virus
    • 2cjq - DvRNAP polymerase domain
    • 1sh0, 1sh2, 1sh3 - NvRNAP C terminal – Norwalk virus
    • 1vyi - RNAP α subunit C terminal – Rabies virus
    • 2hcn, 2hcs, 2hfz – RNAP polymerase domain – West Nile virus
    • 2pgg, 2pus – RNAP – Bursal disease virus
    • 2r7o, 2r7q – SrRNAP – Simian rotavirus
    • 4au6 - RNAP – bovine rotavirus – Cryo-EM
    • 2yi8, 2yi9, 2yia, 2yib – IpnvRNAP – Infectious pancreatic necrosis virus
    • 3n6l – EvRNAP – Human enterovirus
    • 4uci, 4ucj, 4ucl, 4ucy, 4ucz – HmpvRNAP L residues 1600-2005 – Human metapneumovirus
    • 4uck, 4ud0 – HmpvRNAP L residues 1600-2005 (mutant)
    • 4zp8, 4zp9, 4zpa, 4zpb, 4zpc, 4zpd – CvRNAP residues 1724-2185 (mutant) – Coxsackievirus
    • 3ddk – CvRNAP residues 1724-2185
    • 3nah, 3nai, 3qid, 3uqs – MnvRNAP – Murine norovirus
    • 4wfx, 4wfy, 4wfz – CvRNAP RdrP domain (mutant)
    • 2j7n, 2j7o – NcRNAP residues 381-1402 – Neurospora crassa
    • 4gzk, 4ieg – RNAP – cystovirus 12
    • 4i1t – RNAP L – Pichinde virus
    • 5chs – VsivRNAP L N-terminal – Vescicular stomatitis Indiana virus
    • 4xha, 4xhi, 7om2, 7om9 – TavRNAP RdRP – Thosea asigna virus
    • 6l42 – RNAP L – Phlebovirus – Cryo EM
    • 6l4r – RNAP – Enterovirus
    • 6ntv – SftvRNAP – Severe fever with thrombocytopenia virus – Cryo EM
    • 6ntv – SftvRNAP endonuclease domain 1-226
    • 6lkx – RNAP – Porcine respiratory virus
    • 6kld, 7vh2, 7vh3 – MavRNAP L – Machupo virus – Cryo EM
    • 6klc, 7och, 7oe3, 7oe7 – LvRNAP L – Lassa virus – Cryo EM
    • 4miw, 5izh, 5j1n, 5j1p – LvRNAP L N terminal
    • 4mtp, 7d6n – EnvRNAP RdrP module – Encephalitis virus
    • 4cgx, 4chc – TvRNAP N terminal – Thogoto virus
    • 4chd – TvRNAP 627 domain
    • 4che, 4chf – TvRNAP cap-binding domain
    • 5fsw - NvRNAP C terminal – Thielavia terrestris
    • 5hsb – RNAP – Andes virus
    • 5ize – HavRNAP L – Hantaan virus
    • 8c4s – HavRNAP L – Cryo EM
    • 5ltf – LcmvRNAP L – Lymphocytic choriomeningitis mammarenavirus
    • 5lts - LcmvRNAP (mutant)
    • 5u0c, 6ld1 - ZvRNAP NS5 polymerase domain 2781-3419 – Zika virus
    • 6qw5, 6qw0, 6qvv - RNAP – Toscana virus
    • 6dx5 - RNAP OTU domain – Farallon virus
    • 6dx3 - RNAP OTU domain – Taggert virus
    • 6dx2 - RNAP OTU domain – Dera Ghazi khan virus
    • 6dx1, 6dwx - RNAP OTU domain – Qulybus virus
    • 7eei – RNAP (mutant) – Rift valley fever virus – Cryo EM
  • RNA-dependent RNAP complex with RNA
  • RNA-dependent RNAP complex with protein
    • 3phw, 2pt2, 3pt2 – HfRNAP + ubiquitin
    • 3phx, 3pse – HfRNAP + ISG15
    • 6u5o – HmpvRNAP L + phosphoprotein – Cryo EM
    • 8fpj – HmpvRNAP L + MRK-1 – Cryo EM
    • 6pzk, 6uen, 8fpi, 8fu3 – RNAP L + phosphoprotein – Human respiratory syncytial virus - Cryo EM
    • 6v85, 6v86 – RNAP L + phosphoprotein – Parainfluenza virus
    • 6po2, 6pns – RNAP + VP3 – Bluetongue virus - Cryo EM
    • 2d7s, 2f8e, 8c1n – FmRNAP + VPG
    • 8c2p – FmRNAP + protein 3B-3
    • 5y3d – MnvRNAP + VPG
    • 3cdw - CvRNAP + POP + VPG
    • 4f5x – SrRNAP + Vp2 + Vp6
    • 3zed – IpnvRNAP + capsid protein Vp3
    • 6u1x – VsivRNAP + phosphoprotein
    • 4hxd – RNAP L + polyubiquitin-C – Dugbe virus
    • 4r71 – RNAP b chain + EF-TS EF-TU + RPS1 – Enterobacteria phage qbeta
    • 5jze – RNAP + ISG15 – Erve virus
    • 6tz0, 6ty8 – BmcpvRNAP + Vp4 – Bombyx mori cytoplasmic polyhedrosis virus – Cryo EM
    • 6tz2, 6tz1, 6ty9, 5h0r – BmcpvRNAP + Vp4 – RNA – Cryo EM
    • 6ogy – RvARNAP + Vp2 + RNA – Cryo EM
    • 6k32 – RvARNAP + Vp1 + Vp4 + RNA – Cypovirus 1 - Cryo EM
    • 6oar, 6oat – RNAP OUT domain + ISG17 – Kupe virus
    • 7yer, 7yes, 8jsl, 8jsm, 8jsn – EbvRNAP + Vp35 – Ebola virus – Cryo EM
    • 7yet – EbvRNAP + Vp35+ drug – Cryo EM
    • 7ckl, 7ckm, 7elb, 7vgq, 7vh1 – MavRNAP L + matrix protein Z – Cryo EM
    • 7el9, 7elc – MavRNAP L + matrix protein Z + RNA – Cryo EM
    • 7x6v – LcvRNAP L + matrix protein Z – Cryo EM
    • 7eju – RNAP L + matrix protein Z – Junin virus - Cryo EM
    • 7yot, 7yov, 7you – RNAP + P protein – Newcastle disease virus – Cryo EM
  • RNA-dependent RNAP from SARS-COV2”
    • 7btf, 7bw4 – SCRNAP + non-structural proteins – SARS-COV-2 - Cryo EM
    • 6xqb, 7bzf, 7c2k, 7uo7, 7uo9, 7uob, 7uoe, 8gwb, 8gwe – SCRNAP + non-structural proteins + RNA - Cryo EM
    • 7aap, 7b38, 7b3c, 7ctt, 7d4f, 7dfg, 7dfh, 7doi, 7dok, 7l1f, 7p35, 7uo4 – SCRNAP + non-structural proteins + RNA + drug - Cryo EM
    • 7ed5, 8gwn, 8gwo – SCRNAP + non-structural proteins + RNA + inhibitor - Cryo EM
    • 7krn, 7rdx, 7rdy, 7rdz, 7re0, 7re1, 7re2, 7re3 – SCRNAP + non-structural proteins + RNA + helicase - Cryo EM
    • 7cxm, 7cxn, 7cyq – SCRNAP 4393-5324 (mutant)+ non-structural proteins + RNA + helicase - Cryo EM
    • 7oyg – SCRNAP + non-structural proteins + RNA + PP1AB - Cryo EM
    • 8gy6 – SCRNAP + non-structural proteins + RNA + toxin - Cryo EM
    • 8gwf, 8gwg – SCRNAP + non-structural proteins + RNA + helicase + inhibitor - Cryo EM
    • 7eiz – SCRNAP + non-structural proteins + RNA + methyltransferase + exoribonuclease - Cryo EM
  • RNA-dependent RNAP complex with small molecule
  • Influenza virus polymerase acidic protein (or PA or subunit P2) N terminal 1-256; C-terminal 257-716


  • Influenza virus polymerase basic protein 2 (or RNAP subunit P3 or PB2)); Domains: cap-binding 318-483; Cap-binding and midlink 247-536; 627 538-693; NLS 694-753
    • 4enf, 4u6o, 4j2r, 2vqz, 5ef9, 5eg9 – IvRNAP PB2 cap-binding domain
    • 3wi0 – IvRNAP PB2 cap-binding domain (mutant)
    • 7as2, 7as3 – IvRNAP PB2 cap-binding domain (mutant) + VX
    • 7nft – IvRNAP PB2 cap-binding domain + nanobody
    • 3cw4 - IvRNAP PB2 627 + NLS domains
    • 2gmo - IvRNAP PB2 627 + NLS domains - NMR
    • 4eqk, 5efa, 5efc – IvRNAP PB2 cap-binding domain + GTP
    • 4nce, 3wi1 – IvRNAP PB2 cap-binding domain (mutant) + GTP derivative
    • 4p1u, 4yd0, 5buh, 5jun, 5jur, 7as0, 7xme - IvRNAP PB2 cap-binding domain + inhibitor
    • 4ncm, 7as1 – IvRNAP PB2 cap-binding domain (mutant) + inhibitor
    • 6euy, 6eux, 6euv - IvRNAP PB2 cap-binding + midlink domains + inhibitor
    • 5wl0 - IvRNAP PB2 cap-binding + midlink + 627 + NLS domains + inhibitor
    • 4uad, 4uae, 4uaf - IvRNAP PB2 + importin
    • 2vy6 - IvRNAP PB2 627 + NLS domains
    • 2vy7 - IvRNAP PB2 627 domain
    • 2vy8 - IvRNAP PB2 627 domain (mutant)
  • Influenza virus RNAP PA+PB1
    • 2znl - IvRNAP PA + PB1
    • 3cm8 - IvRNAP PA residues 256-716 + PB1 peptide
  • Influenza virus RNAP PA+PB2
  • Influenza virus RNAP PB1+PB2
    • 2ztt, 3a1g - IvRNAP PB1 C terminal + RNAP PB2 N terminal
    • 3j9b - IvRNAP PB1+PB2 N terminal + RNA
  • Influenza virus RNAP PB1+P2+P3
  • Influenza virus RNAP PA+PB1+PB2 (subunits P1+p2+p3)

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Michal Harel, Joel L. Sussman, Jaime Prilusky

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